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- W2943728167 abstract "This project contributed to a greater understanding of chemotherapy resistance in non-small cell lung cancer (NSCLC), a prevalent issue to chemotherapy. The potential of the inflammatory transcription factor NF-ĸB as a therapeutic target was investigated to combat NSCLC chemo-resistance using in vitro and in vivo approaches. The activity of NF-ĸB was elucidated in models of chemo-resistant NSCLC and where specific inhibitors of NF-ĸB were used to block activity. In addition, a novel 3D model of chemo-resistance in NSCLC was generated which will serve as an important model in future studies." @default.
- W2943728167 created "2019-05-09" @default.
- W2943728167 creator A5030723372 @default.
- W2943728167 date "2019-03-20" @default.
- W2943728167 modified "2023-09-30" @default.
- W2943728167 title "Targeting the Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-kB) Pathway to Overcome Cisplatin-Resistance in Non-Small Cell Lung Cancer" @default.
- W2943728167 doi "https://doi.org/10.5204/thesis.eprints.127346" @default.
- W2943728167 hasPublicationYear "2019" @default.
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