Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943765829> ?p ?o ?g. }
- W2943765829 abstract "Campylobacter jejuni is a leading cause of diarrheal disease worldwide, and currently no preventative interventions are available. C. jejuni is an invasive mucosal pathogen that has a variety of polysaccharide structures on its surface, including a capsule. In phase 1 studies, a C. jejuni capsule conjugate vaccine was safe but poorly immunogenic when delivered alone or with aluminum hydroxide. Here, we report enhanced immunogenicity of the conjugate vaccine delivered with liposome adjuvants containing monophosphoryl lipid A without or with QS-21, known as ALF and ALFQ, respectively, in preclinical studies. Both liposome adjuvants significantly enhanced immunity in mice and nonhuman primates and improved protective efficacy of the vaccine compared to alum in a nonhuman primate C. jejuni diarrhea model, providing promising evidence that these potent adjuvant formulations may enhance immunogenicity in upcoming human studies with this C. jejuni conjugate and other malaria and HIV vaccine platforms." @default.
- W2943765829 created "2019-05-09" @default.
- W2943765829 creator A5005242730 @default.
- W2943765829 creator A5007536314 @default.
- W2943765829 creator A5019474861 @default.
- W2943765829 creator A5041370693 @default.
- W2943765829 creator A5042773923 @default.
- W2943765829 creator A5046258962 @default.
- W2943765829 creator A5060536761 @default.
- W2943765829 creator A5063956962 @default.
- W2943765829 creator A5070304475 @default.
- W2943765829 creator A5076380897 @default.
- W2943765829 creator A5077203387 @default.
- W2943765829 creator A5079610765 @default.
- W2943765829 creator A5081892432 @default.
- W2943765829 creator A5090163922 @default.
- W2943765829 creator A5090285114 @default.
- W2943765829 creator A5048942657 @default.
- W2943765829 date "2019-06-26" @default.
- W2943765829 modified "2023-09-25" @default.
- W2943765829 title "Enhanced Immunogenicity and Protective Efficacy of a <i>Campylobacter jejuni</i> Conjugate Vaccine Coadministered with Liposomes Containing Monophosphoryl Lipid A and QS-21" @default.
- W2943765829 cites W1549807114 @default.
- W2943765829 cites W1549874587 @default.
- W2943765829 cites W1631727505 @default.
- W2943765829 cites W1810620487 @default.
- W2943765829 cites W1821981622 @default.
- W2943765829 cites W1967184051 @default.
- W2943765829 cites W1971892454 @default.
- W2943765829 cites W1978153776 @default.
- W2943765829 cites W1986537688 @default.
- W2943765829 cites W2004976172 @default.
- W2943765829 cites W2005143719 @default.
- W2943765829 cites W2006514982 @default.
- W2943765829 cites W2018391577 @default.
- W2943765829 cites W2018717839 @default.
- W2943765829 cites W2020838028 @default.
- W2943765829 cites W2025923493 @default.
- W2943765829 cites W2046577329 @default.
- W2943765829 cites W2052517312 @default.
- W2943765829 cites W2052800627 @default.
- W2943765829 cites W2068438592 @default.
- W2943765829 cites W2072347337 @default.
- W2943765829 cites W2076361043 @default.
- W2943765829 cites W2088739869 @default.
- W2943765829 cites W2094204413 @default.
- W2943765829 cites W2094496555 @default.
- W2943765829 cites W2095356313 @default.
- W2943765829 cites W2098489670 @default.
- W2943765829 cites W2099015315 @default.
- W2943765829 cites W2099043437 @default.
- W2943765829 cites W2103861804 @default.
- W2943765829 cites W2106690709 @default.
- W2943765829 cites W2114053580 @default.
- W2943765829 cites W2125509757 @default.
- W2943765829 cites W2128154577 @default.
- W2943765829 cites W2128214209 @default.
- W2943765829 cites W2130754817 @default.
- W2943765829 cites W2135946578 @default.
- W2943765829 cites W2140598855 @default.
- W2943765829 cites W2142993603 @default.
- W2943765829 cites W2152089549 @default.
- W2943765829 cites W2159162370 @default.
- W2943765829 cites W2159225230 @default.
- W2943765829 cites W2161193441 @default.
- W2943765829 cites W2165612340 @default.
- W2943765829 cites W2170382285 @default.
- W2943765829 cites W2174836001 @default.
- W2943765829 cites W2185023692 @default.
- W2943765829 cites W2411048305 @default.
- W2943765829 cites W2484771392 @default.
- W2943765829 cites W2513619720 @default.
- W2943765829 cites W2517496869 @default.
- W2943765829 cites W2593336615 @default.
- W2943765829 cites W2607198699 @default.
- W2943765829 cites W2610326848 @default.
- W2943765829 cites W2623747941 @default.
- W2943765829 cites W2781899702 @default.
- W2943765829 cites W2893533628 @default.
- W2943765829 cites W2893561460 @default.
- W2943765829 cites W2949659481 @default.
- W2943765829 doi "https://doi.org/10.1128/msphere.00101-19" @default.
- W2943765829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6495334" @default.
- W2943765829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31043512" @default.
- W2943765829 hasPublicationYear "2019" @default.
- W2943765829 type Work @default.
- W2943765829 sameAs 2943765829 @default.
- W2943765829 citedByCount "9" @default.
- W2943765829 countsByYear W29437658292020 @default.
- W2943765829 countsByYear W29437658292021 @default.
- W2943765829 countsByYear W29437658292022 @default.
- W2943765829 countsByYear W29437658292023 @default.
- W2943765829 crossrefType "journal-article" @default.
- W2943765829 hasAuthorship W2943765829A5005242730 @default.
- W2943765829 hasAuthorship W2943765829A5007536314 @default.
- W2943765829 hasAuthorship W2943765829A5019474861 @default.
- W2943765829 hasAuthorship W2943765829A5041370693 @default.
- W2943765829 hasAuthorship W2943765829A5042773923 @default.
- W2943765829 hasAuthorship W2943765829A5046258962 @default.
- W2943765829 hasAuthorship W2943765829A5048942657 @default.
- W2943765829 hasAuthorship W2943765829A5060536761 @default.