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- W2943502615 abstract "Abstract Parasites of the genus Plasmodium cause human malaria. Yet nothing is known about the viruses that infect these divergent eukaryotes. We investigated the Plasmodium virome by performing a meta-transcriptomic analysis of blood samples from malaria patients infected with P. vivax, P. falciparum or P. knowlesi . This revealed a novel bi-segmented narna-like RNA virus restricted to P. vivax and named Matryoshka RNA virus 1 (MaRNAV-1) to reflect its “Russian doll” nature: a virus, infecting a parasite, infecting an animal. MaRNAV-1 was abundant in geographically diverse P. vivax from humans and mosquitoes. Notably, a related virus (MaRNAV-2) was identified in Australian birds infected with a Leucocytozoon - eukaryotic parasites that group with Plasmodium in the Apicomplexa subclass hematozoa. This is the first report of a Plasmodium virus. As well as broadening our understanding of the eukaryotic virosphere, the restriction to P. vivax may help understand P. vivax -specific biology in humans and mosquitoes." @default.
- W2943502615 created "2019-05-09" @default.
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- W2943502615 date "2019-05-01" @default.
- W2943502615 modified "2023-10-16" @default.
- W2943502615 title "Matryoshka RNA virus 1: a novel RNA virus associated with Plasmodium parasites in human malaria" @default.
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- W2943502615 doi "https://doi.org/10.1101/624403" @default.
- W2943502615 hasPublicationYear "2019" @default.
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