FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943089168> ?p ?o ?g. }

• W2943089168 abstract "The membrane dopamine transporter (DAT) is involved in a number of brain disorders and its exploration by positron emission tomography (PET) imaging is highly relevant for the early and differential diagnosis, follow-up and treatment assessment of these diseases. A number of carbon-11 and fluor-18 labeled tracers are to date available for this aim, the majority of them being derived from the chemical structure of cocaine. The development of such a tracer, from its conception to its use, is a long process, the expected result being to obtain the best radiopharmaceutical adapted for clinical protocols. In this context, the cocaine derivative (E)-N-(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4’-tolyl)nortropane, or LBT-999, has passed all the required stages of the development that makes it now a highly relevant imaging tool, particularly in the context of Parkinson’s disease. This review describes the different steps of the development of LBT-999 which initially came from its non-fluorinated derivative (E)-N-(3-iodoprop-2-enyl)-2-carbomethoxy-3-(4-methylphenyl) nortropane, or PE2I, because of its high promising properties. [18F]LBT-999 has been extensively characterized in rodent and non-human primate models, in which its demonstrated its capability to explore in vivo the DAT localized at the dopaminergic nerve endings as well as at the mesencephalic cell bodies, in physiological conditions. In lesion-induced rat models of Parkinson’s disease, [18F]LBT-999 was able to precisely quantify in vivo the dopaminergic neuron loss, and to assess the beneficial effects of therapeutic approaches such as pharmacological treatment and cell transplantation. Finally recent clinical data demonstrated the efficiency of [18F]LBT-999 in the diagnosis of Parkinson’s disease." @default.
• W2943089168 created "2019-05-09" @default.
• W2943089168 creator A5028207329 @default.
• W2943089168 creator A5029970900 @default.
• W2943089168 creator A5045793605 @default.
• W2943089168 creator A5054809478 @default.
• W2943089168 creator A5059375704 @default.
• W2943089168 creator A5068537810 @default.
• W2943089168 creator A5071976833 @default.
• W2943089168 creator A5085252409 @default.
• W2943089168 creator A5087581125 @default.
• W2943089168 creator A5087658253 @default.
• W2943089168 creator A5089079526 @default.
• W2943089168 date "2019-05-03" @default.
• W2943089168 modified "2023-10-09" @default.
• W2943089168 title "The Story of the Dopamine Transporter PET Tracer LBT-999: From Conception to Clinical Use" @default.
• W2943089168 cites W1893875429 @default.
• W2943089168 cites W1929760471 @default.
• W2943089168 cites W1977154733 @default.
• W2943089168 cites W1977687697 @default.
• W2943089168 cites W1983779361 @default.
• W2943089168 cites W2024841068 @default.
• W2943089168 cites W2033150739 @default.
• W2943089168 cites W2041210568 @default.
• W2943089168 cites W2055779291 @default.
• W2943089168 cites W2057335179 @default.
• W2943089168 cites W2063061352 @default.
• W2943089168 cites W2066870719 @default.
• W2943089168 cites W2082168061 @default.
• W2943089168 cites W2087944418 @default.
• W2943089168 cites W2096624149 @default.
• W2943089168 cites W2101986330 @default.
• W2943089168 cites W2122547107 @default.
• W2943089168 cites W2132489587 @default.
• W2943089168 cites W2143747410 @default.
• W2943089168 cites W2149046471 @default.
• W2943089168 cites W2151128435 @default.
• W2943089168 cites W2160874664 @default.
• W2943089168 cites W2162335170 @default.
• W2943089168 cites W2287601811 @default.
• W2943089168 cites W2587577326 @default.
• W2943089168 cites W2749422257 @default.
• W2943089168 cites W2761589214 @default.
• W2943089168 cites W2801106285 @default.
• W2943089168 cites W2889012682 @default.
• W2943089168 cites W2898316543 @default.
• W2943089168 cites W2901338096 @default.
• W2943089168 cites W2901343410 @default.
• W2943089168 cites W2901489210 @default.
• W2943089168 cites W2901905026 @default.
• W2943089168 cites W2928980871 @default.
• W2943089168 cites W2952462837 @default.
• W2943089168 cites W4248645062 @default.
• W2943089168 cites W4256196726 @default.
• W2943089168 doi "https://doi.org/10.3389/fmed.2019.00090" @default.
• W2943089168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6509245" @default.
• W2943089168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31131278" @default.
• W2943089168 hasPublicationYear "2019" @default.
• W2943089168 type Work @default.
• W2943089168 sameAs 2943089168 @default.
• W2943089168 citedByCount "11" @default.
• W2943089168 countsByYear W29430891682020 @default.
• W2943089168 countsByYear W29430891682021 @default.
• W2943089168 countsByYear W29430891682022 @default.
• W2943089168 countsByYear W29430891682023 @default.
• W2943089168 crossrefType "journal-article" @default.
• W2943089168 hasAuthorship W2943089168A5028207329 @default.
• W2943089168 hasAuthorship W2943089168A5029970900 @default.
• W2943089168 hasAuthorship W2943089168A5045793605 @default.
• W2943089168 hasAuthorship W2943089168A5054809478 @default.
• W2943089168 hasAuthorship W2943089168A5059375704 @default.
• W2943089168 hasAuthorship W2943089168A5068537810 @default.
• W2943089168 hasAuthorship W2943089168A5071976833 @default.
• W2943089168 hasAuthorship W2943089168A5085252409 @default.
• W2943089168 hasAuthorship W2943089168A5087581125 @default.
• W2943089168 hasAuthorship W2943089168A5087658253 @default.
• W2943089168 hasAuthorship W2943089168A5089079526 @default.
• W2943089168 hasBestOaLocation W29430891681 @default.
• W2943089168 hasConcept C137183658 @default.
• W2943089168 hasConcept C142724271 @default.
• W2943089168 hasConcept C150903083 @default.
• W2943089168 hasConcept C151730666 @default.
• W2943089168 hasConcept C15744967 @default.
• W2943089168 hasConcept C169760540 @default.
• W2943089168 hasConcept C185592680 @default.
• W2943089168 hasConcept C207001950 @default.
• W2943089168 hasConcept C2775842073 @default.
• W2943089168 hasConcept C2776755682 @default.
• W2943089168 hasConcept C2779343474 @default.
• W2943089168 hasConcept C2989005 @default.
• W2943089168 hasConcept C513476851 @default.
• W2943089168 hasConcept C71924100 @default.
• W2943089168 hasConcept C86803240 @default.
• W2943089168 hasConcept C98274493 @default.
• W2943089168 hasConceptScore W2943089168C137183658 @default.
• W2943089168 hasConceptScore W2943089168C142724271 @default.
• W2943089168 hasConceptScore W2943089168C150903083 @default.
• W2943089168 hasConceptScore W2943089168C151730666 @default.
• W2943089168 hasConceptScore W2943089168C15744967 @default.
• W2943089168 hasConceptScore W2943089168C169760540 @default.

• next