FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942783251> ?p ?o ?g. }

• W2942783251 endingPage "203" @default.
• W2942783251 startingPage "193" @default.
• W2942783251 abstract "BackgroundCat allergy in human subjects is usually caused by the major cat allergen Fel d 1 and is found in approximately 10% of the Western population. Currently, there is no efficient and safe therapy for cat allergy available. Allergic patients usually try to avoid cats or treat their allergy symptoms.ObjectiveWe developed a new strategy to treat Fel d 1–induced allergy in human subjects by immunizing cats against their own major allergen, Fel d 1.MethodsA conjugate vaccine consisting of recombinant Fel d 1 and a virus-like particle derived from the cucumber mosaic virus containing the tetanus toxin–derived universal T-cell epitope tt830-843 (CuMVTT) was used to immunize cats. A first tolerability and immunogenicity study, including a boost injection, was conducted by using the Fel-CuMVTT vaccine alone or in combination with an adjuvant.ResultsThe vaccine was well tolerated and had no overt toxic effect. All cats induced a strong and sustained specific IgG antibody response. The induced anti–Fel d 1 antibodies were of high affinity and exhibited a strong neutralization ability tested both in vitro and in vivo. A reduction in the endogenous allergen level and a reduced allergenicity of tear samples, were observed.ConclusionVaccination of cats with Fel-CuMVTT induces neutralizing antibodies and might result in reduced symptoms of allergic cat owners. Both human subjects and animals could profit from this treatment because allergic cat owners would reduce their risk of developing chronic diseases, such as asthma, and become more tolerant of their cats, which therefore could stay in the households and not need to be relinquished to animal shelters. Cat allergy in human subjects is usually caused by the major cat allergen Fel d 1 and is found in approximately 10% of the Western population. Currently, there is no efficient and safe therapy for cat allergy available. Allergic patients usually try to avoid cats or treat their allergy symptoms. We developed a new strategy to treat Fel d 1–induced allergy in human subjects by immunizing cats against their own major allergen, Fel d 1. A conjugate vaccine consisting of recombinant Fel d 1 and a virus-like particle derived from the cucumber mosaic virus containing the tetanus toxin–derived universal T-cell epitope tt830-843 (CuMVTT) was used to immunize cats. A first tolerability and immunogenicity study, including a boost injection, was conducted by using the Fel-CuMVTT vaccine alone or in combination with an adjuvant. The vaccine was well tolerated and had no overt toxic effect. All cats induced a strong and sustained specific IgG antibody response. The induced anti–Fel d 1 antibodies were of high affinity and exhibited a strong neutralization ability tested both in vitro and in vivo. A reduction in the endogenous allergen level and a reduced allergenicity of tear samples, were observed. Vaccination of cats with Fel-CuMVTT induces neutralizing antibodies and might result in reduced symptoms of allergic cat owners. Both human subjects and animals could profit from this treatment because allergic cat owners would reduce their risk of developing chronic diseases, such as asthma, and become more tolerant of their cats, which therefore could stay in the households and not need to be relinquished to animal shelters." @default.
• W2942783251 created "2019-05-09" @default.
• W2942783251 creator A5006373917 @default.
• W2942783251 creator A5006632216 @default.
• W2942783251 creator A5012160425 @default.
• W2942783251 creator A5015374294 @default.
• W2942783251 creator A5017874343 @default.
• W2942783251 creator A5018979672 @default.
• W2942783251 creator A5023175435 @default.
• W2942783251 creator A5024045394 @default.
• W2942783251 creator A5030120350 @default.
• W2942783251 creator A5070385423 @default.
• W2942783251 creator A5073011326 @default.
• W2942783251 creator A5084884183 @default.
• W2942783251 creator A5088874006 @default.
• W2942783251 creator A5090561267 @default.
• W2942783251 date "2019-07-01" @default.
• W2942783251 modified "2023-10-10" @default.
• W2942783251 title "Immunization of cats to induce neutralizing antibodies against Fel d 1, the major feline allergen in human subjects" @default.
• W2942783251 cites W1515043996 @default.
• W2942783251 cites W1582393017 @default.
• W2942783251 cites W1971050141 @default.
