FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943483885> ?p ?o ?g. }

• W2943483885 endingPage "406" @default.
• W2943483885 startingPage "391" @default.
• W2943483885 abstract "We leveraged a human gut-on-a-chip (Gut Chip) microdevice that enables independent control of fluid flow and mechanical deformations to explore how physical cues and morphogen gradients influence intestinal morphogenesis. Both human intestinal Caco-2 and intestinal organoid-derived primary epithelial cells formed three-dimensional (3D) villi-like microarchitecture when exposed to apical and basal fluid flow; however, 3D morphogenesis did not occur and preformed villi-like structure involuted when basal flow was ceased. When cells were cultured in static Transwells, similar morphogenesis could be induced by removing or diluting the basal medium. Computational simulations and experimental studies revealed that the establishment of a transepithelial gradient of the Wnt antagonist Dickkopf-1 and flow-induced regulation of the Frizzled-9 receptor mediate the histogenesis. Computational simulations also predicted spatial growth patterns of 3D epithelial morphology observed experimentally in the Gut Chip. A microengineered Gut Chip may be useful for studies analyzing stem cell biology and tissue development." @default.
• W2943483885 created "2019-05-09" @default.
• W2943483885 creator A5005669988 @default.
• W2943483885 creator A5019397184 @default.
• W2943483885 creator A5072690678 @default.
• W2943483885 creator A5073384154 @default.
• W2943483885 date "2019-05-01" @default.
• W2943483885 modified "2023-10-12" @default.
• W2943483885 title "Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip" @default.
• W2943483885 cites W1522165031 @default.
• W2943483885 cites W1557541313 @default.
• W2943483885 cites W1564357553 @default.
• W2943483885 cites W1965157206 @default.
• W2943483885 cites W1967558445 @default.
• W2943483885 cites W1985656429 @default.
• W2943483885 cites W1993677820 @default.
• W2943483885 cites W1996583924 @default.
• W2943483885 cites W1997114875 @default.
• W2943483885 cites W2008127822 @default.
• W2943483885 cites W2012083927 @default.
• W2943483885 cites W2012364448 @default.
• W2943483885 cites W2017060663 @default.
• W2943483885 cites W2018448892 @default.
• W2943483885 cites W2021370278 @default.
• W2943483885 cites W2023351030 @default.
• W2943483885 cites W2031198869 @default.
• W2943483885 cites W2038714514 @default.
• W2943483885 cites W2039661491 @default.
• W2943483885 cites W2047848539 @default.
• W2943483885 cites W2052581434 @default.
• W2943483885 cites W2053086049 @default.
• W2943483885 cites W2057199920 @default.
• W2943483885 cites W2062004524 @default.
• W2943483885 cites W2077966352 @default.
• W2943483885 cites W2079819294 @default.
• W2943483885 cites W2082829054 @default.
• W2943483885 cites W2084147384 @default.
• W2943483885 cites W2091605975 @default.
• W2943483885 cites W2091643574 @default.
• W2943483885 cites W2095416190 @default.
• W2943483885 cites W2114769013 @default.
• W2943483885 cites W2115108511 @default.
• W2943483885 cites W2119284420 @default.
• W2943483885 cites W2125311914 @default.
• W2943483885 cites W2127374068 @default.
• W2943483885 cites W2128683321 @default.
• W2943483885 cites W2134120361 @default.
• W2943483885 cites W2143773031 @default.
• W2943483885 cites W2152567646 @default.
• W2943483885 cites W2157010562 @default.
• W2943483885 cites W2158273369 @default.
• W2943483885 cites W2159143688 @default.
• W2943483885 cites W2160475635 @default.
• W2943483885 cites W2163569049 @default.
• W2943483885 cites W2164851115 @default.
• W2943483885 cites W2168752825 @default.
• W2943483885 cites W2214747519 @default.
• W2943483885 cites W2258083311 @default.
• W2943483885 cites W2300378039 @default.
• W2943483885 cites W2336268115 @default.
• W2943483885 cites W2346861401 @default.
• W2943483885 cites W2508798274 @default.
• W2943483885 cites W2599036809 @default.
• W2943483885 cites W2603154743 @default.
• W2943483885 cites W2761168665 @default.
• W2943483885 cites W2794369551 @default.
• W2943483885 cites W2897044614 @default.
• W2943483885 cites W2914487205 @default.
• W2943483885 doi "https://doi.org/10.1016/j.isci.2019.04.037" @default.
• W2943483885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6526295" @default.
• W2943483885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31108394" @default.
• W2943483885 hasPublicationYear "2019" @default.
• W2943483885 type Work @default.
• W2943483885 sameAs 2943483885 @default.
• W2943483885 citedByCount "110" @default.
• W2943483885 countsByYear W29434838852019 @default.
• W2943483885 countsByYear W29434838852020 @default.
• W2943483885 countsByYear W29434838852021 @default.
• W2943483885 countsByYear W29434838852022 @default.
• W2943483885 countsByYear W29434838852023 @default.
• W2943483885 crossrefType "journal-article" @default.
• W2943483885 hasAuthorship W2943483885A5005669988 @default.
• W2943483885 hasAuthorship W2943483885A5019397184 @default.
• W2943483885 hasAuthorship W2943483885A5072690678 @default.
• W2943483885 hasAuthorship W2943483885A5073384154 @default.
• W2943483885 hasBestOaLocation W29434838851 @default.
• W2943483885 hasConcept C104317684 @default.
• W2943483885 hasConcept C105702510 @default.
• W2943483885 hasConcept C137620995 @default.
• W2943483885 hasConcept C185592680 @default.
• W2943483885 hasConcept C2778386714 @default.
• W2943483885 hasConcept C31695470 @default.
• W2943483885 hasConcept C40692019 @default.
• W2943483885 hasConcept C55493867 @default.
• W2943483885 hasConcept C62478195 @default.
• W2943483885 hasConcept C86803240 @default.
• W2943483885 hasConcept C95444343 @default.
• W2943483885 hasConceptScore W2943483885C104317684 @default.

• next