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- W2943220037 abstract "Crescent formation is rare in primary membranous nephropathy (MN). Anti-phospholipase A2 receptor (PLA2R) antibodies are detectable in these patients. The mechanism and treatments are unknown.A 72-year-old female patient who presented with nephrotic syndrome, hematuria, and rapidly progressive kidney dysfunction.Kidney biopsy was performed and the diagnosis was MN in combination with crescentic glomerulonephritis. Circulating anti-PLA2R IgG3 and IgG4 were detected of high level.The patient received plasma exchange and rituximab besides corticosteroids.The patient achieved complete remission of proteinuria and recovery of kidney function after the clearance of anti-PLA2R antibodies.This case suggests a pathogenic role of anti-PLA2R antibodies in the mechanism of crescent formation in MN, which may need intensive therapy to eliminate the antibodies quickly." @default.
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- W2943220037 date "2019-05-01" @default.
- W2943220037 modified "2023-09-25" @default.
- W2943220037 title "Plasma exchange and rituximab treatments in primary membranous nephropathy combined with crescentic glomerulonephritis" @default.
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- W2943220037 doi "https://doi.org/10.1097/md.0000000000015303" @default.
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