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• W2943009125 abstract "Abstract In the course of biological properties of quinone derivatives, the N(H)-, S- and S,S-substituted-1,4-naphthoquinones were synthesized by reactions of 2,3-dichloro-1,4-naphthoquinone with different amines (2-morpholinoaniline, tert-butyl 4-aminobenzoate, 4-tert-butylbenzylamine, N-(3-aminopropyl)-2-pipecoline, 2-amino-5,6-dimethylbenzothiazole, N,N'-diphenyl-p-phenylenediamine) and thiolat (sodium 2-methyl-2-propanethiolate). All new products were characterized by MS-ESI, UV-Vis, FT-IR, 1 H NMR, 13 C NMR. The antiproliferative activities of these compounds on human cervical cancer (HeLa) cells were evaluated by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay. Although all derivatives inhibited cell growth, the most active compound was 2-(tert-butylthio)-3-chloronaphthalene-1,4-dione 5 (IC 50 =10.16 μM) against the HeLa cells." @default.
• W2943009125 created "2019-05-09" @default.
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• W2943009125 date "2019-04-24" @default.
• W2943009125 modified "2023-10-17" @default.
• W2943009125 title "Synthesis and antiproliferative evaluation of some 1,4-naphthoquinone derivatives against human cervical cancer cells" @default.
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• W2943009125 doi "https://doi.org/10.1515/chem-2019-0030" @default.
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