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• W2943703765 abstract "Myoglobins (Mb) are ubiquitous proteins found in striated muscle of nearly all vertebrate taxa. Although their function is most commonly associated with facilitating oxygen storage and diffusion, Mb has also been implicated in cellular antioxidant defense. The oxidized (Fe3+) form of Mb (metMB) can react with hydrogen peroxide (H2O2) to produce ferrylMb. FerrylMb can be reduced back to metMb for another round of reaction with H2O2. In the present study, we have shown that horse skeletal muscle Mb displays peroxidase activity using 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) and 3,3',5,5'-tetramethylbenzidine (TMB) as reducing substrates, as well as the biologically-relevant substrates NADH/NADPH, ascorbate, caffeic acid, and resveratrol. We have also shown that ferrylMb can be reduced by both ethanol and acetaldehyde, which are known to accumulate in some vertebrate tissues under anaerobic conditions, such as anoxic goldfish and crucian carp, implying a potential mechanism for ethanol detoxification in striated muscle. We found that metMb peroxidase activity is pH-dependent, increasing as pH decreases from 7.4 to 6.1, which is biologically relevant to anaerobic vertebrate muscle when incurring intracellular lactic acidosis. Finally, we found that metMb reacts with hypochlorite in a heme-dependent fashion, indicating that Mb could play a role in hypochlorite detoxification. Taken together, these data suggest that Mb peroxidase activity might be an important antioxidant mechanism in vertebrate cardiac and skeletal muscle under a variety of physiological conditions, such as those that might occur in contracting skeletal muscle or during hypoxia." @default.
• W2943703765 created "2019-05-09" @default.
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• W2943703765 date "2019-08-01" @default.
• W2943703765 modified "2023-09-25" @default.
• W2943703765 title "Myoglobin as a versatile peroxidase: Implications for a more important role for vertebrate striated muscle in antioxidant defense" @default.
• W2943703765 cites W1041764543 @default.
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• W2943703765 cites W1576137866 @default.
• W2943703765 cites W1662116282 @default.
• W2943703765 cites W1676512302 @default.
• W2943703765 cites W1834861419 @default.
• W2943703765 cites W1938284750 @default.
• W2943703765 cites W1969050066 @default.
• W2943703765 cites W1970723676 @default.
• W2943703765 cites W1977461498 @default.
• W2943703765 cites W1984854126 @default.
• W2943703765 cites W1985645521 @default.
• W2943703765 cites W1987439191 @default.
• W2943703765 cites W1988012418 @default.
• W2943703765 cites W1993566791 @default.
• W2943703765 cites W1995629951 @default.
• W2943703765 cites W1996698251 @default.
• W2943703765 cites W2001029839 @default.
• W2943703765 cites W2001311668 @default.
• W2943703765 cites W2001477972 @default.
• W2943703765 cites W2013105387 @default.
• W2943703765 cites W2016402579 @default.
• W2943703765 cites W2017907872 @default.
• W2943703765 cites W2018564874 @default.
• W2943703765 cites W2019534267 @default.
• W2943703765 cites W2022255991 @default.
• W2943703765 cites W2028031080 @default.
• W2943703765 cites W2030351692 @default.
• W2943703765 cites W2032466859 @default.
• W2943703765 cites W2033968800 @default.
• W2943703765 cites W2036878092 @default.
• W2943703765 cites W2041245205 @default.
• W2943703765 cites W2043600550 @default.
• W2943703765 cites W2045676198 @default.
• W2943703765 cites W2049696812 @default.
• W2943703765 cites W2050228238 @default.
• W2943703765 cites W2059050788 @default.
• W2943703765 cites W2059365989 @default.
• W2943703765 cites W2059626889 @default.
• W2943703765 cites W2060982955 @default.
• W2943703765 cites W2062438924 @default.
• W2943703765 cites W2068513248 @default.
• W2943703765 cites W2068995800 @default.
• W2943703765 cites W2085160810 @default.
• W2943703765 cites W2085858063 @default.
• W2943703765 cites W2091900069 @default.
• W2943703765 cites W2092710202 @default.
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• W2943703765 cites W2097366028 @default.
• W2943703765 cites W2101851266 @default.
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• W2943703765 cites W2121058594 @default.
• W2943703765 cites W2122549757 @default.
• W2943703765 cites W2129550715 @default.
• W2943703765 cites W2133924652 @default.
• W2943703765 cites W2139633163 @default.
• W2943703765 cites W2139921047 @default.
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• W2943703765 cites W2158651198 @default.
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• W2943703765 doi "https://doi.org/10.1016/j.cbpb.2019.04.005" @default.
• W2943703765 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6594547" @default.
• W2943703765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31051268" @default.
• W2943703765 hasPublicationYear "2019" @default.
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