FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943642248> ?p ?o ?g. }

• W2943642248 endingPage "232" @default.
• W2943642248 startingPage "223" @default.
• W2943642248 abstract "In the event of a novel influenza strain that is markedly different to the current strains circulating in humans, the population have little/no immunity and infection spreads quickly causing a global pandemic. Over the past century, there have been four major influenza pandemics: the 1918 pandemic (Spanish Flu), the 1957-58 pandemic (the Asian Flu), the 1967-68 pandemic (the Hong Kong Flu) and the 2009 pandemic (the Swine flu). To inform planning against future pandemics, this paper investigates how different is the net-present value of employing pre-purchase and responsive- purchased vaccine programmes in presence and absence of anti-viral drugs to scenarios that resemble these historic influenza pandemics. Using the existing literature and in discussions with policy decision makers in the UK, we first characterised the four past influenza pandemics by their transmissibility and infection-severity. For these combinations of parameters, we then projected the net-present value of employing pre-purchase vaccine (PPV) and responsive-purchase vaccine (RPV) programmes in presence and absence of anti-viral drugs. To differentiate between PPV and RPV policies, we changed the vaccine effectiveness value and the time to when the vaccine is first available. Our results are heat-map graphs displaying the benefits of different strategies in pandemic scenarios that resemble historic influenza pandemics. Our results suggest that immunisation with either PPV or RPV in presence of a stockpile of effective antiviral drugs, does not have positive net-present value for all of the pandemic scenarios considered. In contrast, in the absence of effective antivirals, both PPV and RPV policies have positive net-present value across all the pandemic scenarios. Moreover, in all considered circumstances, vaccination was most beneficial if started sufficiently early and covered sufficiently large number of people. When comparing the two vaccine programmes, the RPV policy allowed a longer timeframe and lower coverage to attain the same benefit as the PPV policy. Our findings suggest that responsive-purchase vaccination policy has a bigger window of positive net-present value when employed against each of the historic influenza pandemic strains but needs to be rapidly available to maximise benefit. This is important for future planning as it suggests that future preparedness policies may wish to consider utilising timely (i.e. responsive-purchased) vaccines against emerging influenza pandemics." @default.
• W2943642248 created "2019-05-09" @default.
• W2943642248 creator A5000912579 @default.
• W2943642248 creator A5033086931 @default.
• W2943642248 creator A5042672436 @default.
• W2943642248 creator A5061272028 @default.
• W2943642248 creator A5089866449 @default.
• W2943642248 creator A5090834732 @default.
• W2943642248 date "2019-11-01" @default.
• W2943642248 modified "2023-10-01" @default.
• W2943642248 title "Are we prepared for the next influenza pandemic? Lessons from modelling different preparedness policies against four pandemic scenarios" @default.
• W2943642248 cites W1964672660 @default.
• W2943642248 cites W2001848107 @default.
• W2943642248 cites W2011444608 @default.
• W2943642248 cites W2035692177 @default.
• W2943642248 cites W2039583380 @default.
• W2943642248 cites W2054987357 @default.
• W2943642248 cites W2065069831 @default.
• W2943642248 cites W2078190655 @default.
• W2943642248 cites W2082036062 @default.
• W2943642248 cites W2097158347 @default.
• W2943642248 cites W2100866656 @default.
• W2943642248 cites W2104424333 @default.
• W2943642248 cites W2110062524 @default.
• W2943642248 cites W2125761044 @default.
• W2943642248 cites W2128992161 @default.
• W2943642248 cites W2145603505 @default.
• W2943642248 cites W2155077350 @default.
• W2943642248 cites W2157725602 @default.
• W2943642248 cites W2171506177 @default.
• W2943642248 cites W2703965028 @default.
• W2943642248 cites W2768247324 @default.
• W2943642248 cites W4232540467 @default.
• W2943642248 cites W4233976476 @default.
• W2943642248 cites W4256468322 @default.
