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- W2942924328 abstract "Glycosylation alters protein form and function by establishing intermolecular forces that mediate specific interactions while preventing non-specific aggregation. Self-assembled peptide nanofibers modified with carbohydrates are increasingly used as biomaterials to mimic glycosylated protein function, yet the influence of carbohydrate conjugates on nanofiber structure remains poorly defined. Here we show that a dense carbohydrate surface layer can facilitate hierarchical organization of peptide nanofibers into anisotropic networks. Glycosylated peptide nanofibers remain dispersed in dilute conditions, whereas non-glycosylated nanofibers tend to aggregate. In crowded conditions, some glycosylated nanofibers laterally associate and align. This behavior depends on carbohydrate chemistry, particularly hydroxyls, suggesting involvement of short-range attractive forces. Macroscopic gels fabricated from densely glycosylated peptide nanofibers are resistant to non-specific interactions with proteins, mammalian cells, and bacteria, yet selectively bind lectins, analogous to natural low-fouling mucosal barriers. Collectively, these observations demonstrate that glycosylation can inform structure in addition to endowing function to peptide-based supramolecular biomaterials. Self-assembled glycopeptides are increasingly used as biomaterials. Here the self-assembly of glycosylated peptides under crowded conditions is shown to yield laterally aligned fibres which exhibit superior resistance towards non-specific binding of proteins and cells." @default.
- W2942924328 created "2019-05-09" @default.
- W2942924328 creator A5001372589 @default.
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- W2942924328 date "2019-05-06" @default.
- W2942924328 modified "2023-10-17" @default.
- W2942924328 title "Hierarchical self-assembly and emergent function of densely glycosylated peptide nanofibers" @default.
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- W2942924328 cites W1856532105 @default.
- W2942924328 cites W1964465710 @default.
- W2942924328 cites W1969438932 @default.
- W2942924328 cites W1975176845 @default.
- W2942924328 cites W1980911873 @default.
- W2942924328 cites W1981328149 @default.
- W2942924328 cites W1988305933 @default.
- W2942924328 cites W1989691970 @default.
- W2942924328 cites W1993159043 @default.
- W2942924328 cites W1995063875 @default.
- W2942924328 cites W1998608797 @default.
- W2942924328 cites W2009826592 @default.
- W2942924328 cites W2010316537 @default.
- W2942924328 cites W2016411740 @default.
- W2942924328 cites W2020611219 @default.
- W2942924328 cites W2023026872 @default.
- W2942924328 cites W2025890958 @default.
- W2942924328 cites W2027038277 @default.
- W2942924328 cites W2034560811 @default.
- W2942924328 cites W2048221161 @default.
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- W2942924328 cites W2074864118 @default.
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- W2942924328 cites W2086177318 @default.
- W2942924328 cites W2092328303 @default.
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- W2942924328 cites W2131922347 @default.
- W2942924328 cites W2134841721 @default.
- W2942924328 cites W2150766477 @default.
- W2942924328 cites W2152252241 @default.
- W2942924328 cites W2153147916 @default.
- W2942924328 cites W2154115123 @default.
- W2942924328 cites W2160171025 @default.
- W2942924328 cites W2161417492 @default.
- W2942924328 cites W2164505756 @default.
- W2942924328 cites W2168142115 @default.
- W2942924328 cites W2204953460 @default.
- W2942924328 cites W2213504946 @default.
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- W2942924328 cites W2290388934 @default.
- W2942924328 cites W2290512558 @default.
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- W2942924328 cites W2609578198 @default.
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- W2942924328 doi "https://doi.org/10.1038/s42004-019-0154-z" @default.
- W2942924328 hasPublicationYear "2019" @default.
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