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- W2943813939 abstract "Damjanov and Meropol review the status of several oral fluoropyrimidine drugs that are currently undergoing clinical testing for the treatment of colorectal cancer. Meta-analysis indicates an 8% improvement in the overall response rate and a survival advantage of 0.8 months with infusional vs bolus fluorouracil (5-FU)—arguably small differences. The incidence of grade 3-4 diarrhea, mucositis, and myelosuppression is < 10% with infusional 5-FU, although hand-foot syndrome is commonly associated with this therapy. The prevailing strategy for the development of oral 5-FU drugs employs multiple daily dosing for periods of 2 to 4 weeks followed by a 1- or 2-week break in order to mimic the protracted infusional schedule. UFT" @default.
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- W2943813939 date "2000-06-01" @default.
- W2943813939 modified "2023-09-27" @default.
- W2943813939 title "Oral Therapy for Colorectal Cancer: How to Choose" @default.
- W2943813939 hasPublicationYear "2000" @default.
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