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- W2943624362 abstract "Obesity in the western world has reached epidemic proportions, and yet the long-term effects on brain health are not well understood. To address this, we performed transcriptional profiling of brain regions from a mouse model of western diet (WD)-induced obesity. Both the cortex and hippocampus from C57BL/6J (B6) mice fed either a WD or a control diet from 2 months of age to 12 months of age (equivalent to midlife in a human population) were profiled. Gene set enrichment analyses predicted that genes involved in myelin generation, inflammation, and cerebrovascular health were differentially expressed in brains from WD-fed compared to control diet-fed mice. White matter damage and cerebrovascular decline were evident in brains from WD-fed mice using immunofluorescence and electron microscopy. At the cellular level, the WD caused an increase in the numbers of oligodendrocytes and myeloid cells suggesting that a WD is perturbing myelin turnover. Encouragingly, cerebrovascular damage and white matter damage were prevented by exercising WD-fed mice despite mice still gaining a significant amount of weight. Collectively, these data show that chronic consumption of a WD in B6 mice causes obesity, neuroinflammation, and cerebrovascular and white matter damage, but these potentially damaging effects can be prevented by modifiable risk factors such as exercise." @default.
- W2943624362 created "2019-05-09" @default.
- W2943624362 creator A5009861219 @default.
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- W2943624362 creator A5090830119 @default.
- W2943624362 date "2019-08-01" @default.
- W2943624362 modified "2023-10-14" @default.
- W2943624362 title "Exercise prevents obesity-induced cognitive decline and white matter damage in mice" @default.
- W2943624362 cites W1540592466 @default.
- W2943624362 cites W1906793157 @default.
- W2943624362 cites W1959902108 @default.
- W2943624362 cites W1963097925 @default.
- W2943624362 cites W1965656202 @default.
- W2943624362 cites W1966017102 @default.
- W2943624362 cites W1967830289 @default.
- W2943624362 cites W1968458420 @default.
- W2943624362 cites W1980542913 @default.
- W2943624362 cites W1980679634 @default.
- W2943624362 cites W1982643425 @default.
- W2943624362 cites W1983740408 @default.
- W2943624362 cites W1985808169 @default.
- W2943624362 cites W1987192817 @default.
- W2943624362 cites W1992509114 @default.
- W2943624362 cites W1994206031 @default.
- W2943624362 cites W1998589563 @default.
- W2943624362 cites W1999132792 @default.
- W2943624362 cites W1999574084 @default.
- W2943624362 cites W2001477615 @default.
- W2943624362 cites W2001674088 @default.
- W2943624362 cites W2003318621 @default.
- W2943624362 cites W2003837387 @default.
- W2943624362 cites W2004006028 @default.
- W2943624362 cites W2007743324 @default.
- W2943624362 cites W2015620326 @default.
- W2943624362 cites W2017423317 @default.
- W2943624362 cites W2018233879 @default.
- W2943624362 cites W2022857700 @default.
- W2943624362 cites W2026397702 @default.
- W2943624362 cites W2031479105 @default.
- W2943624362 cites W2032054191 @default.
- W2943624362 cites W2033641342 @default.
- W2943624362 cites W2034275438 @default.
- W2943624362 cites W2039677191 @default.
- W2943624362 cites W2040517865 @default.
- W2943624362 cites W2040862810 @default.
- W2943624362 cites W2044614452 @default.
- W2943624362 cites W2044654272 @default.
- W2943624362 cites W2047152236 @default.
- W2943624362 cites W2048501712 @default.
- W2943624362 cites W2048674585 @default.
- W2943624362 cites W2055264753 @default.
- W2943624362 cites W2060982295 @default.
- W2943624362 cites W2064171780 @default.
- W2943624362 cites W2064395106 @default.
- W2943624362 cites W2065245791 @default.
- W2943624362 cites W2070155357 @default.
- W2943624362 cites W2070381267 @default.
- W2943624362 cites W2071881327 @default.
- W2943624362 cites W2071987414 @default.
- W2943624362 cites W2073101750 @default.
- W2943624362 cites W2080001188 @default.
- W2943624362 cites W2088101561 @default.
- W2943624362 cites W2088736158 @default.
- W2943624362 cites W2092496538 @default.
- W2943624362 cites W2094660330 @default.
- W2943624362 cites W2094831055 @default.
- W2943624362 cites W2095209569 @default.
- W2943624362 cites W2099853999 @default.
- W2943624362 cites W2100164454 @default.
- W2943624362 cites W2100809123 @default.
- W2943624362 cites W2103374433 @default.
- W2943624362 cites W2107199945 @default.
- W2943624362 cites W2108205699 @default.
- W2943624362 cites W2109290881 @default.
- W2943624362 cites W2114104545 @default.
- W2943624362 cites W2119757776 @default.
- W2943624362 cites W2121516366 @default.
- W2943624362 cites W2122328291 @default.
- W2943624362 cites W2123019462 @default.
- W2943624362 cites W2124985265 @default.
- W2943624362 cites W2126479164 @default.
- W2943624362 cites W2126693856 @default.
- W2943624362 cites W2126950194 @default.
- W2943624362 cites W2129054908 @default.
- W2943624362 cites W2129082205 @default.
- W2943624362 cites W2132513137 @default.
- W2943624362 cites W2132985113 @default.
- W2943624362 cites W2133194839 @default.
- W2943624362 cites W2136649249 @default.
- W2943624362 cites W2139530732 @default.
- W2943624362 cites W2142514276 @default.
- W2943624362 cites W2145870733 @default.
- W2943624362 cites W2148954067 @default.