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- W2942809265 abstract "This study aimed to evaluate the bactericidal efficacy of leaves obtained from an Australian native plant (denoted as 8479) against 19 bacteria. The antibacterial activity of 8479 was determined using the well diffusion assay, whilst broth microdilution assay was used to measure the minimum inhibitory concentration (MIC). Several chromatographic (i.e., normal phase flash column, reversed phase high performance liquid chromatography) and spectroscopic (i.e. nuclear magnetic resonance, mass spectroscopy) techniques were used to isolate and identify bioactive compounds derived from the plant. The crude methanolic extract at a concentration of 100 mg/mL was bactericidal against numerous Gram-positive bacteria (B. cereus, MSSA, MRSA isolates, S. pyogenes, B. subtilis and S. epidermidis) and vancomycin-resistant enterococci E. gallinarum, E casseliflavus, E. faecalis and E. faecium. To date, phenolic compounds have been purified from the methanolic extract of 8479. The MICs of the compounds ranged between 8-64 µg/mL. Further, current results demonstrate that crude methanolic extracts, as well as purified compounds have antibacterial activity against several common-wound colonising bacteria." @default.
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- W2942809265 date "2018-01-01" @default.
- W2942809265 modified "2023-09-26" @default.
- W2942809265 title "Phytochemical screening and antibacterial studies of an Australian native plant" @default.
- W2942809265 hasPublicationYear "2018" @default.
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