FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943044765> ?p ?o ?g. }

• W2943044765 endingPage "627" @default.
• W2943044765 startingPage "627" @default.
• W2943044765 abstract "Aberrant activation of hepatocyte growth factor (HGF)/c-Met signaling pathway caused by gene amplification or mutation plays an important role in tumorigenesis. Therefore, c-Met is considered as an attractive target for cancer therapy and c-Met inhibitors have been developed with great interests. However, cancers treated with c-Met inhibitors inevitably develop resistance commonly caused by the activation of PI3K/Akt signal transduction pathway. Therefore, the combination of c-Met and PI3Kα inhibitors showed synergistic activities, especially, in c-Met hyperactivated and PIK3CA-mutated cells. In our previous study, we rationally designed and synthesized DFX117(6-(5-(2,4-difluorophenylsulfonamido)-6-methoxypyridin-3-yl)-N-(2-morpholinoethyl) imidazo[1,2-a]pyridine-3-carboxamide) as a novel PI3Kα selective inhibitor. Herein, the antitumor activity and underlying mechanisms of DFX117 against non-small cell lung cancer (NSCLC) cells were evaluated in both in vitro and in vivo animal models. Concurrent targeted c-Met and PI3Kα by DFX117 dose-dependent inhibited the cell growth of H1975 cells (PIK3CA mutation and c-Met amplification) and A549 cells (KRAS mutation). DFX117 subsequently induced G0/G1 cell cycle arrest and apoptosis. These data highlight the significant potential of DFX117 as a feasible and efficacious agent for the treatment of NSCLC patients." @default.
• W2943044765 created "2019-05-09" @default.
• W2943044765 creator A5027490853 @default.
• W2943044765 creator A5028070229 @default.
• W2943044765 creator A5033086793 @default.
• W2943044765 creator A5049347603 @default.
• W2943044765 creator A5056278067 @default.
• W2943044765 creator A5059974101 @default.
• W2943044765 creator A5088666596 @default.
• W2943044765 date "2019-05-05" @default.
• W2943044765 modified "2023-09-27" @default.
• W2943044765 title "Antitumor Activity of DFX117 by Dual Inhibition of c-Met and PI3Kα in Non-Small Cell Lung Cancer" @default.
• W2943044765 cites W1522695374 @default.
• W2943044765 cites W1773377997 @default.
• W2943044765 cites W1862837539 @default.
• W2943044765 cites W1963497189 @default.
• W2943044765 cites W1977401929 @default.
• W2943044765 cites W1984041688 @default.
• W2943044765 cites W1998450601 @default.
• W2943044765 cites W2002246691 @default.
• W2943044765 cites W2006512961 @default.
• W2943044765 cites W2014506776 @default.
• W2943044765 cites W2030733555 @default.
• W2943044765 cites W2050211354 @default.
• W2943044765 cites W2054334049 @default.
• W2943044765 cites W2080080809 @default.
• W2943044765 cites W2095558022 @default.
• W2943044765 cites W2098763217 @default.
• W2943044765 cites W2101821132 @default.
• W2943044765 cites W2116327129 @default.
• W2943044765 cites W2121769182 @default.
• W2943044765 cites W2122895515 @default.
• W2943044765 cites W2125519805 @default.
• W2943044765 cites W2132657998 @default.
• W2943044765 cites W2140932756 @default.
• W2943044765 cites W2148971037 @default.
• W2943044765 cites W2155167580 @default.
• W2943044765 cites W2169477367 @default.
• W2943044765 cites W2191995810 @default.
• W2943044765 cites W2299551224 @default.
• W2943044765 cites W2329448478 @default.
• W2943044765 cites W2472419401 @default.
• W2943044765 cites W2502892549 @default.
• W2943044765 cites W2536747682 @default.
• W2943044765 cites W2605481248 @default.
• W2943044765 cites W2620079993 @default.
• W2943044765 cites W2740314095 @default.
• W2943044765 cites W2741681640 @default.
• W2943044765 cites W2793502153 @default.
• W2943044765 cites W2794026637 @default.
• W2943044765 cites W2810788886 @default.
• W2943044765 cites W2890564758 @default.
• W2943044765 doi "https://doi.org/10.3390/cancers11050627" @default.
• W2943044765 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6562471" @default.
• W2943044765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31060329" @default.
• W2943044765 hasPublicationYear "2019" @default.
• W2943044765 type Work @default.
• W2943044765 sameAs 2943044765 @default.
• W2943044765 citedByCount "15" @default.
• W2943044765 countsByYear W29430447652019 @default.
• W2943044765 countsByYear W29430447652020 @default.
• W2943044765 countsByYear W29430447652021 @default.
• W2943044765 countsByYear W29430447652022 @default.
• W2943044765 countsByYear W29430447652023 @default.
• W2943044765 crossrefType "journal-article" @default.
• W2943044765 hasAuthorship W2943044765A5027490853 @default.
• W2943044765 hasAuthorship W2943044765A5028070229 @default.
• W2943044765 hasAuthorship W2943044765A5033086793 @default.
• W2943044765 hasAuthorship W2943044765A5049347603 @default.
• W2943044765 hasAuthorship W2943044765A5056278067 @default.
• W2943044765 hasAuthorship W2943044765A5059974101 @default.
• W2943044765 hasAuthorship W2943044765A5088666596 @default.
• W2943044765 hasBestOaLocation W29430447651 @default.
• W2943044765 hasConcept C104317684 @default.
• W2943044765 hasConcept C121608353 @default.
• W2943044765 hasConcept C126322002 @default.
• W2943044765 hasConcept C170493617 @default.
• W2943044765 hasConcept C185592680 @default.
• W2943044765 hasConcept C2776256026 @default.
• W2943044765 hasConcept C2776996007 @default.
• W2943044765 hasConcept C2780467284 @default.
• W2943044765 hasConcept C2781187634 @default.
• W2943044765 hasConcept C2781230642 @default.
• W2943044765 hasConcept C29537977 @default.
• W2943044765 hasConcept C501734568 @default.
• W2943044765 hasConcept C502942594 @default.
• W2943044765 hasConcept C54355233 @default.
• W2943044765 hasConcept C555283112 @default.
• W2943044765 hasConcept C62112901 @default.
• W2943044765 hasConcept C62478195 @default.
• W2943044765 hasConcept C71924100 @default.
• W2943044765 hasConcept C75217442 @default.
• W2943044765 hasConcept C86554907 @default.
• W2943044765 hasConcept C86803240 @default.
• W2943044765 hasConcept C95444343 @default.
• W2943044765 hasConceptScore W2943044765C104317684 @default.
• W2943044765 hasConceptScore W2943044765C121608353 @default.
• W2943044765 hasConceptScore W2943044765C126322002 @default.

• next