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• W2942696920 abstract "Material properties of implants such as volume porosity and nanoscale surface modification have been shown to enhance cell-material interactions in vitro and osseointegration in vivo. Porous tantalum (Ta) and titanium (Ti) coatings are widely used for non-cemented implants, which are fabricated using different processing routes. In recent years, some of those implants are being manufactured using additive manufacturing. However, limited knowledge is available on direct comparison of additively manufactured porous Ta and Ti structures towards early stage osseointegration. In this study, we have fabricated porous Ta and Ti6Al4V (Ti64) implants using laser engineered net shaping (LENS™) with similar volume fraction porosity to compare the influence of surface characteristics and material chemistry on in vivo response using a rat distal femur model for 5 and 12 weeks. We have also assessed whether surface modification on Ti64 can elicit similar in vivo response as porous Ta in a rat distal femur model for 5 and 12 weeks. The harvested implants were histologically analyzed for osteoid surface per bone surface. Field emission scanning electron microscopy (FESEM) was done to assess the bone-implant interface. The results presented here indicate comparable performance of porous Ta and surface modified porous Ti64 implants towards early stage osseointegration at 5 weeks post implantation through seamless bone-material interlocking. However, a continued and extended efficacy of porous Ta is found in terms of higher osteoid formation at 12 weeks post-surgery." @default.
• W2942696920 created "2019-05-09" @default.
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• W2942696920 date "2019-08-01" @default.
• W2942696920 modified "2023-10-14" @default.
• W2942696920 title "Direct comparison of additively manufactured porous titanium and tantalum implants towards in vivo osseointegration" @default.
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• W2942696920 doi "https://doi.org/10.1016/j.addma.2019.04.025" @default.
• W2942696920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6690615" @default.
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• W2942696920 hasPublicationYear "2019" @default.
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