FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943702971> ?p ?o ?g. }

• W2943702971 abstract "Flaviviruses such as yellow fever virus (YFV), Zika virus (ZIKV), and dengue virus (DENV) are important human pathogens. A common flavivirus trait is the antagonism of interferon (IFN) signaling to enhance viral replication and spread. We report that like ZIKV NS5 and DENV NS5, YFV NS5 binds human STAT2 (hSTAT2) but not mouse STAT2 (mSTAT2), a type I IFN (IFN-α/β) pathway component. Additionally, we show that contrary to what has been demonstrated with ZIKV NS5 and DENV NS5, YFV NS5 is unable to interact with hSTAT2 in murine cells. We demonstrate that mSTAT2 restricts YFV replication in mice and that this correlates with a lack of IFN-α/β-induced YFV NS5 ubiquitination in murine cells. The lack of suitable animal models limits flavivirus pathogenesis, vaccine, and drug research. These data serve as further impetus for the development of an immunocompetent mouse model that can serve as a disease model for multiple flaviviruses." @default.
• W2943702971 created "2019-05-09" @default.
• W2943702971 creator A5008451966 @default.
• W2943702971 creator A5009071047 @default.
• W2943702971 creator A5011821997 @default.
• W2943702971 creator A5057631271 @default.
• W2943702971 creator A5059620970 @default.
• W2943702971 creator A5071789149 @default.
• W2943702971 creator A5085696847 @default.
• W2943702971 date "2019-07-15" @default.
• W2943702971 modified "2023-10-18" @default.
• W2943702971 title "Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism" @default.
• W2943702971 cites W1580729771 @default.
• W2943702971 cites W1986551392 @default.
• W2943702971 cites W1991536902 @default.
• W2943702971 cites W2006447162 @default.
• W2943702971 cites W2014247827 @default.
• W2943702971 cites W2021668929 @default.
• W2943702971 cites W2022687771 @default.
• W2943702971 cites W2036978861 @default.
• W2943702971 cites W2060969557 @default.
• W2943702971 cites W2074123822 @default.
• W2943702971 cites W2114724795 @default.
• W2943702971 cites W2121780828 @default.
• W2943702971 cites W2134669110 @default.
• W2943702971 cites W2138542194 @default.
• W2943702971 cites W2148425212 @default.
• W2943702971 cites W2151244977 @default.
• W2943702971 cites W2151712105 @default.
• W2943702971 cites W2339858561 @default.
• W2943702971 cites W2341966839 @default.
• W2943702971 cites W2395416726 @default.
• W2943702971 cites W2617995385 @default.
• W2943702971 cites W2797474345 @default.
• W2943702971 cites W2800329970 @default.
• W2943702971 doi "https://doi.org/10.1128/jvi.00151-19" @default.
• W2943702971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6600188" @default.
• W2943702971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31043530" @default.
• W2943702971 hasPublicationYear "2019" @default.
• W2943702971 type Work @default.
• W2943702971 sameAs 2943702971 @default.
• W2943702971 citedByCount "18" @default.
• W2943702971 countsByYear W29437029712019 @default.
• W2943702971 countsByYear W29437029712020 @default.
• W2943702971 countsByYear W29437029712021 @default.
• W2943702971 countsByYear W29437029712022 @default.
• W2943702971 countsByYear W29437029712023 @default.
• W2943702971 crossrefType "journal-article" @default.
• W2943702971 hasAuthorship W2943702971A5008451966 @default.
• W2943702971 hasAuthorship W2943702971A5009071047 @default.
• W2943702971 hasAuthorship W2943702971A5011821997 @default.
• W2943702971 hasAuthorship W2943702971A5057631271 @default.
• W2943702971 hasAuthorship W2943702971A5059620970 @default.
• W2943702971 hasAuthorship W2943702971A5071789149 @default.
• W2943702971 hasAuthorship W2943702971A5085696847 @default.
• W2943702971 hasBestOaLocation W29437029711 @default.
• W2943702971 hasConcept C104317684 @default.
• W2943702971 hasConcept C140704245 @default.
• W2943702971 hasConcept C159047783 @default.
• W2943702971 hasConcept C196594336 @default.
• W2943702971 hasConcept C2522874641 @default.
• W2943702971 hasConcept C25602115 @default.
• W2943702971 hasConcept C25897203 @default.
• W2943702971 hasConcept C2776178377 @default.
• W2943702971 hasConcept C2776239193 @default.
• W2943702971 hasConcept C2777053367 @default.
• W2943702971 hasConcept C2778277574 @default.
• W2943702971 hasConcept C2778923194 @default.
• W2943702971 hasConcept C2779131611 @default.
• W2943702971 hasConcept C2779635636 @default.
• W2943702971 hasConcept C2780568436 @default.
• W2943702971 hasConcept C533803919 @default.
• W2943702971 hasConcept C54355233 @default.
• W2943702971 hasConcept C62478195 @default.
• W2943702971 hasConcept C86803240 @default.
• W2943702971 hasConceptScore W2943702971C104317684 @default.
• W2943702971 hasConceptScore W2943702971C140704245 @default.
• W2943702971 hasConceptScore W2943702971C159047783 @default.
• W2943702971 hasConceptScore W2943702971C196594336 @default.
• W2943702971 hasConceptScore W2943702971C2522874641 @default.
• W2943702971 hasConceptScore W2943702971C25602115 @default.
• W2943702971 hasConceptScore W2943702971C25897203 @default.
• W2943702971 hasConceptScore W2943702971C2776178377 @default.
• W2943702971 hasConceptScore W2943702971C2776239193 @default.
• W2943702971 hasConceptScore W2943702971C2777053367 @default.
• W2943702971 hasConceptScore W2943702971C2778277574 @default.
• W2943702971 hasConceptScore W2943702971C2778923194 @default.
• W2943702971 hasConceptScore W2943702971C2779131611 @default.
• W2943702971 hasConceptScore W2943702971C2779635636 @default.
• W2943702971 hasConceptScore W2943702971C2780568436 @default.
• W2943702971 hasConceptScore W2943702971C533803919 @default.
• W2943702971 hasConceptScore W2943702971C54355233 @default.
• W2943702971 hasConceptScore W2943702971C62478195 @default.
• W2943702971 hasConceptScore W2943702971C86803240 @default.
• W2943702971 hasFunder F4320337355 @default.
• W2943702971 hasIssue "14" @default.
• W2943702971 hasLocation W29437029711 @default.
• W2943702971 hasLocation W29437029712 @default.
• W2943702971 hasLocation W29437029713 @default.
• W2943702971 hasLocation W29437029714 @default.

• next