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• W2943035441 abstract "IgG antinuclear antibodies (ANAs) are a dominant feature of several autoimmune diseases. We previously showed that systemic lupus erythematosus (SLE) is characterized by increased ANA+ IgG plasmablasts/plasma cells (PCs) through aberrant IgG PC differentiation rather than an antigen-specific tolerance defect. Here, we aimed to understand the differentiation pathways resulting in ANA+ IgG PCs in SLE patients. We demonstrate distinct profiles of ANA+ antigen-experienced B cells in SLE patients, characterized by either a high frequency of PCs or a high frequency of IgG+ memory B cells. This classification of SLE patients was unrelated to disease activity and remained stable over time in almost all patients, suggesting minimal influence of disease activity. A similar classification applies to antigen-specific B cell subsets in mice following primary immunization with T-independent and T-dependent antigens as well as in lupus-prone mouse models (MRL/lpr and NZB/W). We further show that, in both lupus-prone mice and SLE patients, the classification correlates with the serum autoantibody profile. In this study, we identified B cell phenotypes that we propose reflect an extrafollicular pathway for PC differentiation or a germinal center pathway, respectively. The classification we propose can be used to stratify patients for longitudinal studies and clinical trials." @default.
• W2943035441 created "2019-05-09" @default.
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• W2943035441 date "2019-05-02" @default.
• W2943035441 modified "2023-09-26" @default.
• W2943035441 title "Patterns of ANA+ B cells for SLE patient stratification" @default.
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• W2943035441 doi "https://doi.org/10.1172/jci.insight.127885" @default.
• W2943035441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6538361" @default.
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• W2943035441 hasPublicationYear "2019" @default.
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