Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942871539> ?p ?o ?g. }
- W2942871539 abstract "Inflammation has a crucial role in protection against various pathogens. The inflammasome, is an intracellular multiprotein signaling complex, that is linked to pathogen sensing and initiation of the inflammatory response in physiological and pathological conditions. The most characterized inflammasome is the NLRP3 inflammasome, which is a known sensor of cell stress and is tightly regulated in resting cells. However, altered regulation of the NLRP3 inflammasome is found in several pathological conditions, including autoimmune disease and cancer. NLRP3 expression was shown to be post transcriptionally regulated and multiple miRNA have been implicated in post-transcriptional regulation of the inflammasome. Therefore, in recent years, miRNA based post transcriptional control of NLRP3 has become a focus of much research, especially as a potential therapeutic approach. In this review, we provide a summary of the recent investigations on the role of miRNA in the post transcriptional control of the NLRP3 inflammasome, a key regulator of pro-inflammatory IL-1β and IL-18 cytokine production. Current approaches to targeting the inflammasome product were shown to be an effective treatment for diseases linked to NLRP3 overexpression. Although utilizing NLRP3 targeting miRNAs was shown to be a successful therapeutic approach in several animal models, their therapeutic application in patients remains to be determined." @default.
- W2942871539 created "2019-05-09" @default.
- W2942871539 creator A5013793851 @default.
- W2942871539 creator A5016588433 @default.
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- W2942871539 creator A5053619995 @default.
- W2942871539 creator A5066414193 @default.
- W2942871539 creator A5085937978 @default.
- W2942871539 date "2019-05-01" @default.
- W2942871539 modified "2023-10-14" @default.
- W2942871539 title "MicroRNA Post-transcriptional Regulation of the NLRP3 Inflammasome in Immunopathologies" @default.
- W2942871539 cites W1165775359 @default.
- W2942871539 cites W1225338349 @default.
- W2942871539 cites W144423133 @default.
- W2942871539 cites W1513095566 @default.
- W2942871539 cites W1514224413 @default.
- W2942871539 cites W1524848610 @default.
- W2942871539 cites W1528634627 @default.
- W2942871539 cites W1529674879 @default.
- W2942871539 cites W1531415074 @default.
- W2942871539 cites W1535504388 @default.
- W2942871539 cites W1547959173 @default.
- W2942871539 cites W1604827622 @default.
- W2942871539 cites W1625775686 @default.
- W2942871539 cites W1673514954 @default.
- W2942871539 cites W1677487429 @default.
- W2942871539 cites W1757224638 @default.
- W2942871539 cites W1789000265 @default.
- W2942871539 cites W1820249097 @default.
- W2942871539 cites W1825604636 @default.
- W2942871539 cites W1836365179 @default.
- W2942871539 cites W1894792769 @default.
- W2942871539 cites W1911381531 @default.
- W2942871539 cites W1916083974 @default.
- W2942871539 cites W1964253344 @default.
- W2942871539 cites W1965148582 @default.
- W2942871539 cites W1965607649 @default.
- W2942871539 cites W1966625479 @default.
- W2942871539 cites W1967046222 @default.
- W2942871539 cites W1967784427 @default.
- W2942871539 cites W1969072247 @default.
- W2942871539 cites W1969188594 @default.
- W2942871539 cites W1969396451 @default.
- W2942871539 cites W1969923705 @default.
- W2942871539 cites W1970436087 @default.
- W2942871539 cites W1971749380 @default.
- W2942871539 cites W1975012711 @default.
- W2942871539 cites W1975032025 @default.
- W2942871539 cites W1975145629 @default.
- W2942871539 cites W1975296966 @default.
- W2942871539 cites W1975437957 @default.
- W2942871539 cites W1977159891 @default.
- W2942871539 cites W1977884267 @default.
- W2942871539 cites W1978103336 @default.
- W2942871539 cites W1980388821 @default.
- W2942871539 cites W1981106016 @default.
- W2942871539 cites W1981837371 @default.
- W2942871539 cites W1984520240 @default.
- W2942871539 cites W1984936950 @default.
- W2942871539 cites W1985236996 @default.
- W2942871539 cites W1985313675 @default.
- W2942871539 cites W1985538633 @default.
- W2942871539 cites W1987463569 @default.
- W2942871539 cites W1990899125 @default.
- W2942871539 cites W1991927502 @default.
- W2942871539 cites W1992351167 @default.
- W2942871539 cites W1993728991 @default.
- W2942871539 cites W1993808715 @default.
- W2942871539 cites W1994167951 @default.
- W2942871539 cites W1994391392 @default.
- W2942871539 cites W1995924556 @default.
- W2942871539 cites W1996441871 @default.
- W2942871539 cites W1996729081 @default.
- W2942871539 cites W2000336618 @default.
- W2942871539 cites W2001160691 @default.
- W2942871539 cites W2002394315 @default.
- W2942871539 cites W2004161875 @default.
- W2942871539 cites W2004516435 @default.
- W2942871539 cites W2004913788 @default.
- W2942871539 cites W2005359428 @default.
- W2942871539 cites W2007432455 @default.
- W2942871539 cites W2007465432 @default.
- W2942871539 cites W2009004909 @default.
- W2942871539 cites W2009435405 @default.
- W2942871539 cites W2009800174 @default.
- W2942871539 cites W2013337875 @default.
- W2942871539 cites W2013494956 @default.
- W2942871539 cites W2013669259 @default.
- W2942871539 cites W2014028055 @default.
- W2942871539 cites W2014974499 @default.
- W2942871539 cites W2015449243 @default.
- W2942871539 cites W2018335518 @default.
- W2942871539 cites W2018607502 @default.
- W2942871539 cites W2020226973 @default.
- W2942871539 cites W2020441471 @default.
- W2942871539 cites W2022423369 @default.
- W2942871539 cites W2022765384 @default.
- W2942871539 cites W2024378513 @default.
- W2942871539 cites W2024716296 @default.
- W2942871539 cites W2027732533 @default.