Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943048265> ?p ?o ?g. }
- W2943048265 abstract "It is well-established that angiotensin II exerts a dampening effect on the baroreflex within the nucleus tractus solitarii (NTS), the principal brainstem site for termination of baroreceptor afferents and which is densely populated with gamma-aminobutyric acid (GABA)ergic neurons and nerve terminals. The present study was designed to investigate whether local release of GABA is involved in the effects mediated by local angiotensin II within the NTS.In vivo microdialysis was used for measurement of extracellular glutamate and GABA levels and for infusion of angiotensin II within the NTS of conscious normotensive Wistar rats. The mean arterial pressure (MAP) and heart rate response to local infusion of angiotensin II were subsequently monitored with a pressure transducer under anesthesia. The angiotensin II type 1 receptor (AT1R) antagonist, candesartan, was used to assess whether responses were AT1R dependent and the nitric oxide (NO) synthase inhibitor, N(ω)-nitro-L-arginine methyl ester (L-NAME), was used to assess the involvement of NO in the evoked responses by infusion of angiotensin II. The MAP and heart rate responses were monitored with a pressure transducer.Local infusion into the NTS of angiotensin II induced a significant to ninefold significantly increase in extracellular GABA levels; as well as MAP was increased by 15 mmHg. These responses were both abolished by co-infusion of either, the angiotensin II type 1 receptor antagonist, candesartan, or the NO synthase inhibitor, L-NAME, demonstrating that the effect is not only AT1R dependent but also NO dependent. The pressor response to angiotensin II was reversed by co-infusion with the GABAA receptor antagonist, bicuculline. Local blockade of NO synthase decreased both, GABA and glutamate concentrations.Our results suggest that the AT1R mediated hypertensive response to angiotensin II within the NTS in normotensive rats is GABA and NO dependent. Nitric oxide produced within the NTS tonically potentiates local GABA and glutamate release." @default.
- W2943048265 created "2019-05-09" @default.
- W2943048265 creator A5058611157 @default.
- W2943048265 creator A5073234756 @default.
- W2943048265 creator A5090159945 @default.
- W2943048265 date "2019-05-03" @default.
- W2943048265 modified "2023-09-27" @default.
- W2943048265 title "AT1 Receptor Mediated Hypertensive Response to Ang II in the Nucleus Tractus Solitarii of Normotensive Rats Involves NO Dependent Local GABA Release" @default.
- W2943048265 cites W1651614883 @default.
- W2943048265 cites W1762259017 @default.
- W2943048265 cites W1824110706 @default.
- W2943048265 cites W1922784661 @default.
- W2943048265 cites W1962928978 @default.
- W2943048265 cites W1966409424 @default.
- W2943048265 cites W1969442403 @default.
- W2943048265 cites W1969922285 @default.
- W2943048265 cites W1972140533 @default.
- W2943048265 cites W1974957909 @default.
- W2943048265 cites W1975156456 @default.
- W2943048265 cites W1975180184 @default.
- W2943048265 cites W1978340513 @default.
- W2943048265 cites W1978749598 @default.
- W2943048265 cites W1980063546 @default.
- W2943048265 cites W2003490751 @default.
- W2943048265 cites W2004327287 @default.
- W2943048265 cites W2007886276 @default.
- W2943048265 cites W2017958722 @default.
- W2943048265 cites W2020739776 @default.
- W2943048265 cites W2025303001 @default.
- W2943048265 cites W2026629747 @default.
- W2943048265 cites W2031600321 @default.
- W2943048265 cites W2040054030 @default.
- W2943048265 cites W2049069390 @default.
- W2943048265 cites W2050044131 @default.
- W2943048265 cites W2051979931 @default.
- W2943048265 cites W2052149243 @default.
- W2943048265 cites W2058784273 @default.
- W2943048265 cites W2068232307 @default.
- W2943048265 cites W2068757065 @default.
- W2943048265 cites W2069447865 @default.
- W2943048265 cites W2070530394 @default.
- W2943048265 cites W2071482392 @default.
- W2943048265 cites W2073113909 @default.
- W2943048265 cites W2075521716 @default.
- W2943048265 cites W2092274669 @default.
- W2943048265 cites W2093978015 @default.
- W2943048265 cites W2098688920 @default.
- W2943048265 cites W2104966233 @default.
- W2943048265 cites W2107718485 @default.
- W2943048265 cites W2108177961 @default.
- W2943048265 cites W2112016861 @default.
- W2943048265 cites W2130736859 @default.
- W2943048265 cites W2140916542 @default.
- W2943048265 cites W2145475206 @default.
- W2943048265 cites W2159030373 @default.
- W2943048265 cites W2163824042 @default.
- W2943048265 cites W2169584791 @default.
- W2943048265 cites W2180040417 @default.
- W2943048265 cites W2186881637 @default.
- W2943048265 cites W2216384435 @default.
- W2943048265 cites W2218264248 @default.
- W2943048265 cites W2236271024 @default.
- W2943048265 cites W2313451336 @default.
- W2943048265 cites W2625447274 @default.
- W2943048265 cites W2737890831 @default.
- W2943048265 cites W4296816736 @default.
- W2943048265 doi "https://doi.org/10.3389/fphar.2019.00460" @default.
- W2943048265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6509664" @default.
- W2943048265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31130861" @default.
- W2943048265 hasPublicationYear "2019" @default.
- W2943048265 type Work @default.
- W2943048265 sameAs 2943048265 @default.
- W2943048265 citedByCount "11" @default.
- W2943048265 countsByYear W29430482652019 @default.
- W2943048265 countsByYear W29430482652020 @default.
- W2943048265 countsByYear W29430482652022 @default.
- W2943048265 countsByYear W29430482652023 @default.
- W2943048265 crossrefType "journal-article" @default.
- W2943048265 hasAuthorship W2943048265A5058611157 @default.
- W2943048265 hasAuthorship W2943048265A5073234756 @default.
- W2943048265 hasAuthorship W2943048265A5090159945 @default.
- W2943048265 hasBestOaLocation W29430482651 @default.
- W2943048265 hasConcept C104849204 @default.
- W2943048265 hasConcept C123915805 @default.
- W2943048265 hasConcept C126322002 @default.
- W2943048265 hasConcept C134018914 @default.
- W2943048265 hasConcept C170493617 @default.
- W2943048265 hasConcept C185592680 @default.
- W2943048265 hasConcept C191237925 @default.
- W2943048265 hasConcept C198710026 @default.
- W2943048265 hasConcept C2776452961 @default.
- W2943048265 hasConcept C2777622882 @default.
- W2943048265 hasConcept C2777953023 @default.
- W2943048265 hasConcept C2779929655 @default.
- W2943048265 hasConcept C2780036600 @default.
- W2943048265 hasConcept C2908560794 @default.
- W2943048265 hasConcept C2908929049 @default.
- W2943048265 hasConcept C33114225 @default.
- W2943048265 hasConcept C50156730 @default.
- W2943048265 hasConcept C519581460 @default.