Matches in SemOpenAlex for { <https://semopenalex.org/work/W2942895849> ?p ?o ?g. }
- W2942895849 endingPage "1243" @default.
- W2942895849 startingPage "1227" @default.
- W2942895849 abstract "Cancer is the second leading cause of morbidity and mortality worldwide. Although chemotherapy and radiotherapy enhance the survival rate of cancerous patients but they have several acute toxic effects. Therefore, there is a need to search for new anticancer agents having better efficacy and lesser side effects. In this regard, herbal treatment is found to be a safe method for treating and preventing cancer. Here, an attempt has been made to screen some less explored medicinal plants like Ammania baccifera, Asclepias curassavica, Azadarichta indica, Butea monosperma, Croton tiglium, Hedera nepalensis, Jatropha curcas, Momordica charantia, Moringa oleifera, Psidium guajava, etc. having potent anticancer activity with minimum cytotoxic value (IC50 >3μM) and lesser or negligible toxicity. They are rich in active phytochemicals with a wide range of drug targets. In this study, these medicinal plants were evaluated for dose-dependent cytotoxicological studies via in vitro MTT assay and in vivo tumor models along with some more plants which are reported to have IC50 value in the range of 0.019-0.528 mg/ml. The findings indicate that these plants inhibit tumor growth by their antiproliferative, pro-apoptotic, anti-metastatic and anti-angiogenic molecular targets. They are widely used because of their easy availability, affordable price and having no or sometimes minimal side effects. This review provides a baseline for the discovery of anticancer drugs from medicinal plants having minimum cytotoxic value with minimal side effects and establishment of their analogues for the welfare of mankind." @default.
- W2942895849 created "2019-05-09" @default.
- W2942895849 creator A5045036082 @default.
- W2942895849 creator A5054481238 @default.
- W2942895849 creator A5059648116 @default.
- W2942895849 date "2019-08-22" @default.
- W2942895849 modified "2023-09-30" @default.
- W2942895849 title "Current Status and Future Perspective for Research on Medicinal Plants with Anticancerous Activity and Minimum Cytotoxic Value" @default.
- W2942895849 cites W1559245878 @default.
- W2942895849 cites W1963664265 @default.
- W2942895849 cites W1965834606 @default.
- W2942895849 cites W1966795241 @default.
- W2942895849 cites W1968154498 @default.
- W2942895849 cites W1968570471 @default.
- W2942895849 cites W1969681477 @default.
- W2942895849 cites W1972587518 @default.
- W2942895849 cites W1973512839 @default.
- W2942895849 cites W1973537705 @default.
- W2942895849 cites W1975573382 @default.
- W2942895849 cites W1975817336 @default.
- W2942895849 cites W1976366817 @default.
- W2942895849 cites W1979081904 @default.
- W2942895849 cites W1980697248 @default.
- W2942895849 cites W1981541381 @default.
- W2942895849 cites W1981645460 @default.
- W2942895849 cites W1983134103 @default.
- W2942895849 cites W1986490557 @default.
- W2942895849 cites W1986961983 @default.
- W2942895849 cites W1987500790 @default.
- W2942895849 cites W1987650787 @default.
- W2942895849 cites W1989074935 @default.
- W2942895849 cites W1991511142 @default.
- W2942895849 cites W1991717260 @default.
- W2942895849 cites W1994339716 @default.
- W2942895849 cites W1995758230 @default.
- W2942895849 cites W1996877920 @default.
- W2942895849 cites W1997608622 @default.
- W2942895849 cites W2002273681 @default.
- W2942895849 cites W2002967339 @default.
- W2942895849 cites W2003434965 @default.
- W2942895849 cites W2005154187 @default.
- W2942895849 cites W2006979012 @default.
- W2942895849 cites W2007489508 @default.
- W2942895849 cites W2008065584 @default.
- W2942895849 cites W2011592968 @default.
- W2942895849 cites W2013964539 @default.
- W2942895849 cites W2026070762 @default.
- W2942895849 cites W2027516572 @default.
- W2942895849 cites W2028300044 @default.
- W2942895849 cites W2032625527 @default.
- W2942895849 cites W2034252021 @default.
- W2942895849 cites W2036238650 @default.
- W2942895849 cites W2037140762 @default.
- W2942895849 cites W2038769814 @default.
- W2942895849 cites W2045770287 @default.
- W2942895849 cites W2046307093 @default.
- W2942895849 cites W2047456663 @default.
- W2942895849 cites W2048239525 @default.
- W2942895849 cites W2049782851 @default.
- W2942895849 cites W2050780123 @default.
- W2942895849 cites W2051233297 @default.
- W2942895849 cites W2053145506 @default.
- W2942895849 cites W2054620686 @default.
- W2942895849 cites W2054858177 @default.
- W2942895849 cites W2055029293 @default.
- W2942895849 cites W2055194666 @default.
- W2942895849 cites W2055303870 @default.
- W2942895849 cites W2055527562 @default.
- W2942895849 cites W2056077439 @default.
- W2942895849 cites W2056793355 @default.
- W2942895849 cites W2057411263 @default.
- W2942895849 cites W2057642417 @default.
- W2942895849 cites W2059000522 @default.
- W2942895849 cites W2059303642 @default.
- W2942895849 cites W2059603392 @default.
- W2942895849 cites W2060763754 @default.
- W2942895849 cites W2061801920 @default.
- W2942895849 cites W2063029716 @default.
- W2942895849 cites W2063057297 @default.
- W2942895849 cites W2063619099 @default.
- W2942895849 cites W2067835634 @default.
- W2942895849 cites W2068471435 @default.
- W2942895849 cites W2069293289 @default.
- W2942895849 cites W2069335687 @default.
- W2942895849 cites W2069933653 @default.
- W2942895849 cites W2072635941 @default.
- W2942895849 cites W2072754176 @default.
- W2942895849 cites W2073095285 @default.
- W2942895849 cites W2074806782 @default.
- W2942895849 cites W2075049202 @default.
- W2942895849 cites W2075096138 @default.
- W2942895849 cites W2075120196 @default.
- W2942895849 cites W2077566839 @default.
- W2942895849 cites W2077691407 @default.
- W2942895849 cites W2077796580 @default.
- W2942895849 cites W2078141449 @default.
- W2942895849 cites W2080678779 @default.
- W2942895849 cites W2084282937 @default.