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• W2943535323 abstract "Nowadays, different rapid and fully automated quantitative D-Dimer assays, majority of them being latex-enhanced photometric immunoassays (LPIA), are commercially available. The main problems are that they display variable reactivity with differently sized cross-linked fibrin derivatives, as well as variable influence of fibrinogen degradation products on assay results. The aim of this study was to compare the analytical performance of four rapid and quantitative D-Dimer assays based on different methodology: one membrane-based immunofiltration assay (IFA) and three latex-enhanced photometric immunoassays (LPIA), and to find out if there is a correlation with total fibrinogen/fibrin degradation products (TDP) measured by ELISA assay. D-dimer concentrations were measured in fresh plasma samples of 40 patients with request for the determination of d-dimer, using the NycoCard D-dimer (Axis-Shield) on NycoCard READER and IL Test D-dimer (Instrumentation Laboratory) on ACL 9000. Samples were frozen for later measurement of d-dimer with the D-Dimer PLUS assay (Dade Behring) on a BCS analyzer, STA-Liatest D-DI (Diagnostica Stago) on STA Compact and for the measurement of TDP with Fibrinostika TDP (BioMerieux). The measurements included all available assay specific controls. Of the four assays performed, at least one resulted in discrepant results in 16/40 (40%) samples tested. The samples were separated into four groups according to NycoCard results: group I, 1.2 mg/L. All assays gave comparable results for samples in group IV. Majority of the results were comparable in group III, except for 4 samples that were falsely negative: 1 with STA Liatest D-DI and 3 with IL Test D-Dimer. The greatest discrepancy between results was found just above the NycoCard cut-off value (in the range of 0.3-0.6 mg/L) in 9/12 samples in group II. Between five samples with normal NycoCard D-Dimer values (group I.), we found three falsely positive results: 1 with STA Liatest D-DI and 2 with D-Dimer PLUS assay. The relationship between TDP and D-Dimer assays showed correlation coefficients (r) as follows: 0.736 for NycoCard, 0.859 for IL Test D-Dimer, 0.596 for D-Dimer PLUS and 0.867 for STA Liatest D-DI. As discrepancies in the obtained results can be due to different calibrators and different monoclonal antibodies used, the follow-up of patients should be always performed with the same assay system, until the common calibrator is available." @default.
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• W2943535323 date "2004-11-05" @default.
• W2943535323 modified "2023-09-27" @default.
• W2943535323 title "Comparative evaluation of four rapid quantitative D-dimer assays" @default.
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