Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943554224> ?p ?o ?g. }
- W2943554224 abstract "During development, neural crest (NC) cells are early precursors of several lineages including melanocytes. Along their differentiation from multipotent cells to mature melanocytes, NC cells will go through successive steps which require either proliferative or motile capacities. For example, they will undergo Epithelial to Mesenchymal Transition (EMT) in order the separate from the neural tube and migrate to their final location in the epidermis (Larribere & Utikal, 2013; Skrypek, Goossens, De Smedt, Vandamme, & Berx, 2017). The differentiated melanocytes are the cells of origin of melanoma tumors which progress through several stages such as radial growth phase, vertical growth phase, metastasis formation, and often resistance to current therapies. Interestingly, depending on the stage of the disease, melanoma tumor cells share phenotypes with NC cells (proliferative, motile, EMT). These phenotypes are tightly controlled by specific signaling pathways and transcription factors which tend to be reactivated during the onset of melanoma. In this review, we summarize first the main transcription factors which control these common phenotypes. Then, we focus on the existing strategies used to generate human neural crests. Finally we discuss how identification and regulation of neural crest-associated genes provide an additional approach to improving current melanoma targeted therapies." @default.
- W2943554224 created "2019-05-09" @default.
- W2943554224 creator A5007887862 @default.
- W2943554224 creator A5057144411 @default.
- W2943554224 date "2019-05-01" @default.
- W2943554224 modified "2023-10-16" @default.
- W2943554224 title "Stem Cell-Derived Models of Neural Crest Are Essential to Understand Melanoma Progression and Therapy Resistance" @default.
- W2943554224 cites W1525984035 @default.
- W2943554224 cites W1561427403 @default.
- W2943554224 cites W1590243782 @default.
- W2943554224 cites W1834835434 @default.
- W2943554224 cites W1933932217 @default.
- W2943554224 cites W1945938728 @default.
- W2943554224 cites W1965428318 @default.
- W2943554224 cites W1966467063 @default.
- W2943554224 cites W1966535246 @default.
- W2943554224 cites W1973569563 @default.
- W2943554224 cites W1980851632 @default.
- W2943554224 cites W1981040271 @default.
- W2943554224 cites W1981974890 @default.
- W2943554224 cites W1983318575 @default.
- W2943554224 cites W1985449670 @default.
- W2943554224 cites W1985577088 @default.
- W2943554224 cites W1985928174 @default.
- W2943554224 cites W1993909108 @default.
- W2943554224 cites W1995517904 @default.
- W2943554224 cites W1996530575 @default.
- W2943554224 cites W1996765884 @default.
- W2943554224 cites W1997889534 @default.
- W2943554224 cites W2000146676 @default.
- W2943554224 cites W2004731962 @default.
- W2943554224 cites W2008878539 @default.
- W2943554224 cites W2011024729 @default.
- W2943554224 cites W2016456453 @default.
- W2943554224 cites W2016606965 @default.
- W2943554224 cites W2017463214 @default.
- W2943554224 cites W2018433132 @default.
- W2943554224 cites W2021304700 @default.
- W2943554224 cites W2023518851 @default.
- W2943554224 cites W2032336674 @default.
- W2943554224 cites W2034879573 @default.
- W2943554224 cites W2044424175 @default.
- W2943554224 cites W2047608903 @default.
- W2943554224 cites W2048140690 @default.
- W2943554224 cites W2048350099 @default.
- W2943554224 cites W2051718122 @default.
- W2943554224 cites W2051807533 @default.
- W2943554224 cites W2052005627 @default.
- W2943554224 cites W2052623623 @default.
- W2943554224 cites W2061339803 @default.
- W2943554224 cites W2062595374 @default.
- W2943554224 cites W2063620211 @default.
- W2943554224 cites W2072206017 @default.
- W2943554224 cites W2072569544 @default.
- W2943554224 cites W2073853835 @default.
- W2943554224 cites W2076851669 @default.
- W2943554224 cites W2077320267 @default.
- W2943554224 cites W2078370873 @default.
- W2943554224 cites W2081235375 @default.
- W2943554224 cites W2082682623 @default.
- W2943554224 cites W2086943348 @default.
- W2943554224 cites W2087447340 @default.
- W2943554224 cites W2087786585 @default.
- W2943554224 cites W2091048750 @default.
- W2943554224 cites W2096387850 @default.
- W2943554224 cites W2102927263 @default.
- W2943554224 cites W2103489164 @default.
- W2943554224 cites W2106391833 @default.
- W2943554224 cites W2116978375 @default.
- W2943554224 cites W2117814548 @default.
- W2943554224 cites W2124467126 @default.
- W2943554224 cites W2126016558 @default.
- W2943554224 cites W2126774748 @default.
- W2943554224 cites W2138977668 @default.
- W2943554224 cites W2142715432 @default.
- W2943554224 cites W2146079271 @default.
- W2943554224 cites W2146212371 @default.
- W2943554224 cites W2146326641 @default.
- W2943554224 cites W2158416296 @default.
- W2943554224 cites W2159220884 @default.
- W2943554224 cites W2162497387 @default.
- W2943554224 cites W2166728527 @default.
- W2943554224 cites W2168820637 @default.
- W2943554224 cites W2176310149 @default.
- W2943554224 cites W2268569236 @default.
- W2943554224 cites W2300290254 @default.
- W2943554224 cites W2345380485 @default.
- W2943554224 cites W2412946872 @default.
- W2943554224 cites W2424133004 @default.
- W2943554224 cites W2569342357 @default.
- W2943554224 cites W2577256604 @default.
- W2943554224 cites W2594529508 @default.
- W2943554224 cites W2594998765 @default.
- W2943554224 cites W2611270905 @default.
- W2943554224 cites W2621895366 @default.
- W2943554224 cites W2713351076 @default.
- W2943554224 cites W2754995492 @default.
- W2943554224 cites W2755736417 @default.
- W2943554224 cites W2765905272 @default.
- W2943554224 cites W2769260230 @default.