FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943251911> ?p ?o ?g. }

• W2943251911 endingPage "3295" @default.
• W2943251911 startingPage "3283" @default.
• W2943251911 abstract "Solid lipid nanoparticle induced apoptosis of macrophages via a mitochondrial-dependent pathway in vitro and in vivo Wan-Li Liang,1 Lan Xiao,2 Hong-Wei Gu,1 Xiao-Jun Li,1 Yu-Sang Li,1 Wei Kevin Zhang,1 He-Bin Tang11School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People’s Republic of China; 2Department of Traditional Chinese Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, People’s Republic of ChinaBackground and aims: Lipid nanoparticles (LNs) are widely applied in drug delivery systems because they can incorporate and stabilize lipophilic and hydrophilic molecules. LNs are generally considered quite safe and convenient for in vivo applications. However, we previously observed that certain types of LNs could cause a loss of Kupffer cells, a kind of resident macrophage in the liver. As a result, we investigated the details of this phenomenon.Methods: MTT assay, Annexin-V-FITC/PI double staining, JC-1 staining, flow cytometry, Western blot and transmission electron microscopy were used in cell-based experiments. Additionally, serum biochemical analyses, H&E staining and immunofluorescence staining were performed to detect the acute and chronic changes of tissue structure and the number of Kupffer cells in mouse liver tissue samples.Results: Application of LN depolarized and swelled the mitochondria of Raw264.7 cells, and disrupted the balance of Bax/Bcl-2. This led to cleavage and activation of caspase-3 and PARP, and then induced apoptosis of Raw264.7 cells. In addition, either acute or chronic applications of LN were sufficient to disrupt the structure of the hepatic portal vein and reduce the number of Kupffer cells in mice.Conclusions: LNs could induce apoptosis of macrophages through a mitochondrial-dependent pathway.Keywords: Lipidic nanocarrier, cell death, macrophages in liver, Bax/Bcl-2, Caspase-3" @default.
• W2943251911 created "2019-05-09" @default.
• W2943251911 creator A5001188214 @default.
• W2943251911 creator A5012094328 @default.
• W2943251911 creator A5012186139 @default.
• W2943251911 creator A5022551587 @default.
• W2943251911 creator A5059417727 @default.
• W2943251911 creator A5066940954 @default.
• W2943251911 creator A5078650604 @default.
• W2943251911 date "2019-05-01" @default.
• W2943251911 modified "2023-10-16" @default.
• W2943251911 title "<p>Solid lipid nanoparticle induced apoptosis of macrophages via a mitochondrial-dependent pathway in vitro and in vivo</p>" @default.
• W2943251911 cites W1490817952 @default.
• W2943251911 cites W1968345488 @default.
• W2943251911 cites W1977143275 @default.
• W2943251911 cites W1995156576 @default.
• W2943251911 cites W1995749979 @default.
• W2943251911 cites W2010908849 @default.
• W2943251911 cites W2011476580 @default.
• W2943251911 cites W2016190851 @default.
• W2943251911 cites W2031381742 @default.
• W2943251911 cites W2054472394 @default.
• W2943251911 cites W2066936530 @default.
• W2943251911 cites W2069220094 @default.
• W2943251911 cites W2073711993 @default.
• W2943251911 cites W2085604012 @default.
• W2943251911 cites W2109448576 @default.
• W2943251911 cites W2112368754 @default.
• W2943251911 cites W2136654228 @default.
• W2943251911 cites W2138944326 @default.
• W2943251911 cites W2165089770 @default.
• W2943251911 cites W2249755146 @default.
• W2943251911 cites W2530014101 @default.
• W2943251911 cites W2564076115 @default.
• W2943251911 cites W2769418059 @default.
• W2943251911 cites W2804846127 @default.
• W2943251911 doi "https://doi.org/10.2147/ijn.s200395" @default.
• W2943251911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6511261" @default.
• W2943251911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31123400" @default.
• W2943251911 hasPublicationYear "2019" @default.
• W2943251911 type Work @default.
• W2943251911 sameAs 2943251911 @default.
• W2943251911 citedByCount "13" @default.
• W2943251911 countsByYear W29432519112020 @default.
• W2943251911 countsByYear W29432519112021 @default.
• W2943251911 countsByYear W29432519112022 @default.
• W2943251911 countsByYear W29432519112023 @default.
• W2943251911 crossrefType "journal-article" @default.
• W2943251911 hasAuthorship W2943251911A5001188214 @default.
• W2943251911 hasAuthorship W2943251911A5012094328 @default.
• W2943251911 hasAuthorship W2943251911A5012186139 @default.
• W2943251911 hasAuthorship W2943251911A5022551587 @default.
• W2943251911 hasAuthorship W2943251911A5059417727 @default.
• W2943251911 hasAuthorship W2943251911A5066940954 @default.
• W2943251911 hasAuthorship W2943251911A5078650604 @default.
• W2943251911 hasBestOaLocation W29432519111 @default.
• W2943251911 hasConcept C104317684 @default.
• W2943251911 hasConcept C142724271 @default.
• W2943251911 hasConcept C150903083 @default.
• W2943251911 hasConcept C153911025 @default.
• W2943251911 hasConcept C185592680 @default.
• W2943251911 hasConcept C190283241 @default.
• W2943251911 hasConcept C202751555 @default.
• W2943251911 hasConcept C207001950 @default.
• W2943251911 hasConcept C2776415932 @default.
• W2943251911 hasConcept C553184892 @default.
• W2943251911 hasConcept C55493867 @default.
• W2943251911 hasConcept C71924100 @default.
• W2943251911 hasConcept C74864618 @default.
• W2943251911 hasConcept C86803240 @default.
• W2943251911 hasConcept C88634738 @default.
• W2943251911 hasConcept C95444343 @default.
• W2943251911 hasConceptScore W2943251911C104317684 @default.
• W2943251911 hasConceptScore W2943251911C142724271 @default.
• W2943251911 hasConceptScore W2943251911C150903083 @default.
• W2943251911 hasConceptScore W2943251911C153911025 @default.
• W2943251911 hasConceptScore W2943251911C185592680 @default.
• W2943251911 hasConceptScore W2943251911C190283241 @default.
• W2943251911 hasConceptScore W2943251911C202751555 @default.
• W2943251911 hasConceptScore W2943251911C207001950 @default.
• W2943251911 hasConceptScore W2943251911C2776415932 @default.
• W2943251911 hasConceptScore W2943251911C553184892 @default.
• W2943251911 hasConceptScore W2943251911C55493867 @default.
• W2943251911 hasConceptScore W2943251911C71924100 @default.
• W2943251911 hasConceptScore W2943251911C74864618 @default.
• W2943251911 hasConceptScore W2943251911C86803240 @default.
• W2943251911 hasConceptScore W2943251911C88634738 @default.
• W2943251911 hasConceptScore W2943251911C95444343 @default.
• W2943251911 hasLocation W29432519111 @default.
• W2943251911 hasLocation W29432519112 @default.
• W2943251911 hasLocation W29432519113 @default.
• W2943251911 hasLocation W29432519114 @default.
• W2943251911 hasOpenAccess W2943251911 @default.
• W2943251911 hasPrimaryLocation W29432519111 @default.
• W2943251911 hasRelatedWork W2359728754 @default.
• W2943251911 hasRelatedWork W2365320098 @default.
• W2943251911 hasRelatedWork W2368209815 @default.
• W2943251911 hasRelatedWork W2372156354 @default.

• next