FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943859098> ?p ?o ?g. }

• W2943859098 endingPage "3389" @default.
• W2943859098 startingPage "3374" @default.
• W2943859098 abstract "BACKGROUND The protein 4.1 family is a family of cytoskeletal proteins that play an important role in maintaining normal cell morphology and cell adhesion, migration, division, and intercellular signaling. The main aim of this study was to explore the prognostic significance of the protein 4.1 family in breast cancer (BC) patients and to provide new biomarkers and therapeutic targets for the diagnosis and treatment of BC. MATERIAL AND METHODS The expression of 4.1 family members in various tumor types was compared to normal controls using the ONCOMINE and GOBO databases. The prognostic significance of the 4.1 family in BC patients was determined by Kaplan-Meier Plotter. RESULTS EPB41L2 (4.1G) was expressed at higher levels in normal tissues compared with BC patients for all 4.1 family members. In survival analysis, 4.1G and EPB41 (4.1R) mRNA high expressions were associated with better survival in BC patients. Moreover, 4.1G high expression was significantly associated with longer overall survival (OS) in luminal A and protracted relapse-free survival (RFS) in luminal B subtype BC patients who received Tamoxifen treatment. In addition, high expression of each 4.1 family member also showed better prognostic value in different molecular subtypes of BC. CONCLUSIONS These results indicate that the protein 4.1 family can be regarded as novel biomarkers and potential therapeutic targets for BC. Further research is needed to explore the detailed biological functions." @default.
• W2943859098 created "2019-05-16" @default.
• W2943859098 creator A5007179023 @default.
• W2943859098 creator A5025812490 @default.
• W2943859098 creator A5031231298 @default.
• W2943859098 creator A5064288450 @default.
• W2943859098 creator A5071703303 @default.
• W2943859098 creator A5074742805 @default.
• W2943859098 creator A5090993403 @default.
• W2943859098 date "2019-05-07" @default.
• W2943859098 modified "2023-10-12" @default.
• W2943859098 title "Expression of Protein 4.1 Family in Breast Cancer: Database Mining for 4.1 Family Members in Malignancies" @default.
• W2943859098 cites W1931530489 @default.
• W2943859098 cites W1964840643 @default.
• W2943859098 cites W1965550460 @default.
• W2943859098 cites W1968863074 @default.
• W2943859098 cites W1968870340 @default.
• W2943859098 cites W1979468053 @default.
• W2943859098 cites W1986724703 @default.
• W2943859098 cites W1994919541 @default.
• W2943859098 cites W1998206264 @default.
• W2943859098 cites W2016506024 @default.
• W2943859098 cites W2028307324 @default.
• W2943859098 cites W2031037227 @default.
• W2943859098 cites W2054377432 @default.
• W2943859098 cites W2059537862 @default.
• W2943859098 cites W2068509272 @default.
• W2943859098 cites W2072003338 @default.
• W2943859098 cites W2083002009 @default.
• W2943859098 cites W2094433259 @default.
• W2943859098 cites W2096917532 @default.
• W2943859098 cites W2097482618 @default.
• W2943859098 cites W2097896616 @default.
• W2943859098 cites W2119655833 @default.
• W2943859098 cites W2134908784 @default.
• W2943859098 cites W2147343434 @default.
• W2943859098 cites W2151763534 @default.
• W2943859098 cites W2264559502 @default.
• W2943859098 cites W2268641015 @default.
• W2943859098 cites W2272984102 @default.
• W2943859098 cites W2276985297 @default.
• W2943859098 cites W2327774474 @default.
• W2943859098 cites W2399920194 @default.
• W2943859098 cites W2531294657 @default.
• W2943859098 cites W2749365082 @default.
• W2943859098 cites W2774918089 @default.
• W2943859098 cites W2781525129 @default.
• W2943859098 cites W2792056622 @default.
• W2943859098 cites W2802469215 @default.
• W2943859098 cites W2806229604 @default.
• W2943859098 cites W2897140439 @default.
• W2943859098 cites W2977732097 @default.
• W2943859098 doi "https://doi.org/10.12659/msm.914085" @default.
• W2943859098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6524556" @default.
• W2943859098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31063460" @default.
• W2943859098 hasPublicationYear "2019" @default.
• W2943859098 type Work @default.
• W2943859098 sameAs 2943859098 @default.
• W2943859098 citedByCount "6" @default.
• W2943859098 countsByYear W29438590982020 @default.
• W2943859098 countsByYear W29438590982021 @default.
• W2943859098 countsByYear W29438590982023 @default.
• W2943859098 crossrefType "journal-article" @default.
• W2943859098 hasAuthorship W2943859098A5007179023 @default.
• W2943859098 hasAuthorship W2943859098A5025812490 @default.
• W2943859098 hasAuthorship W2943859098A5031231298 @default.
• W2943859098 hasAuthorship W2943859098A5064288450 @default.
• W2943859098 hasAuthorship W2943859098A5071703303 @default.
• W2943859098 hasAuthorship W2943859098A5074742805 @default.
• W2943859098 hasAuthorship W2943859098A5090993403 @default.
• W2943859098 hasBestOaLocation W29438590982 @default.
• W2943859098 hasConcept C104317684 @default.
• W2943859098 hasConcept C10515644 @default.
• W2943859098 hasConcept C121608353 @default.
• W2943859098 hasConcept C126322002 @default.
• W2943859098 hasConcept C143998085 @default.
• W2943859098 hasConcept C171897839 @default.
• W2943859098 hasConcept C2777176818 @default.
• W2943859098 hasConcept C2781179581 @default.
• W2943859098 hasConcept C502942594 @default.
• W2943859098 hasConcept C530470458 @default.
• W2943859098 hasConcept C54355233 @default.
• W2943859098 hasConcept C60644358 @default.
• W2943859098 hasConcept C71924100 @default.
• W2943859098 hasConcept C86803240 @default.
• W2943859098 hasConceptScore W2943859098C104317684 @default.
• W2943859098 hasConceptScore W2943859098C10515644 @default.
• W2943859098 hasConceptScore W2943859098C121608353 @default.
• W2943859098 hasConceptScore W2943859098C126322002 @default.
• W2943859098 hasConceptScore W2943859098C143998085 @default.
• W2943859098 hasConceptScore W2943859098C171897839 @default.
• W2943859098 hasConceptScore W2943859098C2777176818 @default.
• W2943859098 hasConceptScore W2943859098C2781179581 @default.
• W2943859098 hasConceptScore W2943859098C502942594 @default.
• W2943859098 hasConceptScore W2943859098C530470458 @default.
• W2943859098 hasConceptScore W2943859098C54355233 @default.
• W2943859098 hasConceptScore W2943859098C60644358 @default.
• W2943859098 hasConceptScore W2943859098C71924100 @default.

• next