Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943885243> ?p ?o ?g. }
- W2943885243 endingPage "8681" @default.
- W2943885243 startingPage "8665" @default.
- W2943885243 abstract "Multiple approaches have been developed to combat bacterial resistance. However, the combination of antibiotic resistance mechanisms by bacteria and the limited number of effective antibiotics available decreases the effective interventions for the treatment of current bacterial infections. This review covers the many ways that bacteria resist antibiotics including antibiotic target modification, the use of efflux pumps, and antibiotic inactivation. As a pertinent example, the use of beta lactamase inhibitors in combination with β-lactam containing antibiotics is discussed in detail. The solution to emerging antibiotic resistance may involve combination therapies of existing antibiotics and potentiating adjuvants, which re-empower the antibiotic agent to become efficacious against the resistant strain of interest. We report herein that a reasoned adjuvant design permits one to perform polypharmacy on bacteria by not only providing greater internal access to the codosed antibiotics but also by de-energizing the efflux pumps used by the bacteria to escape antibiotic action." @default.
- W2943885243 created "2019-05-16" @default.
- W2943885243 creator A5039946471 @default.
- W2943885243 creator A5061103449 @default.
- W2943885243 creator A5079082784 @default.
- W2943885243 creator A5089135121 @default.
- W2943885243 date "2019-05-07" @default.
- W2943885243 modified "2023-10-13" @default.
- W2943885243 title "Antibiotic Adjuvants: Make Antibiotics Great Again!" @default.
- W2943885243 cites W1164126203 @default.
- W2943885243 cites W1598136901 @default.
- W2943885243 cites W1691012859 @default.
- W2943885243 cites W1820140377 @default.
- W2943885243 cites W1889500336 @default.
- W2943885243 cites W1895007034 @default.
- W2943885243 cites W1895129045 @default.
- W2943885243 cites W1916459461 @default.
- W2943885243 cites W1927502485 @default.
- W2943885243 cites W1955222196 @default.
- W2943885243 cites W1964894938 @default.
- W2943885243 cites W1970975622 @default.
- W2943885243 cites W1975361143 @default.
- W2943885243 cites W1978646546 @default.
- W2943885243 cites W1979192175 @default.
- W2943885243 cites W1980655272 @default.
- W2943885243 cites W1981267913 @default.
- W2943885243 cites W1981905129 @default.
- W2943885243 cites W1982278009 @default.
- W2943885243 cites W1989761771 @default.
- W2943885243 cites W1989816709 @default.
- W2943885243 cites W1995547459 @default.
- W2943885243 cites W2006596001 @default.
- W2943885243 cites W2007331931 @default.
- W2943885243 cites W2010428513 @default.
- W2943885243 cites W2012706507 @default.
- W2943885243 cites W2012764667 @default.
- W2943885243 cites W2014818833 @default.
- W2943885243 cites W2016366979 @default.
- W2943885243 cites W2019293613 @default.
- W2943885243 cites W2019950016 @default.
- W2943885243 cites W2020137961 @default.
- W2943885243 cites W2020269649 @default.
- W2943885243 cites W2029154466 @default.
- W2943885243 cites W2032054300 @default.
- W2943885243 cites W2034692089 @default.
- W2943885243 cites W2035474027 @default.
- W2943885243 cites W2037223904 @default.
- W2943885243 cites W2040811291 @default.
- W2943885243 cites W2042656577 @default.
- W2943885243 cites W2046501778 @default.
- W2943885243 cites W2046839373 @default.
- W2943885243 cites W2048269999 @default.
- W2943885243 cites W2052525877 @default.
- W2943885243 cites W2058952776 @default.
- W2943885243 cites W2062000458 @default.
- W2943885243 cites W2073060607 @default.
- W2943885243 cites W2076233570 @default.
- W2943885243 cites W2076427840 @default.
- W2943885243 cites W2078389761 @default.
- W2943885243 cites W2078622972 @default.
- W2943885243 cites W2081442563 @default.
- W2943885243 cites W2084180225 @default.
- W2943885243 cites W2089559505 @default.
- W2943885243 cites W2090568896 @default.
- W2943885243 cites W2090845154 @default.
- W2943885243 cites W2091219913 @default.
- W2943885243 cites W2092825833 @default.
- W2943885243 cites W2095793325 @default.
- W2943885243 cites W2096629830 @default.
- W2943885243 cites W2097882907 @default.
- W2943885243 cites W2106372627 @default.
- W2943885243 cites W2107869853 @default.
- W2943885243 cites W2108429043 @default.
- W2943885243 cites W2111059574 @default.
- W2943885243 cites W2112586763 @default.
- W2943885243 cites W2120061656 @default.
- W2943885243 cites W2129003791 @default.
- W2943885243 cites W2129026291 @default.
- W2943885243 cites W2129825395 @default.
- W2943885243 cites W2131256712 @default.
- W2943885243 cites W2131293938 @default.
- W2943885243 cites W2131946678 @default.
- W2943885243 cites W2138999913 @default.
- W2943885243 cites W2140030464 @default.
- W2943885243 cites W2148964027 @default.
- W2943885243 cites W2151496242 @default.
- W2943885243 cites W2152512157 @default.
- W2943885243 cites W2155122915 @default.
- W2943885243 cites W2159861471 @default.
- W2943885243 cites W2159875565 @default.
- W2943885243 cites W2160637002 @default.
- W2943885243 cites W2192522212 @default.
- W2943885243 cites W2198287101 @default.
- W2943885243 cites W2261926027 @default.
- W2943885243 cites W2314734040 @default.
- W2943885243 cites W2319677515 @default.
- W2943885243 cites W2327014777 @default.
- W2943885243 cites W2328678115 @default.