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- W2942903437 abstract "This study aims at evaluating the mean eradication rate by a systematic compilation of the studies which involved the standard triple therapy (STT) in first-line Helicobacter pylori (Hp) eradication in Turkey over a period of 10 years between 2004 and 2013 using the meta-analysis method.The systematic compilation and meta-analysis were carried out according to the PRISMA standards defined in the Cochrane handbook. The results of full-text studies published in national and international journals in English and Turkish languages on Turkish population in a period of 10 years, from 2004 to 2013, are included in this study. The studies include open-label trials, controlled trials, treatment arms, and case series that included a triple therapy regimen consisting of standard doses of a proton pump inhibitor (PPI; omeprazole 20 mg BID, lansoprazole 30 mg BID, pantoprazole 40 mg BID, esomeprazole 40 mg BID, or rabeprazole 20 mg BID) along with clarithromycin 500 mg BID and amoxicillin 1 g BID for 7-14 days. They were scanned electronically via the search engines Google Scholar, PubMed, and the Turkish Medicine Index using specific keywords. The related keywords used were Turkey, Helicobacter pylori, infection, standard triple treatment, first-line therapy, eradication, omeprazole, lansoprazole, pantoprazole, rabeprazole, esomeprazole, clarithromycin, and amoxicillin. Studies carried out with adults were included in the evaluation. The publication year of the studies and the included number of patients, their age, gender, treatment duration (7, 10, and 14 days), and PPIs used were evaluated by two separate gastroenterologists and biostatisticians. Studies that used at least one reliable method (histology, urea breath test (UBT), or Helicobacter pylori stool antigen (HpSA) test) four weeks after completing the treatment for the control of Hp eradication were included. Only naive patients were accepted, and patients who had previously received eradication treatment were excluded. The effectiveness of the Hp eradication was analyzed using an intention-to-treat (ITT) or per-protocol (PP) analysis.The STT regime of 45 studies complying with the inclusion criteria was evaluated. A total of 3715 patients were included in the study. Of the 3010 patients whose gender information was available, 55% were women and 45% were men; the weighted age average given explicitly in the studies was 42.14±0.67. The treatment lasted for 14 days in 42 studies, for 7 days in six studies, and for 10 days in 1 study. The eradication rates evaluated according to the ITT and PP analyses were 60% (95% CI: 56%-63%) and 57% (95% CI: 51%-62%), respectively. The rates for 7 days of treatment were 57% (95% CI: 46%-68%) and 60% (95% CI: 51%-67%) and for 14 days of treatment were 60% (95% CI: 56%-63%) and 56% (95% CI: 50%-62%), respectively. The ITT eradication rate of the only 10-day study was 78% (95% CI: 66%-86%). In the meta-regression analysis, the treatment duration, PPI, age, and gender ratio (women/men) used for the ITT analysis had no effect. The gender ratio and age were not considered in this analysis because they were not clearly stated in studies using the PP analysis. The duration of treatment and the PPI used had no effect.A systematic meta-analysis of studies conducted during the period 2004-2013 in Turkey revealed that the rate of first-line Hp eradication using STT was unacceptably low, and the duration of treatment and PPI used made no difference." @default.
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- W2942903437 date "2019-05-03" @default.
- W2942903437 modified "2023-10-18" @default.
- W2942903437 title "Standard triple therapy in Helicobacter pylori eradication in Turkey: Systematic evaluation and meta-analysis of 10-year studies" @default.
- W2942903437 cites W140062333 @default.
- W2942903437 cites W1487725968 @default.
- W2942903437 cites W1593039067 @default.
- W2942903437 cites W1749767700 @default.
- W2942903437 cites W184898907 @default.
- W2942903437 cites W191246147 @default.
- W2942903437 cites W195398608 @default.
- W2942903437 cites W1965152695 @default.
- W2942903437 cites W1973810168 @default.
- W2942903437 cites W1974497208 @default.
- W2942903437 cites W1979958733 @default.
- W2942903437 cites W1984264452 @default.
- W2942903437 cites W1985370765 @default.
- W2942903437 cites W1994689525 @default.
- W2942903437 cites W2002121748 @default.
- W2942903437 cites W2003762568 @default.
- W2942903437 cites W2004282686 @default.
- W2942903437 cites W2010222355 @default.
- W2942903437 cites W2016056333 @default.
- W2942903437 cites W2018710977 @default.
- W2942903437 cites W2021148641 @default.
- W2942903437 cites W2025225587 @default.
- W2942903437 cites W2029340717 @default.
- W2942903437 cites W2040791813 @default.
- W2942903437 cites W2046676726 @default.
- W2942903437 cites W2048371740 @default.
- W2942903437 cites W2057483058 @default.
- W2942903437 cites W2060732620 @default.
- W2942903437 cites W2061938579 @default.
- W2942903437 cites W2063521898 @default.
- W2942903437 cites W2064116080 @default.
- W2942903437 cites W2064718026 @default.
- W2942903437 cites W2066327476 @default.
- W2942903437 cites W2067045315 @default.
- W2942903437 cites W2068361467 @default.
- W2942903437 cites W2068637245 @default.
- W2942903437 cites W2071687048 @default.
- W2942903437 cites W2076858077 @default.
- W2942903437 cites W2080933675 @default.
- W2942903437 cites W2084850669 @default.
- W2942903437 cites W2093135126 @default.
- W2942903437 cites W2096084654 @default.
- W2942903437 cites W2097401518 @default.
- W2942903437 cites W2097861406 @default.
- W2942903437 cites W2101730203 @default.
- W2942903437 cites W2106512383 @default.
- W2942903437 cites W2111942462 @default.
- W2942903437 cites W2125435699 @default.
- W2942903437 cites W2132370862 @default.
- W2942903437 cites W2134300124 @default.
- W2942903437 cites W2143448060 @default.
- W2942903437 cites W2152211277 @default.
- W2942903437 cites W2153165213 @default.
- W2942903437 cites W2163165680 @default.
- W2942903437 cites W2182805404 @default.
- W2942903437 cites W2188050548 @default.
- W2942903437 cites W2315514851 @default.
- W2942903437 cites W234674871 @default.
- W2942903437 cites W2382013981 @default.
- W2942903437 cites W2398031170 @default.
- W2942903437 cites W2416860197 @default.
- W2942903437 cites W249667438 @default.
- W2942903437 cites W253153242 @default.
- W2942903437 cites W25551450 @default.
- W2942903437 cites W2558680096 @default.
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- W2942903437 doi "https://doi.org/10.5152/tjg.2019.18693" @default.
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