Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942743247> ?p ?o ?g. }
- W2942743247 endingPage "297" @default.
- W2942743247 startingPage "290" @default.
- W2942743247 abstract "Perfluoroalkyl phosphinic acids (PFPiAs, including 6:6, 6:8 and 8:8 PFPiAs) are one kind of emerging perfluoroalkyl substances and usually used as leveling and wetting agents in household cleaning products and pesticide formulations. In this study, zebrafish embryos (6 h post-fertilization [hpf]) were exposed to 6:6, 6:8 and 8:8 PFPiAs individually (0.5, 5 and 50 nM) for 168 hpf. 8:8 PFPiA at 5 and 50 nM reduced the body length, while all treatments of 6:8 and 8:8 PFPiA depressed the heartbeat of the zebrafish larvae. 8:8 PFPiA at 50 nM distinctly enhanced the thyroxine (T4) and triiodothyronine (T3) contents. In a negative feedback mechanism, the three PFPiAs remarkably suppressed the genes responsible for THs regulation (corticotropin-releasing hormone, crh; thyroid stimulating hormone, tshβ), and 8:8 PFPiA displayed the strongest effect. In addition, 8:8 PFPiA significantly promoted the gene expressions corresponding to THs transport, metabolism and action (transthyretin, ttr; uridine diphosphate glucuronosyltransferase, ugt1ab; deiodinases, dio1 and dio2; thyroid hormone receptors, trα and trβ). As a result, 8:8 PFPiA displayed the strongest thyroid endocrine disrupting effect and significantly affected the growth of zebrafish larvae among the three PFPiAs in the present study." @default.
- W2942743247 created "2019-05-09" @default.
- W2942743247 creator A5000093173 @default.
- W2942743247 creator A5024845093 @default.
- W2942743247 creator A5038110820 @default.
- W2942743247 creator A5044294158 @default.
- W2942743247 creator A5051990971 @default.
- W2942743247 creator A5058696568 @default.
- W2942743247 creator A5074112736 @default.
- W2942743247 creator A5084587333 @default.
- W2942743247 date "2019-08-01" @default.
- W2942743247 modified "2023-10-12" @default.
- W2942743247 title "Thyroid endocrine disruption effects of perfluoroalkyl phosphinic acids on zebrafish at early development" @default.
- W2942743247 cites W1964923030 @default.
- W2942743247 cites W1968619649 @default.
- W2942743247 cites W1972238619 @default.
- W2942743247 cites W1974590149 @default.
- W2942743247 cites W1976228062 @default.
- W2942743247 cites W1980335896 @default.
- W2942743247 cites W1981348969 @default.
- W2942743247 cites W1992638724 @default.
- W2942743247 cites W1996481088 @default.
- W2942743247 cites W1999011937 @default.
- W2942743247 cites W2000275279 @default.
- W2942743247 cites W2004758406 @default.
- W2942743247 cites W2004981949 @default.
- W2942743247 cites W2018354811 @default.
- W2942743247 cites W2019294191 @default.
- W2942743247 cites W2025783042 @default.
- W2942743247 cites W2030254991 @default.
- W2942743247 cites W2033805763 @default.
- W2942743247 cites W2038275117 @default.
- W2942743247 cites W2039796662 @default.
- W2942743247 cites W2040001432 @default.
- W2942743247 cites W2040004615 @default.
- W2942743247 cites W2040558296 @default.
- W2942743247 cites W2051786885 @default.
- W2942743247 cites W2061197282 @default.
- W2942743247 cites W2070225924 @default.
- W2942743247 cites W2072012875 @default.
- W2942743247 cites W2075442155 @default.
- W2942743247 cites W2077095632 @default.
- W2942743247 cites W2084324312 @default.
- W2942743247 cites W2091738415 @default.
- W2942743247 cites W2103692242 @default.
- W2942743247 cites W2110541778 @default.
- W2942743247 cites W2125349610 @default.
- W2942743247 cites W2131360426 @default.
- W2942743247 cites W2138071206 @default.
- W2942743247 cites W2142908518 @default.
- W2942743247 cites W2148333750 @default.
- W2942743247 cites W2156416721 @default.
- W2942743247 cites W2165732918 @default.
- W2942743247 cites W2168464188 @default.
- W2942743247 cites W2172114836 @default.
- W2942743247 cites W2192088777 @default.
- W2942743247 cites W2278858564 @default.
- W2942743247 cites W2293481204 @default.
- W2942743247 cites W2317886628 @default.
- W2942743247 cites W2323641343 @default.
- W2942743247 cites W2331867357 @default.
- W2942743247 cites W2334111775 @default.
- W2942743247 cites W2409263109 @default.
- W2942743247 cites W2481577760 @default.
- W2942743247 cites W2506745242 @default.
- W2942743247 cites W2516355060 @default.
- W2942743247 cites W2520535978 @default.
- W2942743247 cites W2591018684 @default.
- W2942743247 cites W2739513638 @default.
- W2942743247 cites W2766824218 @default.
- W2942743247 cites W2772722868 @default.
- W2942743247 cites W2790263654 @default.
- W2942743247 cites W2793283003 @default.
- W2942743247 cites W2793401494 @default.
- W2942743247 cites W2794227565 @default.
- W2942743247 cites W2795734533 @default.
- W2942743247 cites W2801487844 @default.
- W2942743247 cites W2805671689 @default.
- W2942743247 cites W2810178673 @default.
- W2942743247 cites W2884242630 @default.
- W2942743247 cites W2886258826 @default.
- W2942743247 cites W2898633268 @default.
- W2942743247 doi "https://doi.org/10.1016/j.scitotenv.2019.04.177" @default.
- W2942743247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31048160" @default.
- W2942743247 hasPublicationYear "2019" @default.
- W2942743247 type Work @default.
- W2942743247 sameAs 2942743247 @default.
- W2942743247 citedByCount "33" @default.
- W2942743247 countsByYear W29427432472019 @default.
- W2942743247 countsByYear W29427432472020 @default.
- W2942743247 countsByYear W29427432472021 @default.
- W2942743247 countsByYear W29427432472022 @default.
- W2942743247 countsByYear W29427432472023 @default.
- W2942743247 crossrefType "journal-article" @default.
- W2942743247 hasAuthorship W2942743247A5000093173 @default.
- W2942743247 hasAuthorship W2942743247A5024845093 @default.
- W2942743247 hasAuthorship W2942743247A5038110820 @default.
- W2942743247 hasAuthorship W2942743247A5044294158 @default.