FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943224996> ?p ?o ?g. }

• W2943224996 endingPage "2125" @default.
• W2943224996 startingPage "2118" @default.
• W2943224996 abstract "Abstract Background and Aim Anti‐tumor necrosis factor (TNF) agents, such as infliximab (IFX), have been increasingly used to induce and maintain disease remission in patients with Crohn's disease (CD). Despite a considerable non‐response rate, little is known about the genetic predictors of response to anti‐TNF therapy in CD. Our aim in this study was to investigate the genetic factors associated with response to anti‐TNF therapy in patients with CD. Methods We performed a two‐stage genome‐wide association study (GWAS) to identify loci influencing the response to IFX among Korean patients with CD, comprising 42 good responders with mucosal healing and 70 non‐responders. The achievement of mucosal healing was assessed by endoscopy and imaging. The functional significance of TRAP1 (TNF receptor associated protein 1) was examined using dextran sodium sulfate‐induced colitis model in TRAP1 transgenic mice. Results The GWAS identified rs2158962, an intronic single nucleotide polymorphism (SNP) of TRAP1 , significantly associated with mucosal healing (odds ratio = 4.94; P combined = 1.35 × 10 −7 ). In the dextran sodium sulfate‐induced acute colitis, TRAP1 transgenic mice showed a better response to IFX than the wild‐type mice. Conclusions The TRAP1 gene is associated with mucosal healing in CD patients following IFX therapy. Identifying the genetic predictors of mucosal healing to anti‐TNF therapy can prevent patients from exposure to ineffective therapies." @default.
• W2943224996 created "2019-05-09" @default.
• W2943224996 creator A5008245269 @default.
• W2943224996 creator A5009385328 @default.
• W2943224996 creator A5014538081 @default.
• W2943224996 creator A5022998619 @default.
• W2943224996 creator A5034032304 @default.
• W2943224996 creator A5035282947 @default.
• W2943224996 creator A5036413144 @default.
• W2943224996 creator A5042945224 @default.
• W2943224996 creator A5048959749 @default.
• W2943224996 creator A5050440543 @default.
• W2943224996 creator A5070590963 @default.
• W2943224996 creator A5071323991 @default.
• W2943224996 creator A5075684970 @default.
• W2943224996 creator A5075907448 @default.
• W2943224996 creator A5076065674 @default.
• W2943224996 creator A5082915927 @default.
• W2943224996 creator A5090695918 @default.
• W2943224996 date "2019-06-18" @default.
• W2943224996 modified "2023-10-18" @default.
• W2943224996 title "Association of <i>TRAP1</i> with infliximab‐induced mucosal healing in Crohn's disease" @default.
• W2943224996 cites W1982280779 @default.
• W2943224996 cites W1991081070 @default.
• W2943224996 cites W2007721802 @default.
• W2943224996 cites W2026437676 @default.
• W2943224996 cites W2036394941 @default.
• W2943224996 cites W2065637841 @default.
• W2943224996 cites W2070315801 @default.
• W2943224996 cites W2105311242 @default.
• W2943224996 cites W2127242372 @default.
• W2943224996 cites W2134442010 @default.
• W2943224996 cites W2149170290 @default.
• W2943224996 cites W2168370388 @default.
• W2943224996 cites W2171341132 @default.
• W2943224996 cites W2188248802 @default.
• W2943224996 cites W2295344728 @default.
• W2943224996 cites W2321413928 @default.
• W2943224996 cites W2462268515 @default.
• W2943224996 cites W2509592131 @default.
• W2943224996 cites W2511448696 @default.
• W2943224996 cites W2522038806 @default.
• W2943224996 cites W2555614465 @default.
• W2943224996 cites W2564717375 @default.
• W2943224996 cites W2603218564 @default.
• W2943224996 cites W2755548020 @default.
• W2943224996 cites W2795730971 @default.
• W2943224996 doi "https://doi.org/10.1111/jgh.14696" @default.
• W2943224996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31039275" @default.
• W2943224996 hasPublicationYear "2019" @default.
• W2943224996 type Work @default.
• W2943224996 sameAs 2943224996 @default.
• W2943224996 citedByCount "5" @default.
• W2943224996 countsByYear W29432249962021 @default.
• W2943224996 countsByYear W29432249962022 @default.
• W2943224996 crossrefType "journal-article" @default.
• W2943224996 hasAuthorship W2943224996A5008245269 @default.
• W2943224996 hasAuthorship W2943224996A5009385328 @default.
• W2943224996 hasAuthorship W2943224996A5014538081 @default.
• W2943224996 hasAuthorship W2943224996A5022998619 @default.
• W2943224996 hasAuthorship W2943224996A5034032304 @default.
• W2943224996 hasAuthorship W2943224996A5035282947 @default.
• W2943224996 hasAuthorship W2943224996A5036413144 @default.
• W2943224996 hasAuthorship W2943224996A5042945224 @default.
• W2943224996 hasAuthorship W2943224996A5048959749 @default.
• W2943224996 hasAuthorship W2943224996A5050440543 @default.
• W2943224996 hasAuthorship W2943224996A5070590963 @default.
• W2943224996 hasAuthorship W2943224996A5071323991 @default.
• W2943224996 hasAuthorship W2943224996A5075684970 @default.
• W2943224996 hasAuthorship W2943224996A5075907448 @default.
• W2943224996 hasAuthorship W2943224996A5076065674 @default.
• W2943224996 hasAuthorship W2943224996A5082915927 @default.
• W2943224996 hasAuthorship W2943224996A5090695918 @default.
• W2943224996 hasConcept C104317684 @default.
• W2943224996 hasConcept C106208931 @default.
• W2943224996 hasConcept C126322002 @default.
• W2943224996 hasConcept C135763542 @default.
• W2943224996 hasConcept C139275648 @default.
• W2943224996 hasConcept C153209595 @default.
• W2943224996 hasConcept C156957248 @default.
• W2943224996 hasConcept C17991360 @default.
• W2943224996 hasConcept C185592680 @default.
• W2943224996 hasConcept C203014093 @default.
• W2943224996 hasConcept C2776694085 @default.
• W2943224996 hasConcept C2777138892 @default.
• W2943224996 hasConcept C2778260677 @default.
• W2943224996 hasConcept C2778283404 @default.
• W2943224996 hasConcept C2779134260 @default.
• W2943224996 hasConcept C2779280984 @default.
• W2943224996 hasConcept C2780479503 @default.
• W2943224996 hasConcept C55493867 @default.
• W2943224996 hasConcept C71924100 @default.
• W2943224996 hasConcept C90924648 @default.
• W2943224996 hasConceptScore W2943224996C104317684 @default.
• W2943224996 hasConceptScore W2943224996C106208931 @default.
• W2943224996 hasConceptScore W2943224996C126322002 @default.
• W2943224996 hasConceptScore W2943224996C135763542 @default.
• W2943224996 hasConceptScore W2943224996C139275648 @default.

• next