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- W2943225858 endingPage "485" @default.
- W2943225858 startingPage "467" @default.
- W2943225858 abstract "Background: Kinases are key modulators in regulating diverse range of cellular activities and are an essential part of the protein-protein interactome. Understanding the interaction of kinases with different substrates and other proteins is vital to decode the cell signaling machinery as well as causative mechanism for disease onset and progression. Objective: The objective of this review is to present all studies on the structure and function of few important kinases and highlight the protein-protein interaction (PPI) mechanism of kinases and the kinase specific interactome databases and how such studies could be utilized to develop anticancer drugs. Methods: The article is a review of the detailed description of the various domains in kinases that are involved in protein-protein interactions and specific inhibitors developed targeting these PPI domains. Results: The review has surfaced in depth the interacting domains in key kinases and their features and the roles of PPI in the human kinome and the various signaling cascades that are involved in certain types of cancer. Conclusion: The insight availed into the mechanism of existing peptide inhibitors and peptidomimetics against kinases will pave way for the design and generation of domain specific peptide inhibitors with better productivity and efficiency and the various software and servers available can be of great use for the identification and analysis of protein-protein interactions." @default.
- W2943225858 created "2019-05-09" @default.
- W2943225858 creator A5001831334 @default.
- W2943225858 creator A5004713122 @default.
- W2943225858 creator A5038683030 @default.
- W2943225858 date "2019-05-02" @default.
- W2943225858 modified "2023-10-02" @default.
- W2943225858 title "Targeting Kinase Interaction Networks: A New Paradigm in PPI Based Design of Kinase Inhibitors" @default.
- W2943225858 cites W11476301 @default.
- W2943225858 cites W1484094963 @default.
- W2943225858 cites W1532265037 @default.
- W2943225858 cites W1561041814 @default.
- W2943225858 cites W1571007526 @default.
- W2943225858 cites W1572174728 @default.
- W2943225858 cites W1608710587 @default.
- W2943225858 cites W1636793459 @default.
- W2943225858 cites W1685593605 @default.
- W2943225858 cites W1748445510 @default.
- W2943225858 cites W1886963552 @default.
- W2943225858 cites W1944929196 @default.
- W2943225858 cites W1962270087 @default.
- W2943225858 cites W1964194886 @default.
- W2943225858 cites W1964396270 @default.
- W2943225858 cites W1965379872 @default.
- W2943225858 cites W1966949462 @default.
- W2943225858 cites W1969259665 @default.
- W2943225858 cites W1969345506 @default.
- W2943225858 cites W1970706880 @default.
- W2943225858 cites W1972483153 @default.
- W2943225858 cites W1973596168 @default.
- W2943225858 cites W1979032223 @default.
- W2943225858 cites W1979636421 @default.
- W2943225858 cites W1981720385 @default.
- W2943225858 cites W1982078113 @default.
- W2943225858 cites W1982849870 @default.
- W2943225858 cites W1983072212 @default.
- W2943225858 cites W1983398917 @default.
- W2943225858 cites W1986308149 @default.
- W2943225858 cites W1986535773 @default.
- W2943225858 cites W1987007903 @default.
- W2943225858 cites W1990165731 @default.
- W2943225858 cites W1990868866 @default.
- W2943225858 cites W1991531834 @default.
- W2943225858 cites W1994362040 @default.
- W2943225858 cites W1996931202 @default.
- W2943225858 cites W1997759534 @default.
- W2943225858 cites W1997800445 @default.
- W2943225858 cites W1998618130 @default.
- W2943225858 cites W1999614615 @default.
- W2943225858 cites W1999868376 @default.
- W2943225858 cites W2000037457 @default.
- W2943225858 cites W2000192731 @default.
- W2943225858 cites W2000383223 @default.
- W2943225858 cites W2000596607 @default.
- W2943225858 cites W2001386734 @default.
- W2943225858 cites W2001443225 @default.
- W2943225858 cites W2003859016 @default.
- W2943225858 cites W2003931473 @default.
- W2943225858 cites W2005053674 @default.
- W2943225858 cites W2005374323 @default.
- W2943225858 cites W2007114641 @default.
- W2943225858 cites W2007683100 @default.
- W2943225858 cites W2007698657 @default.
- W2943225858 cites W2007832743 @default.
- W2943225858 cites W2007837288 @default.
- W2943225858 cites W2008173042 @default.
- W2943225858 cites W2008186410 @default.
- W2943225858 cites W2010492647 @default.
- W2943225858 cites W2011355386 @default.
- W2943225858 cites W2011659866 @default.
- W2943225858 cites W2012022940 @default.
- W2943225858 cites W2013253457 @default.
- W2943225858 cites W2015717646 @default.
- W2943225858 cites W2019127386 @default.
- W2943225858 cites W2019691413 @default.
- W2943225858 cites W2024915133 @default.
- W2943225858 cites W2025140437 @default.
- W2943225858 cites W2026004604 @default.
- W2943225858 cites W2028069947 @default.
- W2943225858 cites W2028867134 @default.
- W2943225858 cites W2029080338 @default.
- W2943225858 cites W2029709883 @default.
- W2943225858 cites W2030205108 @default.
- W2943225858 cites W2030352395 @default.
- W2943225858 cites W2031203111 @default.
- W2943225858 cites W2031772330 @default.
- W2943225858 cites W2032975373 @default.
- W2943225858 cites W2033152875 @default.
- W2943225858 cites W2035503835 @default.
- W2943225858 cites W2035805526 @default.
- W2943225858 cites W2039201738 @default.
- W2943225858 cites W2041329507 @default.
- W2943225858 cites W2045838144 @default.
- W2943225858 cites W2046845314 @default.
- W2943225858 cites W2047628330 @default.
- W2943225858 cites W2048633418 @default.
- W2943225858 cites W2049480511 @default.
- W2943225858 cites W2050779639 @default.