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• W2943331827 abstract "Neuronal apoptosis is the main pathological feature of spinal cord injury ( SCI ), while autophagy contributes to ameliorating neuronal damage via inhibition of apoptosis. Here, we investigated the role of tectonic family member 2 ( TCTN 2) long non‐coding RNA on apoptosis and autophagy in SCI . TCTN 2 was down‐regulated in the spinal cord tissues of a rat model of SCI and in oxygen–glucose deprivation‐induced hypoxic SY ‐ SH ‐5Y cells, while microRNA‐216b (miR‐216b) was up‐regulated. Overexpression of TCTN 2 reduced neuron apoptosis by inducing autophagy, and TCTN 2 was observed to negatively regulate miR‐216b. Furthermore, TCTN 2 promoted autophagy to repress apoptosis through the miR‐216b–Beclin‐1 pathway, and overexpression of TCTN 2 improved neurological function in the SCI rat model. In summary, our data suggest that TCTN 2 enhances autophagy by targeting the miR‐216b–Beclin‐1 pathway, thereby ameliorating neuronal apoptosis and relieving spinal cord injury." @default.
• W2943331827 created "2019-05-09" @default.
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• W2943331827 date "2019-06-04" @default.
• W2943331827 modified "2023-10-13" @default.
• W2943331827 title "Overexpression of lnc<scp>RNA TCTN</scp>2 protects neurons from apoptosis by enhancing cell autophagy in spinal cord injury" @default.
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• W2943331827 doi "https://doi.org/10.1002/2211-5463.12651" @default.
• W2943331827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6609579" @default.
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