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• W2942743302 abstract "Life builds its molecules from carbon dioxide (CO2) and breaks them back down again through the intermediacy of just five metabolites, which are the universal hubs of biochemistry1. However, it is unclear how core biological metabolism began and why it uses the intermediates, reactions and pathways that it does. Here we describe a purely chemical reaction network promoted by ferrous iron, in which aqueous pyruvate and glyoxylate-two products of abiotic CO2 reduction2-4-build up 9 of the 11 intermediates of the biological Krebs (or tricarboxylic acid) cycle, including all 5 universal metabolic precursors. The intermediates simultaneously break down to CO2 in a life-like regime that resembles biological anabolism and catabolism5. Adding hydroxylamine6-8 and metallic iron into the system produces four biological amino acids in a manner that parallels biosynthesis. The observed network overlaps substantially with the Krebs and glyoxylate cycles9,10, and may represent a prebiotic precursor to these core metabolic pathways." @default.
• W2942743302 created "2019-05-09" @default.
• W2942743302 creator A5012716637 @default.
• W2942743302 creator A5069940766 @default.
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• W2942743302 date "2019-05-01" @default.
• W2942743302 modified "2023-10-17" @default.
• W2942743302 title "Synthesis and breakdown of universal metabolic precursors promoted by iron" @default.
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• W2942743302 doi "https://doi.org/10.1038/s41586-019-1151-1" @default.
• W2942743302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6517266" @default.
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