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- W2942957114 endingPage "196" @default.
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- W2942957114 abstract "This review aims to introduce animal models of portal hypertension in which targets and drugs can be tested and presents current advances in the field of preclinical and early clinical settings. The interest in this field has risen in recent years and many promising targets and potential drugs have been tested in preclinical and early clinical studies. Most of these targets are intrahepatic and aim to decrease hepatic stellate cell activity, as this cell type mediates both fibrosis and portal hypertension. Liver cirrhosis with portal hypertension is a global health burden due to their complications. Besides that, there are only a few therapies available, those are ineffective in a large part of the patients. Therefore, novel targets and treatment options are vastly needed." @default.
- W2942957114 created "2019-05-09" @default.
- W2942957114 creator A5029282864 @default.
- W2942957114 creator A5030752242 @default.
- W2942957114 creator A5056621975 @default.
- W2942957114 creator A5058024088 @default.
- W2942957114 date "2019-04-30" @default.
- W2942957114 modified "2023-10-16" @default.
- W2942957114 title "Novel Targets and Drug Development in Portal Hypertension" @default.
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