FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943783062> ?p ?o ?g. }

• W2943783062 endingPage "479" @default.
• W2943783062 startingPage "472" @default.
• W2943783062 abstract "Stevia has exhibited antioxidant, antihyperglycemic, antihypertensive and anti-inflammatory properties in several in vivo and in vitro models. The objective of this study was to investigate the ability of an aqueous extract of stevia (AES) to prevent experimental cirrhosis in rats and to explore its mechanism of action.Liver cirrhosis was induced by administering carbon tetrachloride (CCl4) (400mg/kg by i.p. injection 3 times a week for 12 weeks); AES was administered (100mg/kg by gavage daily) during the CCl4 treatment. Fibrosis was evaluated with histological, biochemical and molecular approaches, and liver damage was assessed with standardized procedures. The profibrotic pathways were analyzed by western blotting, qRT-PCR and immunohistochemistry.Chronic CCl4 administration increased nuclear factor kappa B (NF-κB) and proinflammatory cytokine production as well as oxidative parameters such as lipid peroxidation and 4-hydroxynonenal levels, whereas GSH and nuclear factor-E2-related factor 2 (Nrf2) levels were decreased. CCl4 induced profibrogenic mediator expression, hepatic stellate cell (HSC) activation and, consequently, extracellular matrix production. AES exhibited antioxidant, anti-inflammatory and antifibrotic properties, probably because of its capacity to induce Nrf2 expression, reduce NF-κB expression and block several profibrogenic signaling pathways, subsequently inhibiting HSC activation and preventing fibrosis induced by chronic CCl4 administration." @default.
• W2943783062 created "2019-05-09" @default.
• W2943783062 creator A5000790159 @default.
• W2943783062 creator A5016087971 @default.
• W2943783062 creator A5032718913 @default.
• W2943783062 creator A5054786932 @default.
• W2943783062 creator A5071399162 @default.
• W2943783062 creator A5082776061 @default.
• W2943783062 date "2019-05-01" @default.
• W2943783062 modified "2023-09-25" @default.
• W2943783062 title "An aqueous extract of Stevia rebaudiana variety Morita II prevents liver damage in a rat model of cirrhosis that mimics the human disease" @default.
• W2943783062 cites W1970716479 @default.
• W2943783062 cites W1976777085 @default.
• W2943783062 cites W1978588596 @default.
• W2943783062 cites W1985385891 @default.
• W2943783062 cites W1986213914 @default.
• W2943783062 cites W1987508487 @default.
• W2943783062 cites W1988149166 @default.
• W2943783062 cites W1990399859 @default.
• W2943783062 cites W1997966080 @default.
• W2943783062 cites W1998214223 @default.
• W2943783062 cites W2000305784 @default.
• W2943783062 cites W2003908423 @default.
• W2943783062 cites W2005401366 @default.
• W2943783062 cites W2028823750 @default.
• W2943783062 cites W2032110509 @default.
• W2943783062 cites W2045688134 @default.
• W2943783062 cites W2048372148 @default.
• W2943783062 cites W2049039666 @default.
• W2943783062 cites W2061868505 @default.
• W2943783062 cites W2074536653 @default.
• W2943783062 cites W2083068177 @default.
• W2943783062 cites W2085355045 @default.
• W2943783062 cites W2103110170 @default.
• W2943783062 cites W2107277218 @default.
• W2943783062 cites W2109748669 @default.
• W2943783062 cites W2112416319 @default.
• W2943783062 cites W2119969269 @default.
• W2943783062 cites W2166192011 @default.
• W2943783062 cites W2565367159 @default.
• W2943783062 cites W2613180696 @default.
• W2943783062 cites W2613460655 @default.
• W2943783062 cites W2722130257 @default.
• W2943783062 cites W2742956172 @default.
• W2943783062 cites W2793484183 @default.
• W2943783062 cites W2802998469 @default.
• W2943783062 doi "https://doi.org/10.1016/j.aohep.2018.10.002" @default.
• W2943783062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31053541" @default.
• W2943783062 hasPublicationYear "2019" @default.
• W2943783062 type Work @default.
• W2943783062 sameAs 2943783062 @default.
• W2943783062 citedByCount "15" @default.
• W2943783062 countsByYear W29437830622019 @default.
• W2943783062 countsByYear W29437830622020 @default.
• W2943783062 countsByYear W29437830622022 @default.
• W2943783062 countsByYear W29437830622023 @default.
• W2943783062 crossrefType "journal-article" @default.
• W2943783062 hasAuthorship W2943783062A5000790159 @default.
• W2943783062 hasAuthorship W2943783062A5016087971 @default.
• W2943783062 hasAuthorship W2943783062A5032718913 @default.
• W2943783062 hasAuthorship W2943783062A5054786932 @default.
• W2943783062 hasAuthorship W2943783062A5071399162 @default.
• W2943783062 hasAuthorship W2943783062A5082776061 @default.
• W2943783062 hasBestOaLocation W29437830621 @default.
• W2943783062 hasConcept C102124568 @default.
• W2943783062 hasConcept C126322002 @default.
• W2943783062 hasConcept C164027704 @default.
• W2943783062 hasConcept C176891718 @default.
• W2943783062 hasConcept C178790620 @default.
• W2943783062 hasConcept C185592680 @default.
• W2943783062 hasConcept C2776151105 @default.
• W2943783062 hasConcept C2776914184 @default.
• W2943783062 hasConcept C2777214474 @default.
• W2943783062 hasConcept C2777359374 @default.
• W2943783062 hasConcept C2778004101 @default.
• W2943783062 hasConcept C2780559512 @default.
• W2943783062 hasConcept C2780829032 @default.
• W2943783062 hasConcept C2992134379 @default.
• W2943783062 hasConcept C2993667909 @default.
• W2943783062 hasConcept C31903555 @default.
• W2943783062 hasConcept C55493867 @default.
• W2943783062 hasConcept C71924100 @default.
• W2943783062 hasConcept C98274493 @default.
• W2943783062 hasConceptScore W2943783062C102124568 @default.
• W2943783062 hasConceptScore W2943783062C126322002 @default.
• W2943783062 hasConceptScore W2943783062C164027704 @default.
• W2943783062 hasConceptScore W2943783062C176891718 @default.
• W2943783062 hasConceptScore W2943783062C178790620 @default.
• W2943783062 hasConceptScore W2943783062C185592680 @default.
• W2943783062 hasConceptScore W2943783062C2776151105 @default.
• W2943783062 hasConceptScore W2943783062C2776914184 @default.
• W2943783062 hasConceptScore W2943783062C2777214474 @default.
• W2943783062 hasConceptScore W2943783062C2777359374 @default.
• W2943783062 hasConceptScore W2943783062C2778004101 @default.
• W2943783062 hasConceptScore W2943783062C2780559512 @default.
• W2943783062 hasConceptScore W2943783062C2780829032 @default.
• W2943783062 hasConceptScore W2943783062C2992134379 @default.
• W2943783062 hasConceptScore W2943783062C2993667909 @default.

• next