Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943890907> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2943890907 endingPage "124" @default.
- W2943890907 startingPage "113" @default.
- W2943890907 abstract "A simple, rapid, accurate, reproducible and sensitive reverse phase HPLC method for the estimation of fusidic acid (FA) by means of Analytical Quality by Design (AQbD) was the aim of the present study. Initially, the vital pre-requisites for AQbD like analytical method target profile and critical analytical attributes (CAAs) like theoretical plates, tailing factor and percent assay were defined. An octadecyl silyl silica C18 column with a packing size of 5 μm was employed and the detection was performed at 235 nm using UV-detector. The separation was performed with isocratic elution employing mixture of methanol: acetonitrile (5: 95, v/v) and an aqueous phase with pH of 2.8 containing 0.1% orthophosphoric acid in the ratio of 60: 40 (v/v). Ishikawa fish-bone diagram provided the basis of the variation in CAAs with various inputs. Taguchi Design was selected as the initial screening design to select critical method parameters (CMPs) affecting method development and Central Composite Design (CCD) was further applied for systematic optimization of chromatographic method by evaluating CAAs. Crucial parameters viz. limit of detection, limit of quantification, specificity, linearity and sensitivity were employed to validate the method in accordance with the ICH guidelines. Stress degradation studies were performed and the developed method was able to successfully differentiate the degraded products from the parent drug, that too in a topical gel. In conclusion, the findings of the present study validated the utility of AQbD in the systematic design of a liquid chromatographic method with fine sensitivity for FA estimation in medicinal products." @default.
- W2943890907 created "2019-05-16" @default.
- W2943890907 creator A5001539239 @default.
- W2943890907 creator A5076338609 @default.
- W2943890907 creator A5077089491 @default.
- W2943890907 creator A5087811607 @default.
- W2943890907 date "2019-07-01" @default.
- W2943890907 modified "2023-10-18" @default.
- W2943890907 title "Stability kinetics of fusidic acid: Development and validation of stability indicating analytical method by employing Analytical Quality by Design approach in medicinal product(s)" @default.
- W2943890907 cites W1942324729 @default.
- W2943890907 cites W1986984633 @default.
- W2943890907 cites W1999180255 @default.
- W2943890907 cites W2006905047 @default.
- W2943890907 cites W2009965055 @default.
- W2943890907 cites W2045932532 @default.
- W2943890907 cites W2080106297 @default.
- W2943890907 cites W2085104905 @default.
- W2943890907 cites W2085414876 @default.
- W2943890907 cites W2101758885 @default.
- W2943890907 cites W2118586938 @default.
- W2943890907 cites W2139700691 @default.
- W2943890907 cites W2141606854 @default.
- W2943890907 cites W2163441678 @default.
- W2943890907 cites W2254447995 @default.
- W2943890907 cites W2404395160 @default.
- W2943890907 cites W2743701001 @default.
- W2943890907 cites W2771866427 @default.
- W2943890907 cites W2794379170 @default.
- W2943890907 cites W2801944387 @default.
- W2943890907 cites W978294694 @default.
- W2943890907 doi "https://doi.org/10.1016/j.jchromb.2019.05.001" @default.
- W2943890907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31082718" @default.
- W2943890907 hasPublicationYear "2019" @default.
- W2943890907 type Work @default.
- W2943890907 sameAs 2943890907 @default.
- W2943890907 citedByCount "19" @default.
- W2943890907 countsByYear W29438909072019 @default.
- W2943890907 countsByYear W29438909072020 @default.
- W2943890907 countsByYear W29438909072021 @default.
- W2943890907 countsByYear W29438909072022 @default.
- W2943890907 countsByYear W29438909072023 @default.
- W2943890907 crossrefType "journal-article" @default.
- W2943890907 hasAuthorship W2943890907A5001539239 @default.
- W2943890907 hasAuthorship W2943890907A5076338609 @default.
- W2943890907 hasAuthorship W2943890907A5077089491 @default.
- W2943890907 hasAuthorship W2943890907A5087811607 @default.
- W2943890907 hasConcept C119128265 @default.
- W2943890907 hasConcept C147789679 @default.
- W2943890907 hasConcept C150077022 @default.
- W2943890907 hasConcept C179998833 @default.
- W2943890907 hasConcept C185592680 @default.
- W2943890907 hasConcept C187530423 @default.
- W2943890907 hasConcept C204320433 @default.
- W2943890907 hasConcept C43617362 @default.
- W2943890907 hasConcept C92397422 @default.
- W2943890907 hasConceptScore W2943890907C119128265 @default.
- W2943890907 hasConceptScore W2943890907C147789679 @default.
- W2943890907 hasConceptScore W2943890907C150077022 @default.
- W2943890907 hasConceptScore W2943890907C179998833 @default.
- W2943890907 hasConceptScore W2943890907C185592680 @default.
- W2943890907 hasConceptScore W2943890907C187530423 @default.
- W2943890907 hasConceptScore W2943890907C204320433 @default.
- W2943890907 hasConceptScore W2943890907C43617362 @default.
- W2943890907 hasConceptScore W2943890907C92397422 @default.
- W2943890907 hasLocation W29438909071 @default.
- W2943890907 hasLocation W29438909072 @default.
- W2943890907 hasOpenAccess W2943890907 @default.
- W2943890907 hasPrimaryLocation W29438909071 @default.
- W2943890907 hasRelatedWork W1603333022 @default.
- W2943890907 hasRelatedWork W1964259887 @default.
- W2943890907 hasRelatedWork W1998279148 @default.
- W2943890907 hasRelatedWork W2013299392 @default.
- W2943890907 hasRelatedWork W2032191029 @default.
- W2943890907 hasRelatedWork W2063401993 @default.
- W2943890907 hasRelatedWork W2084062459 @default.
- W2943890907 hasRelatedWork W2096641431 @default.
- W2943890907 hasRelatedWork W2155596957 @default.
- W2943890907 hasRelatedWork W2393257291 @default.
- W2943890907 hasVolume "1120" @default.
- W2943890907 isParatext "false" @default.
- W2943890907 isRetracted "false" @default.
- W2943890907 magId "2943890907" @default.
- W2943890907 workType "article" @default.