FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943557932> ?p ?o ?g. }

• W2943557932 abstract "Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with cord blood DNA methylation across the genome at birth and test for persistence of associations in early and mid-childhood blood DNA. A discovery phase was conducted in Project Viva, a prospective pre-birth cohort study with external replication in an independent cohort, the Generation R Study. In Project Viva, pregnant women were recruited between 1999 and 2002 in Eastern Massachusetts, USA. In the Generation R Study, pregnant women were recruited between 2002 and 2006 in Rotterdam, the Netherlands. In Project Viva, 479 infants had data on maternal antidepressant use, anxiety, depression, and cord blood DNA methylation, 120 children had DNA methylation measured in early childhood (~ 3 years), and 460 in mid-childhood (~ 7 years). In the Generation R Study, 999 infants had data on maternal antidepressants and cord blood DNA methylation. The prenatal antidepressant prescription was obtained from medical records. At-mid pregnancy, symptoms of anxiety and depression were assessed with the Pregnancy-Related Anxiety Scale and the Edinburgh Postnatal Depression Scale in Project Viva and with the Brief Symptom Inventory in the Generation R Study. Genome-wide DNA methylation was measured using the Infinium HumanMethylation450 BeadChip in both cohorts. In Project Viva, 2.9% (14/479) pregnant women were prescribed antidepressants, 9.0% (40/445) experienced high pregnancy-related anxiety, and 8.2% (33/402) reported symptoms consistent with depression. Newborns exposed to antidepressants in pregnancy had 7.2% lower DNA methylation (95% CI, − 10.4, − 4.1; P = 1.03 × 10−8) at cg22159528 located in the gene body of ZNF575, and this association replicated in the Generation R Study (β = − 2.5%; 95% CI − 4.2, − 0.7; P = 0.006). In Project Viva, the association persisted in early (β = − 6.2%; 95% CI − 10.7, − 1.6) but not mid-childhood. We observed cohort-specific associations for maternal anxiety and depression in Project Viva that did not replicate. The ZNF575 gene is involved in transcriptional regulation but specific functions are largely unknown. Given the widespread use of antidepressants in pregnancy, as well as the effects of exposure to anxiety and depression, implications of potential fetal epigenetic programming by these risk factors and their impacts on development merit further investigation." @default.
• W2943557932 created "2019-05-09" @default.
• W2943557932 creator A5008242847 @default.
• W2943557932 creator A5012921360 @default.
• W2943557932 creator A5030667666 @default.
• W2943557932 creator A5036025037 @default.
• W2943557932 creator A5043654791 @default.
• W2943557932 creator A5044611532 @default.
• W2943557932 creator A5046263397 @default.
• W2943557932 creator A5050080111 @default.
• W2943557932 creator A5051093934 @default.
• W2943557932 creator A5054864150 @default.
• W2943557932 creator A5069636788 @default.
• W2943557932 creator A5074833807 @default.
• W2943557932 creator A5076290987 @default.
• W2943557932 creator A5077350027 @default.
• W2943557932 creator A5086120301 @default.
• W2943557932 date "2019-03-29" @default.
• W2943557932 modified "2023-10-17" @default.
• W2943557932 title "Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood" @default.
• W2943557932 cites W1788119076 @default.
• W2943557932 cites W1838663810 @default.
• W2943557932 cites W1871144505 @default.
• W2943557932 cites W1901031838 @default.
• W2943557932 cites W1975528145 @default.
• W2943557932 cites W1988643756 @default.
• W2943557932 cites W2010993240 @default.
• W2943557932 cites W2012558225 @default.
• W2943557932 cites W2016907728 @default.
• W2943557932 cites W2041445212 @default.
• W2943557932 cites W2042084261 @default.
• W2943557932 cites W2042764317 @default.
• W2943557932 cites W2056040742 @default.
• W2943557932 cites W2063638540 @default.
• W2943557932 cites W2081182312 @default.
• W2943557932 cites W2094627775 @default.
• W2943557932 cites W2099411968 @default.
• W2943557932 cites W2101870168 @default.
• W2943557932 cites W2106670153 @default.
• W2943557932 cites W2107959833 @default.
• W2943557932 cites W2110673629 @default.
• W2943557932 cites W2112296601 @default.
• W2943557932 cites W2117733693 @default.
• W2943557932 cites W2120535922 @default.
• W2943557932 cites W2120795379 @default.
• W2943557932 cites W2123929789 @default.
• W2943557932 cites W2127431419 @default.
• W2943557932 cites W2127555525 @default.
• W2943557932 cites W2127957476 @default.
• W2943557932 cites W2132747525 @default.
• W2943557932 cites W2148228932 @default.
• W2943557932 cites W2148347880 @default.
• W2943557932 cites W2149264570 @default.
• W2943557932 cites W2151396264 @default.
• W2943557932 cites W2151730966 @default.
• W2943557932 cites W2153466773 @default.
• W2943557932 cites W2153491127 @default.
• W2943557932 cites W2156460754 @default.
• W2943557932 cites W2157406479 @default.
• W2943557932 cites W2157465110 @default.
• W2943557932 cites W2161857374 @default.
• W2943557932 cites W2169353806 @default.
• W2943557932 cites W2325315748 @default.
• W2943557932 cites W2345932531 @default.
• W2943557932 cites W2511775216 @default.
• W2943557932 cites W2559791676 @default.
• W2943557932 cites W2592199299 @default.
• W2943557932 cites W2618311580 @default.
• W2943557932 cites W2751818717 @default.
• W2943557932 cites W4210761116 @default.
• W2943557932 cites W4235958520 @default.
• W2943557932 cites W4297674379 @default.
• W2943557932 doi "https://doi.org/10.1186/s13148-019-0653-x" @default.
• W2943557932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6441191" @default.
• W2943557932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30925934" @default.
• W2943557932 hasPublicationYear "2019" @default.
• W2943557932 type Work @default.
• W2943557932 sameAs 2943557932 @default.
• W2943557932 citedByCount "40" @default.
• W2943557932 countsByYear W29435579322020 @default.
• W2943557932 countsByYear W29435579322021 @default.
• W2943557932 countsByYear W29435579322022 @default.
• W2943557932 countsByYear W29435579322023 @default.
• W2943557932 crossrefType "journal-article" @default.
• W2943557932 hasAuthorship W2943557932A5008242847 @default.
• W2943557932 hasAuthorship W2943557932A5012921360 @default.
• W2943557932 hasAuthorship W2943557932A5030667666 @default.
• W2943557932 hasAuthorship W2943557932A5036025037 @default.
• W2943557932 hasAuthorship W2943557932A5043654791 @default.
• W2943557932 hasAuthorship W2943557932A5044611532 @default.
• W2943557932 hasAuthorship W2943557932A5046263397 @default.
• W2943557932 hasAuthorship W2943557932A5050080111 @default.
• W2943557932 hasAuthorship W2943557932A5051093934 @default.
• W2943557932 hasAuthorship W2943557932A5054864150 @default.
• W2943557932 hasAuthorship W2943557932A5069636788 @default.
• W2943557932 hasAuthorship W2943557932A5074833807 @default.
• W2943557932 hasAuthorship W2943557932A5076290987 @default.
• W2943557932 hasAuthorship W2943557932A5077350027 @default.
• W2943557932 hasAuthorship W2943557932A5086120301 @default.
• W2943557932 hasBestOaLocation W29435579321 @default.

• next