FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943244258> ?p ?o ?g. }

• W2943244258 endingPage "e0216095" @default.
• W2943244258 startingPage "e0216095" @default.
• W2943244258 abstract "Trastuzumab and pertuzumab are monoclonal antibodies that bind to distinct subdomains of the extracellular domain of human epidermal growth factor receptor 2 (HER2). Adding these monoclonal antibodies to the treatment regimen of HER2-positive breast cancer has changed the paradigm for treatment in that form of cancer. Synergistic activity has been observed with the combination of these two antibodies leading to hypotheses regarding the mechanism(s) and to the development of bispecific antibodies to maximize the clinical effect further. Although the individual crystal structures of HER2-trastuzumab and HER2-pertuzumab revealed the distinct binding sites and provided the structural basis for their anti-tumor activities, detailed structural information on the HER2-trastuzumab-pertuzumab complex has been elusive. Here we present the cryo-EM structure of HER2-trastuzumab-pertuzumab at 4.36 Å resolution. Comparison with the binary complexes reveals no cooperative interaction between trastuzumab and pertuzumab, and provides key insights into the design of novel, high-avidity bispecific molecules with potentially greater clinical efficacy." @default.
• W2943244258 created "2019-05-09" @default.
• W2943244258 creator A5025607826 @default.
• W2943244258 creator A5064618283 @default.
• W2943244258 creator A5066935433 @default.
• W2943244258 creator A5070412927 @default.
• W2943244258 creator A5091908601 @default.
• W2943244258 date "2019-05-01" @default.
• W2943244258 modified "2023-10-15" @default.
• W2943244258 title "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex" @default.
• W2943244258 cites W1980538880 @default.
• W2943244258 cites W1989078916 @default.
• W2943244258 cites W1993639035 @default.
• W2943244258 cites W2017693082 @default.
• W2943244258 cites W2024651005 @default.
• W2943244258 cites W2040142253 @default.
• W2943244258 cites W2048414431 @default.
• W2943244258 cites W2078454159 @default.
• W2943244258 cites W2086812659 @default.
• W2943244258 cites W2101299592 @default.
• W2943244258 cites W2104239861 @default.
• W2943244258 cites W2110635076 @default.
• W2943244258 cites W2120631765 @default.
• W2943244258 cites W2124026197 @default.
• W2943244258 cites W2132629607 @default.
• W2943244258 cites W2139135964 @default.
• W2943244258 cites W2148941629 @default.
• W2943244258 cites W2154714625 @default.
• W2943244258 cites W2161708183 @default.
• W2943244258 cites W2165003903 @default.
• W2943244258 cites W2167121370 @default.
• W2943244258 cites W2169560977 @default.
• W2943244258 cites W2265060724 @default.
• W2943244258 cites W2322951142 @default.
• W2943244258 cites W2427293830 @default.
• W2943244258 cites W2592091368 @default.
• W2943244258 cites W2610978375 @default.
• W2943244258 cites W2786390877 @default.
• W2943244258 cites W2791354025 @default.
• W2943244258 cites W2886978921 @default.
• W2943244258 cites W2891579961 @default.
• W2943244258 cites W2953320394 @default.
• W2943244258 doi "https://doi.org/10.1371/journal.pone.0216095" @default.
• W2943244258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6493747" @default.
• W2943244258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31042744" @default.
• W2943244258 hasPublicationYear "2019" @default.
• W2943244258 type Work @default.
• W2943244258 sameAs 2943244258 @default.
• W2943244258 citedByCount "23" @default.
• W2943244258 countsByYear W29432442582019 @default.
• W2943244258 countsByYear W29432442582020 @default.
• W2943244258 countsByYear W29432442582021 @default.
• W2943244258 countsByYear W29432442582022 @default.
• W2943244258 countsByYear W29432442582023 @default.
• W2943244258 crossrefType "journal-article" @default.
• W2943244258 hasAuthorship W2943244258A5025607826 @default.
• W2943244258 hasAuthorship W2943244258A5064618283 @default.
• W2943244258 hasAuthorship W2943244258A5066935433 @default.
• W2943244258 hasAuthorship W2943244258A5070412927 @default.
• W2943244258 hasAuthorship W2943244258A5091908601 @default.
• W2943244258 hasBestOaLocation W29432442581 @default.
• W2943244258 hasConcept C121608353 @default.
• W2943244258 hasConcept C159654299 @default.
• W2943244258 hasConcept C179223381 @default.
• W2943244258 hasConcept C185592680 @default.
• W2943244258 hasConcept C203014093 @default.
• W2943244258 hasConcept C2779413316 @default.
• W2943244258 hasConcept C2779786085 @default.
• W2943244258 hasConcept C2781164504 @default.
• W2943244258 hasConcept C530470458 @default.
• W2943244258 hasConcept C542903549 @default.
• W2943244258 hasConcept C54355233 @default.
• W2943244258 hasConcept C70721500 @default.
• W2943244258 hasConcept C86803240 @default.
• W2943244258 hasConceptScore W2943244258C121608353 @default.
• W2943244258 hasConceptScore W2943244258C159654299 @default.
• W2943244258 hasConceptScore W2943244258C179223381 @default.
• W2943244258 hasConceptScore W2943244258C185592680 @default.
• W2943244258 hasConceptScore W2943244258C203014093 @default.
• W2943244258 hasConceptScore W2943244258C2779413316 @default.
• W2943244258 hasConceptScore W2943244258C2779786085 @default.
• W2943244258 hasConceptScore W2943244258C2781164504 @default.
• W2943244258 hasConceptScore W2943244258C530470458 @default.
• W2943244258 hasConceptScore W2943244258C542903549 @default.
• W2943244258 hasConceptScore W2943244258C54355233 @default.
• W2943244258 hasConceptScore W2943244258C70721500 @default.
• W2943244258 hasConceptScore W2943244258C86803240 @default.
• W2943244258 hasIssue "5" @default.
• W2943244258 hasLocation W29432442581 @default.
• W2943244258 hasLocation W29432442582 @default.
• W2943244258 hasLocation W29432442583 @default.
• W2943244258 hasLocation W29432442584 @default.
• W2943244258 hasLocation W29432442585 @default.
• W2943244258 hasOpenAccess W2943244258 @default.
• W2943244258 hasPrimaryLocation W29432442581 @default.
• W2943244258 hasRelatedWork W2042242992 @default.
• W2943244258 hasRelatedWork W2767034692 @default.
• W2943244258 hasRelatedWork W2919727639 @default.

• next