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• W2942995057 startingPage "8804" @default.
• W2942995057 abstract "Inspired by natural biomineralization processes, a simple and universal strategy is introduced to construct a biomimetic nanoplatform for systemic codelivery of a nucleic acid therapeutic (G3139) and a chemotherapeutic drug doxorubicin (DOX). This codelivery system was synthesized through one-pot supramolecular self-assembly of G3139, DOX, and FeII ions through multiple coordination interactions, followed by an adapted surface mineralization with metal-organic frameworks. The resulting core-shell nanoparticles have uniform size, well-defined nanosphere structure, robust colloidal stability, ultrahigh drug loading efficiency and capacity, and precisely adjustable ratios of two therapeutic agents. The system can efficiently accumulate in the tumor, allowing for sensitive MRI detection and synergistical inhibition of tumor growth without apparent systemic toxicity." @default.
• W2942995057 created "2019-05-09" @default.
• W2942995057 creator A5027985907 @default.
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• W2942995057 date "2019-06-24" @default.
• W2942995057 modified "2023-10-17" @default.
• W2942995057 title "A Biomimetic Coordination Nanoplatform for Controlled Encapsulation and Delivery of Drug–Gene Combinations" @default.
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• W2942995057 doi "https://doi.org/10.1002/anie.201903417" @default.
• W2942995057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31033145" @default.
• W2942995057 hasPublicationYear "2019" @default.
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