FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943075758> ?p ?o ?g. }

• W2943075758 endingPage "593" @default.
• W2943075758 startingPage "587" @default.
• W2943075758 abstract "BackgroundAutoimmunity and allergy have been associated with decreased number and function of regulatory T-cells (Tregs) and low interleukin-2 (IL-2) levels. We aimed to investigate if the release of IL-2 from peripheral blood mononuclear cells (PBMCs) stimulated with pathogenic airway bacteria was associated with development of allergy-outcomes in early childhood.MethodsPBMCs were isolated at age 6 months in 331 infants from the Copenhagen Prospective Studies on Asthma in Childhood 2000 (COPSAC2000) mother-child cohort, and subsequently stimulated with H. influenzae, M. catarrhalis and S. pneumoniae in in vitro cultures. Levels of cytokines (IL-2, IL-10, IFN-γ, TNF-α, IL-5, IL-13 and IL-17A) were determined in the supernatant by electrochemiluminescence immunoassays. The immune profiles were analyzed for association with development of total-IgE, allergic sensitization and rhinitis during the first 7 years of life using regression models and principal component analysis (PCA).FindingsAn attenuated IL-2 response to stimulation with H. influenzae (p = 0∙011) and M. catarrhalis (p = 0∙027) was associated with elevated total-IgE at age 7, which was confirmed in a multivariate PCA model including all cytokine measurements (PC2, p = 0∙032). An immune profile with both reduced IL-2 and elevated IL-5 was associated with increased risk of allergic rhinitis (PC3, p = 0∙038). We found no associations with development of allergic sensitization.InterpretationA reduced IL-2 response from PBMCs exposed to common pathogenic airway bacteria at age 6 months was associated with elevated total-IgE and allergic rhinitis during the first 7 years of life. These findings suggest that suppressed Treg activity in early life may herald onset of allergy in early childhood, which could be a target for low-dose IL-2 trials in the future.FundCOPSAC is funded by private and public research funds all listed on www.copsac.com." @default.
• W2943075758 created "2019-05-09" @default.
• W2943075758 creator A5005675278 @default.
• W2943075758 creator A5013346955 @default.
• W2943075758 creator A5013746019 @default.
• W2943075758 creator A5014990556 @default.
• W2943075758 creator A5031414961 @default.
• W2943075758 creator A5034319171 @default.
• W2943075758 creator A5050384418 @default.
• W2943075758 creator A5056416945 @default.
• W2943075758 creator A5081281256 @default.
• W2943075758 creator A5087132565 @default.
• W2943075758 date "2019-05-01" @default.
• W2943075758 modified "2023-10-12" @default.
• W2943075758 title "Reduced IL-2 response from peripheral blood mononuclear cells exposed to bacteria at 6 months of age is associated with elevated total-IgE and allergic rhinitis during the first 7 years of life" @default.
• W2943075758 cites W1518759830 @default.
• W2943075758 cites W1661416591 @default.
• W2943075758 cites W1977680996 @default.
• W2943075758 cites W1991550944 @default.
• W2943075758 cites W2004510098 @default.
• W2943075758 cites W2010928181 @default.
• W2943075758 cites W2022373534 @default.
• W2943075758 cites W2031413047 @default.
• W2943075758 cites W2034082915 @default.
• W2943075758 cites W2039062116 @default.
• W2943075758 cites W2044249078 @default.
• W2943075758 cites W2044763085 @default.
• W2943075758 cites W2057192777 @default.
• W2943075758 cites W2062592266 @default.
• W2943075758 cites W2068639447 @default.
• W2943075758 cites W2085106134 @default.
• W2943075758 cites W2099613679 @default.
• W2943075758 cites W2106107076 @default.
• W2943075758 cites W2110389012 @default.
• W2943075758 cites W2117613892 @default.
• W2943075758 cites W2122722718 @default.
• W2943075758 cites W2130778427 @default.
• W2943075758 cites W2152259491 @default.
• W2943075758 cites W2165736320 @default.
• W2943075758 cites W2215012640 @default.
• W2943075758 cites W2235440013 @default.
• W2943075758 cites W2317366553 @default.
• W2943075758 cites W2343597029 @default.
• W2943075758 cites W2418462204 @default.
• W2943075758 cites W2737785069 @default.
• W2943075758 cites W2795839893 @default.
• W2943075758 cites W2924644564 @default.
• W2943075758 doi "https://doi.org/10.1016/j.ebiom.2019.04.047" @default.
• W2943075758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6558232" @default.
• W2943075758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31056472" @default.
• W2943075758 hasPublicationYear "2019" @default.
• W2943075758 type Work @default.
• W2943075758 sameAs 2943075758 @default.
• W2943075758 citedByCount "9" @default.
• W2943075758 countsByYear W29430757582019 @default.
• W2943075758 countsByYear W29430757582020 @default.
• W2943075758 countsByYear W29430757582022 @default.
• W2943075758 countsByYear W29430757582023 @default.
• W2943075758 crossrefType "journal-article" @default.
• W2943075758 hasAuthorship W2943075758A5005675278 @default.
• W2943075758 hasAuthorship W2943075758A5013346955 @default.
• W2943075758 hasAuthorship W2943075758A5013746019 @default.
• W2943075758 hasAuthorship W2943075758A5014990556 @default.
• W2943075758 hasAuthorship W2943075758A5031414961 @default.
• W2943075758 hasAuthorship W2943075758A5034319171 @default.
• W2943075758 hasAuthorship W2943075758A5050384418 @default.
• W2943075758 hasAuthorship W2943075758A5056416945 @default.
• W2943075758 hasAuthorship W2943075758A5081281256 @default.
• W2943075758 hasAuthorship W2943075758A5087132565 @default.
• W2943075758 hasBestOaLocation W29430757581 @default.
• W2943075758 hasConcept C137061746 @default.
• W2943075758 hasConcept C141105273 @default.
• W2943075758 hasConcept C159654299 @default.
• W2943075758 hasConcept C202751555 @default.
• W2943075758 hasConcept C203014093 @default.
• W2943075758 hasConcept C207480886 @default.
• W2943075758 hasConcept C2776042228 @default.
• W2943075758 hasConcept C2776217527 @default.
• W2943075758 hasConcept C2778690821 @default.
• W2943075758 hasConcept C55493867 @default.
• W2943075758 hasConcept C71924100 @default.
• W2943075758 hasConcept C74172505 @default.
• W2943075758 hasConcept C86803240 @default.
• W2943075758 hasConcept C8891405 @default.
• W2943075758 hasConceptScore W2943075758C137061746 @default.
• W2943075758 hasConceptScore W2943075758C141105273 @default.
• W2943075758 hasConceptScore W2943075758C159654299 @default.
• W2943075758 hasConceptScore W2943075758C202751555 @default.
• W2943075758 hasConceptScore W2943075758C203014093 @default.
• W2943075758 hasConceptScore W2943075758C207480886 @default.
• W2943075758 hasConceptScore W2943075758C2776042228 @default.
• W2943075758 hasConceptScore W2943075758C2776217527 @default.
• W2943075758 hasConceptScore W2943075758C2778690821 @default.
• W2943075758 hasConceptScore W2943075758C55493867 @default.
• W2943075758 hasConceptScore W2943075758C71924100 @default.
• W2943075758 hasConceptScore W2943075758C74172505 @default.
• W2943075758 hasConceptScore W2943075758C86803240 @default.
• W2943075758 hasConceptScore W2943075758C8891405 @default.

• next