FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943373913> ?p ?o ?g. }

• W2943373913 endingPage "403" @default.
• W2943373913 startingPage "403" @default.
• W2943373913 abstract "Polyamines are small positively-charged molecules abundant in eukaryotic cells that are crucial to RNA virus replication. In eukaryotic cells, polyamines facilitate processes such as transcription, translation, and DNA replication, and viruses similarly rely on polyamines to facilitate transcription and translation. Whether polyamines function at additional stages in viral replication remains poorly understood. Picornaviruses, including Coxsackievirus B3 (CVB3), are sensitive to polyamine depletion both in vitro and in vivo; however, precisely how polyamine function in picornavirus infection has not been described. Here, we describe CVB3 mutants that arise with passage in polyamine-depleted conditions. We observe mutations in the 2A and 3C proteases, and we find that these mutant proteases confer resistance to polyamine depletion. Using a split luciferase reporter system to measure protease activity, we determined that polyamines facilitate viral protease activity. We further observe that the 2A and 3C protease mutations enhance reporter protease activity in polyamine-depleted conditions. Finally, we find that these mutations promote cleavage of cellular eIF4G during infection of polyamine-depleted cells. In sum, our results suggest that polyamines are crucial to protease function during picornavirus infection. Further, these data highlight viral proteases as potential antiviral targets and highlight how CVB3 may overcome polyamine-depleting antiviral therapies." @default.
• W2943373913 created "2019-05-09" @default.
• W2943373913 creator A5006801176 @default.
• W2943373913 creator A5041261073 @default.
• W2943373913 creator A5062592298 @default.
• W2943373913 creator A5068144611 @default.
• W2943373913 date "2019-04-30" @default.
• W2943373913 modified "2023-10-01" @default.
• W2943373913 title "Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity" @default.
• W2943373913 cites W1578870099 @default.
• W2943373913 cites W1614098183 @default.
• W2943373913 cites W1978366437 @default.
• W2943373913 cites W1997720529 @default.
• W2943373913 cites W2004242355 @default.
• W2943373913 cites W2016715834 @default.
• W2943373913 cites W2023638303 @default.
• W2943373913 cites W2028953339 @default.
• W2943373913 cites W2044006050 @default.
• W2943373913 cites W2053587308 @default.
• W2943373913 cites W2062965854 @default.
• W2943373913 cites W2071010158 @default.
• W2943373913 cites W2089101049 @default.
• W2943373913 cites W2099540110 @default.
• W2943373913 cites W2101725481 @default.
• W2943373913 cites W2103119842 @default.
• W2943373913 cites W2103616039 @default.
• W2943373913 cites W2109851929 @default.
• W2943373913 cites W2111197922 @default.
• W2943373913 cites W2113679073 @default.
• W2943373913 cites W2128304092 @default.
• W2943373913 cites W2144852254 @default.
• W2943373913 cites W2157942235 @default.
• W2943373913 cites W2170215368 @default.
• W2943373913 cites W2288848507 @default.
• W2943373913 cites W2326594583 @default.
• W2943373913 cites W2331151026 @default.
• W2943373913 cites W2332032105 @default.
• W2943373913 cites W2345602871 @default.
• W2943373913 cites W2414577114 @default.
• W2943373913 cites W2474533563 @default.
• W2943373913 cites W2511526235 @default.
• W2943373913 cites W2581509802 @default.
• W2943373913 cites W2617043847 @default.
• W2943373913 cites W2621124197 @default.
• W2943373913 cites W2754196436 @default.
• W2943373913 cites W2762434015 @default.
• W2943373913 cites W2770366410 @default.
• W2943373913 cites W2775140368 @default.
• W2943373913 cites W2898431520 @default.
• W2943373913 cites W66470296 @default.
• W2943373913 doi "https://doi.org/10.3390/v11050403" @default.
• W2943373913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6563312" @default.
• W2943373913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31052199" @default.
• W2943373913 hasPublicationYear "2019" @default.
• W2943373913 type Work @default.
• W2943373913 sameAs 2943373913 @default.
• W2943373913 citedByCount "20" @default.
• W2943373913 countsByYear W29433739132019 @default.
• W2943373913 countsByYear W29433739132020 @default.
• W2943373913 countsByYear W29433739132021 @default.
• W2943373913 countsByYear W29433739132022 @default.
• W2943373913 countsByYear W29433739132023 @default.
• W2943373913 crossrefType "journal-article" @default.
• W2943373913 hasAuthorship W2943373913A5006801176 @default.
• W2943373913 hasAuthorship W2943373913A5041261073 @default.
• W2943373913 hasAuthorship W2943373913A5062592298 @default.
• W2943373913 hasAuthorship W2943373913A5068144611 @default.
• W2943373913 hasBestOaLocation W29433739131 @default.
• W2943373913 hasConcept C104317684 @default.
• W2943373913 hasConcept C105580179 @default.
• W2943373913 hasConcept C138885662 @default.
• W2943373913 hasConcept C140704245 @default.
• W2943373913 hasConcept C143065580 @default.
• W2943373913 hasConcept C149364088 @default.
• W2943373913 hasConcept C153911025 @default.
• W2943373913 hasConcept C159047783 @default.
• W2943373913 hasConcept C179926584 @default.
• W2943373913 hasConcept C181199279 @default.
• W2943373913 hasConcept C182220744 @default.
• W2943373913 hasConcept C2522874641 @default.
• W2943373913 hasConcept C2776054693 @default.
• W2943373913 hasConcept C2776714187 @default.
• W2943373913 hasConcept C2778009244 @default.
• W2943373913 hasConcept C2780115381 @default.
• W2943373913 hasConcept C41895202 @default.
• W2943373913 hasConcept C55493867 @default.
• W2943373913 hasConcept C67705224 @default.
• W2943373913 hasConcept C86803240 @default.
• W2943373913 hasConcept C95444343 @default.
• W2943373913 hasConceptScore W2943373913C104317684 @default.
• W2943373913 hasConceptScore W2943373913C105580179 @default.
• W2943373913 hasConceptScore W2943373913C138885662 @default.
• W2943373913 hasConceptScore W2943373913C140704245 @default.
• W2943373913 hasConceptScore W2943373913C143065580 @default.
• W2943373913 hasConceptScore W2943373913C149364088 @default.
• W2943373913 hasConceptScore W2943373913C153911025 @default.
• W2943373913 hasConceptScore W2943373913C159047783 @default.
• W2943373913 hasConceptScore W2943373913C179926584 @default.

• next