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- W2942850956 abstract "Nitric oxide (NO) is produced by enzymatic activity of neuronal (nNOS), endothelial (eNOS), and inducible nitric oxide synthase (iNOS) and modulates a broad spectrum of physiological and pathophysiological conditions. The iNOS isoform is positively regulated at transcriptional level and produces high levels of NO in response to inflammatory mediators and/or to pattern recognition receptor signaling, such as Toll-like receptors. In this review, we compiled the main contributions of our group for understanding of the role of NO in sepsis and arthritis outcome and the peripheral contributions of NO to inflammatory pain development. Although neutrophil iNOS-derived NO is necessary for bacterial killing, systemic production of high levels of NO impairs neutrophil migration to infections through inhibiting neutrophil adhesion on microcirculation and their locomotion. Moreover, neutrophil-derived NO contributes to multiple organ dysfunction in sepsis. In arthritis, NO is chief for bacterial clearance in staphylococcal-induced arthritis; however, it contributes to articular damage and bone mass degradation. NO produced in inflammatory sites also downmodulates pain. The mechanism involved in analgesic effect and inhibition of neutrophil migration is dependent on the activation of the classical sGC/cGMP/PKG pathway. Despite the increasing number of studies performed after the identification of NO as an endothelium-derived relaxing factor, the underlying mechanisms of NO in inflammatory diseases remain unclear." @default.
- W2942850956 created "2019-05-09" @default.
- W2942850956 creator A5006994441 @default.
- W2942850956 creator A5017615120 @default.
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- W2942850956 creator A5031690868 @default.
- W2942850956 creator A5045881290 @default.
- W2942850956 creator A5050221969 @default.
- W2942850956 date "2019-08-01" @default.
- W2942850956 modified "2023-10-14" @default.
- W2942850956 title "Targeting nitric oxide as a key modulator of sepsis, arthritis and pain" @default.
- W2942850956 cites W1526943601 @default.
- W2942850956 cites W1543202257 @default.
- W2942850956 cites W1577193514 @default.
- W2942850956 cites W1581327518 @default.
- W2942850956 cites W1584738578 @default.
- W2942850956 cites W1599668696 @default.
- W2942850956 cites W1611522350 @default.
- W2942850956 cites W1614380970 @default.
- W2942850956 cites W1757150729 @default.
- W2942850956 cites W1866890560 @default.
- W2942850956 cites W1927476402 @default.
- W2942850956 cites W1963483865 @default.
- W2942850956 cites W1963760749 @default.
- W2942850956 cites W1965483709 @default.
- W2942850956 cites W1966176207 @default.
- W2942850956 cites W1969795252 @default.
- W2942850956 cites W1971900596 @default.
- W2942850956 cites W1972672472 @default.
- W2942850956 cites W1972716495 @default.
- W2942850956 cites W1973232510 @default.
- W2942850956 cites W1979947873 @default.
- W2942850956 cites W1980123081 @default.
- W2942850956 cites W1983863797 @default.
- W2942850956 cites W1985260340 @default.
- W2942850956 cites W1986740857 @default.
- W2942850956 cites W1991142272 @default.
- W2942850956 cites W1991484350 @default.
- W2942850956 cites W1994602325 @default.
- W2942850956 cites W1994805173 @default.
- W2942850956 cites W1998172352 @default.
- W2942850956 cites W2000983477 @default.
- W2942850956 cites W2004413322 @default.
- W2942850956 cites W2007366640 @default.
- W2942850956 cites W2010630254 @default.
- W2942850956 cites W2014185451 @default.
- W2942850956 cites W2020212514 @default.
- W2942850956 cites W2022745533 @default.
- W2942850956 cites W2022848089 @default.
- W2942850956 cites W2024707001 @default.
- W2942850956 cites W2026452714 @default.
- W2942850956 cites W2026927834 @default.
- W2942850956 cites W2027626913 @default.
- W2942850956 cites W2030160635 @default.
- W2942850956 cites W2031582116 @default.
- W2942850956 cites W2039396863 @default.
- W2942850956 cites W2040393757 @default.
- W2942850956 cites W2041831078 @default.
- W2942850956 cites W2042117411 @default.
- W2942850956 cites W2043462193 @default.
- W2942850956 cites W2044924856 @default.
- W2942850956 cites W2048187420 @default.
- W2942850956 cites W2051061580 @default.
- W2942850956 cites W2052265237 @default.
- W2942850956 cites W2060289279 @default.
- W2942850956 cites W2061181212 @default.
- W2942850956 cites W2064524909 @default.
- W2942850956 cites W2065345742 @default.
- W2942850956 cites W2066847273 @default.
- W2942850956 cites W2067052573 @default.
- W2942850956 cites W2068575727 @default.
- W2942850956 cites W2068669639 @default.
- W2942850956 cites W2071106984 @default.
- W2942850956 cites W2071232958 @default.
- W2942850956 cites W2071823872 @default.
- W2942850956 cites W2072116932 @default.
- W2942850956 cites W2075715972 @default.
- W2942850956 cites W2077441327 @default.
- W2942850956 cites W2078028469 @default.
- W2942850956 cites W2086305651 @default.
- W2942850956 cites W2086871241 @default.
- W2942850956 cites W2091599164 @default.
- W2942850956 cites W2092595668 @default.
- W2942850956 cites W2093748429 @default.
- W2942850956 cites W2094763284 @default.
- W2942850956 cites W2095249660 @default.
- W2942850956 cites W2095952820 @default.
- W2942850956 cites W2101392591 @default.
- W2942850956 cites W2106299459 @default.
- W2942850956 cites W2112725433 @default.
- W2942850956 cites W2113255929 @default.
- W2942850956 cites W2114298357 @default.
- W2942850956 cites W2115158780 @default.
- W2942850956 cites W2115421980 @default.
- W2942850956 cites W2121391159 @default.
- W2942850956 cites W2122386753 @default.
- W2942850956 cites W2122515902 @default.
- W2942850956 cites W2122902308 @default.