• W2943642248 cites W4292550103 @default.
• W2943642248 doi "https://doi.org/10.1016/j.jtbi.2019.05.003" @default.
• W2943642248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31059716" @default.
• W2943642248 hasPublicationYear "2019" @default.
• W2943642248 type Work @default.
• W2943642248 sameAs 2943642248 @default.
• W2943642248 citedByCount "15" @default.
• W2943642248 countsByYear W29436422482020 @default.
• W2943642248 countsByYear W29436422482021 @default.
• W2943642248 countsByYear W29436422482022 @default.
• W2943642248 crossrefType "journal-article" @default.
• W2943642248 hasAuthorship W2943642248A5000912579 @default.
• W2943642248 hasAuthorship W2943642248A5033086931 @default.
• W2943642248 hasAuthorship W2943642248A5042672436 @default.
• W2943642248 hasAuthorship W2943642248A5061272028 @default.
• W2943642248 hasAuthorship W2943642248A5089866449 @default.
• W2943642248 hasAuthorship W2943642248A5090834732 @default.
• W2943642248 hasBestOaLocation W29436422482 @default.
• W2943642248 hasConcept C142724271 @default.
• W2943642248 hasConcept C159047783 @default.
• W2943642248 hasConcept C17744445 @default.
• W2943642248 hasConcept C192805744 @default.
• W2943642248 hasConcept C199539241 @default.
• W2943642248 hasConcept C205649164 @default.
• W2943642248 hasConcept C22070199 @default.
• W2943642248 hasConcept C2777042776 @default.
• W2943642248 hasConcept C2779134260 @default.
• W2943642248 hasConcept C2780689484 @default.
• W2943642248 hasConcept C2781425195 @default.
• W2943642248 hasConcept C2908647359 @default.
• W2943642248 hasConcept C3008058167 @default.
• W2943642248 hasConcept C3018061469 @default.
• W2943642248 hasConcept C3019926118 @default.
• W2943642248 hasConcept C524204448 @default.
• W2943642248 hasConcept C71924100 @default.
• W2943642248 hasConcept C89623803 @default.
• W2943642248 hasConcept C99454951 @default.
• W2943642248 hasConceptScore W2943642248C142724271 @default.
• W2943642248 hasConceptScore W2943642248C159047783 @default.
• W2943642248 hasConceptScore W2943642248C17744445 @default.
• W2943642248 hasConceptScore W2943642248C192805744 @default.
• W2943642248 hasConceptScore W2943642248C199539241 @default.
• W2943642248 hasConceptScore W2943642248C205649164 @default.
• W2943642248 hasConceptScore W2943642248C22070199 @default.
• W2943642248 hasConceptScore W2943642248C2777042776 @default.
• W2943642248 hasConceptScore W2943642248C2779134260 @default.
• W2943642248 hasConceptScore W2943642248C2780689484 @default.
• W2943642248 hasConceptScore W2943642248C2781425195 @default.
• W2943642248 hasConceptScore W2943642248C2908647359 @default.
• W2943642248 hasConceptScore W2943642248C3008058167 @default.
• W2943642248 hasConceptScore W2943642248C3018061469 @default.
• W2943642248 hasConceptScore W2943642248C3019926118 @default.
• W2943642248 hasConceptScore W2943642248C524204448 @default.
• W2943642248 hasConceptScore W2943642248C71924100 @default.
• W2943642248 hasConceptScore W2943642248C89623803 @default.
• W2943642248 hasConceptScore W2943642248C99454951 @default.
• W2943642248 hasFunder F4320319990 @default.
• W2943642248 hasFunder F4320337544 @default.
• W2943642248 hasLocation W29436422481 @default.
• W2943642248 hasLocation W29436422482 @default.
• W2943642248 hasLocation W29436422483 @default.
• W2943642248 hasLocation W29436422484 @default.
• W2943642248 hasLocation W29436422485 @default.

• next