• W2942783251 cites W1972950391 @default.
• W2942783251 cites W1973776718 @default.
• W2942783251 cites W1978147729 @default.
• W2942783251 cites W1982130154 @default.
• W2942783251 cites W1991701295 @default.
• W2942783251 cites W2000981638 @default.
• W2942783251 cites W2001268467 @default.
• W2942783251 cites W2005219111 @default.
• W2942783251 cites W2007622060 @default.
• W2942783251 cites W2009021252 @default.
• W2942783251 cites W2016738915 @default.
• W2942783251 cites W2016995998 @default.
• W2942783251 cites W2021994684 @default.
• W2942783251 cites W2028065290 @default.
• W2942783251 cites W2048179593 @default.
• W2942783251 cites W2052063445 @default.
• W2942783251 cites W2054949003 @default.
• W2942783251 cites W2056036907 @default.
• W2942783251 cites W2057868114 @default.
• W2942783251 cites W2070938434 @default.
• W2942783251 cites W2074097233 @default.
• W2942783251 cites W2080229642 @default.
• W2942783251 cites W2085879141 @default.
• W2942783251 cites W2088033193 @default.
• W2942783251 cites W2095190947 @default.
• W2942783251 cites W2099241512 @default.
• W2942783251 cites W2138366728 @default.
• W2942783251 cites W2138989637 @default.
• W2942783251 cites W2147698768 @default.
• W2942783251 cites W2151497845 @default.
• W2942783251 cites W2515370071 @default.
• W2942783251 cites W2590348424 @default.
• W2942783251 cites W2744398585 @default.
• W2942783251 cites W2763661741 @default.
• W2942783251 cites W2787516621 @default.
• W2942783251 cites W2795898959 @default.
• W2942783251 cites W2796040922 @default.
• W2942783251 cites W2911619521 @default.
• W2942783251 cites W4244541582 @default.
• W2942783251 cites W4254466578 @default.
• W2942783251 doi "https://doi.org/10.1016/j.jaci.2019.01.050" @default.
• W2942783251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31056187" @default.
• W2942783251 hasPublicationYear "2019" @default.
• W2942783251 type Work @default.
• W2942783251 sameAs 2942783251 @default.
• W2942783251 citedByCount "40" @default.
• W2942783251 countsByYear W29427832512019 @default.
• W2942783251 countsByYear W29427832512020 @default.
• W2942783251 countsByYear W29427832512021 @default.
• W2942783251 countsByYear W29427832512022 @default.
• W2942783251 countsByYear W29427832512023 @default.
• W2942783251 crossrefType "journal-article" @default.
• W2942783251 hasAuthorship W2942783251A5006373917 @default.
• W2942783251 hasAuthorship W2942783251A5006632216 @default.
• W2942783251 hasAuthorship W2942783251A5012160425 @default.
• W2942783251 hasAuthorship W2942783251A5015374294 @default.
• W2942783251 hasAuthorship W2942783251A5017874343 @default.
• W2942783251 hasAuthorship W2942783251A5018979672 @default.
• W2942783251 hasAuthorship W2942783251A5023175435 @default.
• W2942783251 hasAuthorship W2942783251A5024045394 @default.
• W2942783251 hasAuthorship W2942783251A5030120350 @default.
• W2942783251 hasAuthorship W2942783251A5070385423 @default.
• W2942783251 hasAuthorship W2942783251A5073011326 @default.
• W2942783251 hasAuthorship W2942783251A5084884183 @default.
• W2942783251 hasAuthorship W2942783251A5088874006 @default.
• W2942783251 hasAuthorship W2942783251A5090561267 @default.
• W2942783251 hasBestOaLocation W29427832511 @default.
• W2942783251 hasConcept C126322002 @default.
• W2942783251 hasConcept C159047783 @default.
• W2942783251 hasConcept C159654299 @default.
• W2942783251 hasConcept C195616568 @default.
• W2942783251 hasConcept C197934379 @default.
• W2942783251 hasConcept C203014093 @default.
• W2942783251 hasConcept C207480886 @default.
• W2942783251 hasConcept C2777863537 @default.
• W2942783251 hasConcept C2778375690 @default.

• next