Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942874637> ?p ?o ?g. }
- W2942874637 abstract "Viruses like influenza are infamous for their ability to adapt to new hosts. Retrospective studies of natural zoonoses and passaging in the lab have identified a modest number of host-adaptive mutations. However, it is unclear if these mutations represent all ways that influenza can adapt to a new host. Here we take a prospective approach to this question by completely mapping amino-acid mutations to the avian influenza virus polymerase protein PB2 that enhance growth in human cells. We identify numerous previously uncharacterized human-adaptive mutations. These mutations cluster on PB2’s surface, highlighting potential interfaces with host factors. Some previously uncharacterized adaptive mutations occur in avian-to-human transmission of H7N9 influenza, showing their importance for natural virus evolution. But other adaptive mutations do not occur in nature because they are inaccessible via single-nucleotide mutations. Overall, our work shows how selection at key molecular surfaces combines with evolutionary accessibility to shape viral host adaptation." @default.
- W2942874637 created "2019-05-09" @default.
- W2942874637 creator A5025387674 @default.
- W2942874637 creator A5025754076 @default.
- W2942874637 creator A5073348028 @default.
- W2942874637 creator A5076865790 @default.
- W2942874637 creator A5091068534 @default.
- W2942874637 date "2019-04-30" @default.
- W2942874637 modified "2023-09-30" @default.
- W2942874637 title "Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans" @default.
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