FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943135086> ?p ?o ?g. }

• W2943135086 endingPage "111" @default.
• W2943135086 startingPage "104" @default.
• W2943135086 abstract "Early inflammatory processes may play an important role in the development of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Experimental studies suggest that anti-inflammatory and membrane-stabilizing drugs might have beneficial effects, although the underlying mechanisms are not fully understood. The aim of this study was to investigate the effect of early treatment with methylprednisolone and minocycline on cerebral perfusion and EBI after experimental SAH.Male Sprague-Dawley rats were subjected to SAH using the endovascular filament model. 30 minutes after SAH, they were randomly assigned to receive an intravenous injection of methylprednisolone (16mg/kg body weight, n=10), minocycline (45mg/kg body weight, n=10) or saline (n=11). Mean arterial blood pressure (MABP), intracranial pressure (ICP) and local cerebral blood flow (LCBF) over both hemispheres were recorded continuously for three hours following SAH. Neurological assessment was performed after 24 hours. Hippocampal damage was analyzed by immunohistochemical staining (caspase 3).Treatment with methylprednisolone or minocycline did not result in a significant improvement of MABP, ICP or LCBF. Animals of both treatment groups showed a non-significant trend to better neurological recovery compared to animals of the control group. Mortality was reduced and hippocampal damage significantly attenuated in both methylprednisolone and minocycline treated animals.The results of this study suggest that inflammatory processes may play an important role in the pathophysiology of EBI after SAH. Early treatment with the anti-inflammatory drugs methylprednisolone or minocycline in the acute phase of SAH has the potential to reduce brain damage and exert a neuroprotective effect." @default.
• W2943135086 created "2019-05-09" @default.
• W2943135086 creator A5000446006 @default.
• W2943135086 creator A5012871144 @default.
• W2943135086 creator A5018022781 @default.
• W2943135086 creator A5036019319 @default.
• W2943135086 creator A5043065066 @default.
• W2943135086 creator A5056537404 @default.
• W2943135086 date "2019-04-23" @default.
• W2943135086 modified "2023-10-12" @default.
• W2943135086 title "Early antiinflammatory therapy attenuates brain damage after sah in rats" @default.
• W2943135086 cites W125615523 @default.
• W2943135086 cites W131096790 @default.
• W2943135086 cites W1484098248 @default.
• W2943135086 cites W1504924755 @default.
• W2943135086 cites W1542205514 @default.
• W2943135086 cites W154666106 @default.
• W2943135086 cites W1628962302 @default.
• W2943135086 cites W1643384450 @default.
• W2943135086 cites W1923366023 @default.
• W2943135086 cites W1967016288 @default.
• W2943135086 cites W1968822217 @default.
• W2943135086 cites W1971061414 @default.
• W2943135086 cites W1973198957 @default.
• W2943135086 cites W1982831136 @default.
• W2943135086 cites W1990542484 @default.
• W2943135086 cites W2004309874 @default.
• W2943135086 cites W2004362945 @default.
• W2943135086 cites W2008168566 @default.
• W2943135086 cites W2013900800 @default.
• W2943135086 cites W2019859601 @default.
• W2943135086 cites W2023520406 @default.
• W2943135086 cites W2026816336 @default.
• W2943135086 cites W2027476258 @default.
• W2943135086 cites W2030613585 @default.
• W2943135086 cites W2032134195 @default.
• W2943135086 cites W2035242351 @default.
• W2943135086 cites W203545144 @default.
• W2943135086 cites W2046926560 @default.
• W2943135086 cites W2048766205 @default.
• W2943135086 cites W2049562713 @default.
• W2943135086 cites W2049817176 @default.
• W2943135086 cites W2057831907 @default.
• W2943135086 cites W2058644028 @default.
• W2943135086 cites W2058779913 @default.
• W2943135086 cites W2081534285 @default.
• W2943135086 cites W2082872000 @default.
• W2943135086 cites W2093536482 @default.
• W2943135086 cites W2098594396 @default.
• W2943135086 cites W2102182787 @default.
• W2943135086 cites W2113617025 @default.
• W2943135086 cites W2114862320 @default.
• W2943135086 cites W2117427121 @default.
• W2943135086 cites W2120636630 @default.
• W2943135086 cites W2130655643 @default.
• W2943135086 cites W2133961780 @default.
• W2943135086 cites W2150626397 @default.
• W2943135086 cites W2157744411 @default.
• W2943135086 cites W2166069631 @default.
• W2943135086 cites W2286903127 @default.
• W2943135086 cites W2329390166 @default.
• W2943135086 cites W2350189493 @default.
• W2943135086 cites W2423888063 @default.
• W2943135086 cites W2501836428 @default.
• W2943135086 cites W2588810958 @default.
• W2943135086 cites W2797732082 @default.
• W2943135086 cites W2522784070 @default.
• W2943135086 doi "https://doi.org/10.1515/tnsci-2019-0018" @default.
• W2943135086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6487785" @default.
• W2943135086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31098320" @default.
• W2943135086 hasPublicationYear "2019" @default.
• W2943135086 type Work @default.
• W2943135086 sameAs 2943135086 @default.
• W2943135086 citedByCount "3" @default.
• W2943135086 countsByYear W29431350862020 @default.
• W2943135086 countsByYear W29431350862021 @default.
• W2943135086 crossrefType "journal-article" @default.
• W2943135086 hasAuthorship W2943135086A5000446006 @default.
• W2943135086 hasAuthorship W2943135086A5012871144 @default.
• W2943135086 hasAuthorship W2943135086A5018022781 @default.
• W2943135086 hasAuthorship W2943135086A5036019319 @default.
• W2943135086 hasAuthorship W2943135086A5043065066 @default.
• W2943135086 hasAuthorship W2943135086A5056537404 @default.
• W2943135086 hasBestOaLocation W29431350861 @default.
• W2943135086 hasConcept C118552586 @default.
• W2943135086 hasConcept C126322002 @default.
• W2943135086 hasConcept C148762608 @default.
• W2943135086 hasConcept C154281038 @default.
• W2943135086 hasConcept C157767197 @default.
• W2943135086 hasConcept C25498285 @default.
• W2943135086 hasConcept C2777397205 @default.
• W2943135086 hasConcept C2777736543 @default.
• W2943135086 hasConcept C2778275353 @default.
• W2943135086 hasConcept C2780372218 @default.
• W2943135086 hasConcept C2780954326 @default.
• W2943135086 hasConcept C2781017439 @default.
• W2943135086 hasConcept C42219234 @default.
• W2943135086 hasConcept C501593827 @default.

• next