FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943216063> ?p ?o ?g. }

• W2943216063 endingPage "498" @default.
• W2943216063 startingPage "488" @default.
• W2943216063 abstract "The increased incidence of testicular disorders in young men and the possible influence of environmental chemicals, such as dibutyl phthalate (DBP) and acrylamide (AA), requires experimental models for identifying modes of action. Most published reproductive toxicologic studies use RNA samples from the total testis to evaluate testicular gene expression; however, analyses of isolated cell types could provide a more specific tool. Among testicular germ cells, spermatogonia are critical since they represent the onset of spermatogenesis. This study aimed, (1) to establish a technique for spermatogonia isolation; (2) to apply this isolation technique to verify possible gene expression alterations (Pou5f1, Kitlg, Mki-67, Bak1 and Spry4) in prepubertal post-natal day, (PND24) and pubertal (PND45) testes after in utero and postnatal exposure to DBP or AA. The technique was efficient for isolation of a majority of spermatogonia. In utero DBP exposure led to reduced litter body weight at birth, reduced anogenital distance of male pups on PND4, and increased frequency of male nipple retention on PND14 compared to controls. DBP-exposed relative testes weights were reduced only at PND24 compared to control but they did not differ at PND45. DBP-exposed animals showed reduced expression levels of Pou5f1 and Mki67 on PND24, and reduced expression of Pou5f1 and Spry4 on PND45. AA exposure reduced expression of Pou5f1, Mki67, and Spry4 at PND45 although not significantly. Our results suggest that DBP acts by reducing cell proliferation and impairing differentiation in prepubertal and pubertal testes." @default.
• W2943216063 created "2019-05-09" @default.
• W2943216063 creator A5009972348 @default.
• W2943216063 creator A5011471622 @default.
• W2943216063 creator A5014590960 @default.
• W2943216063 creator A5024906356 @default.
• W2943216063 creator A5029395581 @default.
• W2943216063 creator A5040573905 @default.
• W2943216063 creator A5051619050 @default.
• W2943216063 date "2019-06-18" @default.
• W2943216063 modified "2023-10-03" @default.
• W2943216063 title "Isolation and molecular characterization of spermatogonia from male Sprague-Dawley rats exposed <i>in utero</i> and postnatally to dibutyl phthalate or acrylamide" @default.
• W2943216063 cites W103436795 @default.
• W2943216063 cites W1605987518 @default.
• W2943216063 cites W1812804757 @default.
• W2943216063 cites W1864600093 @default.
• W2943216063 cites W1971446901 @default.
• W2943216063 cites W1972850991 @default.
• W2943216063 cites W1974082627 @default.
• W2943216063 cites W1977825177 @default.
• W2943216063 cites W1978802056 @default.
• W2943216063 cites W1983104870 @default.
• W2943216063 cites W1990338377 @default.
• W2943216063 cites W2005771621 @default.
• W2943216063 cites W2011748718 @default.
• W2943216063 cites W2019668373 @default.
• W2943216063 cites W2024159010 @default.
• W2943216063 cites W2024962109 @default.
• W2943216063 cites W2025716845 @default.
• W2943216063 cites W2039882483 @default.
• W2943216063 cites W2042938906 @default.
• W2943216063 cites W2044273377 @default.
• W2943216063 cites W2045307818 @default.
• W2943216063 cites W2046487222 @default.
• W2943216063 cites W2055227245 @default.
• W2943216063 cites W2058759573 @default.
• W2943216063 cites W2062614245 @default.
• W2943216063 cites W2064481595 @default.
• W2943216063 cites W2071408476 @default.
• W2943216063 cites W2072081644 @default.
• W2943216063 cites W2072389038 @default.
• W2943216063 cites W2073957730 @default.
• W2943216063 cites W2074956039 @default.
• W2943216063 cites W2078684195 @default.
• W2943216063 cites W2081295656 @default.
• W2943216063 cites W2086366928 @default.
• W2943216063 cites W2087762803 @default.
• W2943216063 cites W2092148372 @default.
• W2943216063 cites W2096463314 @default.
• W2943216063 cites W2097637842 @default.
• W2943216063 cites W2103191975 @default.
• W2943216063 cites W2125091419 @default.
• W2943216063 cites W2134465607 @default.
• W2943216063 cites W2144961564 @default.
• W2943216063 cites W2148647617 @default.
• W2943216063 cites W2157849075 @default.
• W2943216063 cites W2158334050 @default.
• W2943216063 cites W2162477954 @default.
• W2943216063 cites W2169145189 @default.
• W2943216063 cites W2171423639 @default.
• W2943216063 cites W2210030555 @default.
• W2943216063 cites W2219199948 @default.
• W2943216063 cites W2254998737 @default.
• W2943216063 cites W2521286923 @default.
• W2943216063 cites W2535708619 @default.
• W2943216063 cites W2546546593 @default.
• W2943216063 cites W2596238217 @default.
• W2943216063 cites W2596390648 @default.
• W2943216063 cites W2605190485 @default.
• W2943216063 cites W2766119949 @default.
• W2943216063 cites W2769614175 @default.
• W2943216063 cites W2794998024 @default.
• W2943216063 cites W2800451343 @default.
• W2943216063 cites W2884929115 @default.
• W2943216063 cites W2937378912 @default.
• W2943216063 cites W4214940459 @default.
• W2943216063 cites W4247905931 @default.
• W2943216063 cites W4256356293 @default.
• W2943216063 doi "https://doi.org/10.1080/15376516.2019.1611981" @default.
• W2943216063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31050326" @default.
• W2943216063 hasPublicationYear "2019" @default.
• W2943216063 type Work @default.
• W2943216063 sameAs 2943216063 @default.
• W2943216063 citedByCount "5" @default.
• W2943216063 countsByYear W29432160632019 @default.
• W2943216063 countsByYear W29432160632020 @default.
• W2943216063 countsByYear W29432160632021 @default.
• W2943216063 countsByYear W29432160632022 @default.
• W2943216063 countsByYear W29432160632023 @default.
• W2943216063 crossrefType "journal-article" @default.
• W2943216063 hasAuthorship W2943216063A5009972348 @default.
• W2943216063 hasAuthorship W2943216063A5011471622 @default.
• W2943216063 hasAuthorship W2943216063A5014590960 @default.
• W2943216063 hasAuthorship W2943216063A5024906356 @default.
• W2943216063 hasAuthorship W2943216063A5029395581 @default.
• W2943216063 hasAuthorship W2943216063A5040573905 @default.
• W2943216063 hasAuthorship W2943216063A5051619050 @default.
• W2943216063 hasBestOaLocation W29432160632 @default.

• next