Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943843423> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2943843423 endingPage "87" @default.
- W2943843423 startingPage "83" @default.
- W2943843423 abstract "Acute myeloid leukemia (AML) is an aggressive cancer that remains lethal to the majority of sufferers. Whilst the mainstay treatments for this condition have remained largely unchanged over the past five decades, progress in deciphering its pathogenesis has accelerated in recent years, propelled in part by advances in cancer genomics and mechanistic studies of leukemogenic mutations. Newer molecular therapies targeting aberrant biological pathways are currently under investigation with a few moving closer to clinical use. However, collectively, these new therapies are not predicted to have a major impact on clinical outcomes and the need for the identification of further therapeutic targets in AML remains critical. Recently the use of CRISPR-Cas9 systems for genome editing and their potential application in genome-wide screening has opened a new frontier for unbiased discovery of therapeutic vulnerabilities in cancer and AML was the first disease in which this technology was systematically applied. In this review we give an overview of recent advances in identifying novel therapeutic vulnerabilities of AML using CRISPR-Cas9 and discuss possible future applications of CRISPR technologies in this field." @default.
- W2943843423 created "2019-05-16" @default.
- W2943843423 creator A5019260569 @default.
- W2943843423 creator A5024724352 @default.
- W2943843423 date "2019-02-01" @default.
- W2943843423 modified "2023-09-24" @default.
- W2943843423 title "Genome-scale drop-out screens to identify cancer cell vulnerabilities in AML" @default.
- W2943843423 cites W1255676896 @default.
- W2943843423 cites W1635615463 @default.
- W2943843423 cites W1982846895 @default.
- W2943843423 cites W2003171404 @default.
- W2943843423 cites W2012753533 @default.
- W2943843423 cites W2026592619 @default.
- W2943843423 cites W2037856618 @default.
- W2943843423 cites W2045435533 @default.
- W2943843423 cites W2050480410 @default.
- W2943843423 cites W2054945577 @default.
- W2943843423 cites W2064815984 @default.
- W2943843423 cites W2068427957 @default.
- W2943843423 cites W2069918359 @default.
- W2943843423 cites W2111866362 @default.
- W2943843423 cites W2123746851 @default.
- W2943843423 cites W2129129812 @default.
- W2943843423 cites W2131395804 @default.
- W2943843423 cites W2137315132 @default.
- W2943843423 cites W2137881702 @default.
- W2943843423 cites W2143835472 @default.
- W2943843423 cites W2153010521 @default.
- W2943843423 cites W2520159331 @default.
- W2943843423 cites W2533641274 @default.
- W2943843423 cites W2549790759 @default.
- W2943843423 cites W2584033231 @default.
- W2943843423 cites W2592787461 @default.
- W2943843423 cites W2597646117 @default.
- W2943843423 cites W2715749014 @default.
- W2943843423 cites W2765390373 @default.
- W2943843423 cites W2769630486 @default.
- W2943843423 cites W2884473318 @default.
- W2943843423 cites W2898284215 @default.
- W2943843423 cites W2899412336 @default.
- W2943843423 cites W2904132382 @default.
- W2943843423 cites W4241093998 @default.
- W2943843423 cites W4323517797 @default.
- W2943843423 doi "https://doi.org/10.1016/j.gde.2019.04.004" @default.
- W2943843423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31063922" @default.
- W2943843423 hasPublicationYear "2019" @default.
- W2943843423 type Work @default.
- W2943843423 sameAs 2943843423 @default.
- W2943843423 citedByCount "2" @default.
- W2943843423 countsByYear W29438434232021 @default.
- W2943843423 countsByYear W29438434232022 @default.
- W2943843423 crossrefType "journal-article" @default.
- W2943843423 hasAuthorship W2943843423A5019260569 @default.
- W2943843423 hasAuthorship W2943843423A5024724352 @default.
- W2943843423 hasConcept C104317684 @default.
- W2943843423 hasConcept C121332964 @default.
- W2943843423 hasConcept C121608353 @default.
- W2943843423 hasConcept C141231307 @default.
- W2943843423 hasConcept C2778755073 @default.
- W2943843423 hasConcept C502942594 @default.
- W2943843423 hasConcept C54355233 @default.
- W2943843423 hasConcept C62520636 @default.
- W2943843423 hasConcept C70721500 @default.
- W2943843423 hasConcept C86803240 @default.
- W2943843423 hasConceptScore W2943843423C104317684 @default.
- W2943843423 hasConceptScore W2943843423C121332964 @default.
- W2943843423 hasConceptScore W2943843423C121608353 @default.
- W2943843423 hasConceptScore W2943843423C141231307 @default.
- W2943843423 hasConceptScore W2943843423C2778755073 @default.
- W2943843423 hasConceptScore W2943843423C502942594 @default.
- W2943843423 hasConceptScore W2943843423C54355233 @default.
- W2943843423 hasConceptScore W2943843423C62520636 @default.
- W2943843423 hasConceptScore W2943843423C70721500 @default.
- W2943843423 hasConceptScore W2943843423C86803240 @default.
- W2943843423 hasFunder F4320307874 @default.
- W2943843423 hasFunder F4320308295 @default.
- W2943843423 hasFunder F4320319985 @default.
- W2943843423 hasFunder F4320319990 @default.
- W2943843423 hasFunder F4320320104 @default.
- W2943843423 hasFunder F4320334678 @default.
- W2943843423 hasLocation W29438434231 @default.
- W2943843423 hasOpenAccess W2943843423 @default.
- W2943843423 hasPrimaryLocation W29438434231 @default.
- W2943843423 hasRelatedWork W1828691184 @default.
- W2943843423 hasRelatedWork W1903732681 @default.
- W2943843423 hasRelatedWork W1991523530 @default.
- W2943843423 hasRelatedWork W2002128513 @default.
- W2943843423 hasRelatedWork W2030640333 @default.
- W2943843423 hasRelatedWork W2031436818 @default.
- W2943843423 hasRelatedWork W2057739827 @default.
- W2943843423 hasRelatedWork W2075354549 @default.
- W2943843423 hasRelatedWork W3164573509 @default.
- W2943843423 hasRelatedWork W2092874662 @default.
- W2943843423 hasVolume "54" @default.
- W2943843423 isParatext "false" @default.
- W2943843423 isRetracted "false" @default.
- W2943843423 magId "2943843423" @default.
- W2943843423 workType "article" @default.