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- W2943101317 abstract "It is very much appreciated that the correspondence of Betancur and Gomez-Puerta1 calls for attention for the clinical relevance of mitotic patterns observed in HEp-2 indirect immunofluorescence assays (IIFA). Indeed, in the recent publication of the International Consensus on ANA Patterns (ICAP) consortium, it is concluded that the clinical relevance of the mitotic patterns is limited.2 With exception of the Nuclear Mitotic Apparatus (NuMA)-like pattern (anti-cellular (AC)-26), there is not much available evidence that these patterns clearly hint at a particular clinical manifestation. For the NuMA-like pattern, there is formal evidence that approximately one-half of the patients have clinical features of a systemic autoimmune disease, especially Sjogren’s syndrome, polymyalgia rheumatica, systemic lupus erythematosus, polymyositis and autoimmune hepatitis.3 ICAP initially defined 28 patterns ordered in a classification tree based on nuclear, cytoplasmic or mitotic reactivity of autoantibodies on HEp-2 cells.4 Subsequently, the nuclear Topo I-like pattern (AC-29) was added,5 and the codes AC-0 and AC-XX were given to negative results or undefined patterns, respectively.6 The international consensus, as defined in the …" @default.
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- W2943101317 date "2019-04-29" @default.
- W2943101317 modified "2023-10-03" @default.
- W2943101317 title "Response to: ‘Antinuclear antibodies: mitotic patterns and their clinical associations’ by Betancur and Gómez-Puerta" @default.
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- W2943101317 doi "https://doi.org/10.1136/annrheumdis-2019-215439" @default.
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