FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943670034> ?p ?o ?g. }

• W2943670034 abstract "Immunoglobulin E (IgE) is the treatment target of omalizumab, a monoclonal antibody indicated in the treatment of severe allergic asthma. Long-term variability of serum total IgE (sIgEtot) in asthmatics remains poorly documented. In this prospective study, sIgEtot levels were measured over 1 year at 7 time points in 41 severe asthmatics treated with high-dose of inhaled corticosteroids and long-acting β2 agonists. 33 patients were atopic based on at least one positive RAST to common aeroallergens. Patients were divided into three groups according to their baseline sIgEtot level: low (< 76 IU/mL; n = 10), intermediate (76–700 IU/mL; n = 20) or high (> 700 IU/mL; n = 11). Patients also completed the six-item Juniper Asthma Control Questionnaire (ACQ6). The sIgEtot variability and factors predictive for this variability were studied, as well as ACQ6 outcomes. The variation in sIgEtot level was mostly the consequence of between patient-variability, which represented 96%, 71% and 96% of the total variability in the low, intermediate and high sIgEtot subgroups, respectively. The residual within-patient variability was therefore limited. In 10/41 patients, sIgEtot levels increased or decreased, for at least one visit, beyond the predefined range of the subgroups to which they were assigned (< 76 IU/mL; 76–700 IU/mL; > 700 IU/mL). There was a significant but weak correlation between sIgEtot and ACQ6 score over all time points (r = 0.15, p = 0.02), but sIgEtot failed to associate with severe exacerbation. sIgEtot decreased by 3% with any additional year of age for the whole group (p = 0.01) and increased by 5% per one unit of allergen exposure score in atopic patients (p = 0.002). In severe asthmatics, limited within-patient variability of sIgEtot levels was observed over 1 year as opposed to marked between-subject variability. sIgEtot decreases with age. Variation in sIgEtot weakly associates with asthma control but not with exacerbation." @default.
• W2943670034 created "2019-05-09" @default.
• W2943670034 creator A5001199263 @default.
• W2943670034 creator A5005167055 @default.
• W2943670034 creator A5030456446 @default.
• W2943670034 creator A5031658471 @default.
• W2943670034 creator A5036601889 @default.
• W2943670034 creator A5059141841 @default.
• W2943670034 creator A5063249079 @default.
• W2943670034 creator A5064912243 @default.
• W2943670034 creator A5068493725 @default.
• W2943670034 creator A5071183245 @default.
• W2943670034 creator A5084615376 @default.
• W2943670034 date "2019-03-29" @default.
• W2943670034 modified "2023-10-04" @default.
• W2943670034 title "Variability in total serum IgE over 1 year in severe asthmatics" @default.
• W2943670034 cites W1841302417 @default.
• W2943670034 cites W1983684099 @default.
• W2943670034 cites W1985748428 @default.
• W2943670034 cites W1986204470 @default.
• W2943670034 cites W1993539182 @default.
• W2943670034 cites W2000167866 @default.
• W2943670034 cites W2015409726 @default.
• W2943670034 cites W2029587541 @default.
• W2943670034 cites W2039439214 @default.
• W2943670034 cites W2039849310 @default.
• W2943670034 cites W2064037280 @default.
• W2943670034 cites W2064296795 @default.
• W2943670034 cites W2098276532 @default.
• W2943670034 cites W2105707546 @default.
• W2943670034 cites W2120948675 @default.
• W2943670034 cites W2121954044 @default.
• W2943670034 cites W2129649074 @default.
• W2943670034 cites W2131818458 @default.
• W2943670034 cites W2154766995 @default.
• W2943670034 cites W2326847380 @default.
• W2943670034 cites W2463627988 @default.
• W2943670034 cites W2517035143 @default.
• W2943670034 cites W85225990 @default.
• W2943670034 doi "https://doi.org/10.1186/s13223-019-0331-8" @default.
• W2943670034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6441212" @default.
• W2943670034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30976287" @default.
• W2943670034 hasPublicationYear "2019" @default.
• W2943670034 type Work @default.
• W2943670034 sameAs 2943670034 @default.
• W2943670034 citedByCount "13" @default.
• W2943670034 countsByYear W29436700342020 @default.
• W2943670034 countsByYear W29436700342021 @default.
• W2943670034 countsByYear W29436700342022 @default.
• W2943670034 countsByYear W29436700342023 @default.
• W2943670034 crossrefType "journal-article" @default.
• W2943670034 hasAuthorship W2943670034A5001199263 @default.
• W2943670034 hasAuthorship W2943670034A5005167055 @default.
• W2943670034 hasAuthorship W2943670034A5030456446 @default.
• W2943670034 hasAuthorship W2943670034A5031658471 @default.
• W2943670034 hasAuthorship W2943670034A5036601889 @default.
• W2943670034 hasAuthorship W2943670034A5059141841 @default.
• W2943670034 hasAuthorship W2943670034A5063249079 @default.
• W2943670034 hasAuthorship W2943670034A5064912243 @default.
• W2943670034 hasAuthorship W2943670034A5068493725 @default.
• W2943670034 hasAuthorship W2943670034A5071183245 @default.
• W2943670034 hasAuthorship W2943670034A5084615376 @default.
• W2943670034 hasBestOaLocation W29436700341 @default.
• W2943670034 hasConcept C126322002 @default.
• W2943670034 hasConcept C141105273 @default.
• W2943670034 hasConcept C159654299 @default.
• W2943670034 hasConcept C203014093 @default.
• W2943670034 hasConcept C2776042228 @default.
• W2943670034 hasConcept C2777014857 @default.
• W2943670034 hasConcept C2778564945 @default.
• W2943670034 hasConcept C71924100 @default.
• W2943670034 hasConcept C90924648 @default.
• W2943670034 hasConceptScore W2943670034C126322002 @default.
• W2943670034 hasConceptScore W2943670034C141105273 @default.
• W2943670034 hasConceptScore W2943670034C159654299 @default.
• W2943670034 hasConceptScore W2943670034C203014093 @default.
• W2943670034 hasConceptScore W2943670034C2776042228 @default.
• W2943670034 hasConceptScore W2943670034C2777014857 @default.
• W2943670034 hasConceptScore W2943670034C2778564945 @default.
• W2943670034 hasConceptScore W2943670034C71924100 @default.
• W2943670034 hasConceptScore W2943670034C90924648 @default.
• W2943670034 hasFunder F4320332736 @default.
• W2943670034 hasIssue "1" @default.
• W2943670034 hasLocation W29436700341 @default.
• W2943670034 hasLocation W29436700342 @default.
• W2943670034 hasLocation W29436700343 @default.
• W2943670034 hasLocation W29436700344 @default.
• W2943670034 hasLocation W29436700345 @default.
• W2943670034 hasLocation W29436700346 @default.
• W2943670034 hasLocation W29436700347 @default.
• W2943670034 hasLocation W29436700348 @default.
• W2943670034 hasOpenAccess W2943670034 @default.
• W2943670034 hasPrimaryLocation W29436700341 @default.
• W2943670034 hasRelatedWork W12465354 @default.
• W2943670034 hasRelatedWork W1978006696 @default.
• W2943670034 hasRelatedWork W2023726491 @default.
• W2943670034 hasRelatedWork W2101202640 @default.
• W2943670034 hasRelatedWork W2128002469 @default.
• W2943670034 hasRelatedWork W2217625724 @default.
• W2943670034 hasRelatedWork W2342921944 @default.

• next