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• W2943909007 abstract "Future Science Book SeriesMicrowaves in Drug Discovery and Development: Recent Advances Classical and microwave-assisted synthesis of cucurbit[n]urils, hemicucurbit[n]urils and bambus[n]urilsOliver B SutcliffeOliver B SutcliffeOliver Sutcliffe graduated from the University of Liverpool (UK) with a BSc (Hons) in chemical sciences (1996) and subsequently obtained a PhD in synthetic organic chemistry working on ‘New Extended Dipolar Systems’ under Richard C Storr and Thomas L Gilchrist from the same institution. In 1999, he joined Martin R Bryce’s group at the University of Durham (UK) as a postdoctoral fellow investigating the application of enantiopure ferrocene ligands in asymmetric synthesis, before moving to industry and working as a medicinal chemist on the design, development and optimization of drug molecules for a broad range of biological targets, including cancer. He moved to the University of Strathclyde (UK) in 2006, obtained an MSc in pharmaceutical analysis and, after a period at the European Directorate for the Quality of Medicines and Healthcare (EDQM) in Strasbourg (France), was appointed as a lecturer in the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS). In January 2012, he joined the staff at Manchester Metropolitan University (UK) as both a Senior Lecturer in Pharmaceutical and Analytical Chemistry and Co-Director of the Manchester Centre for the Study of Legal Highs (MCSLH). His research interests include the isolation, identification and analysis of ‘new psychoactive substances’ (formally known as ‘legal highs’), such as mephedrone and its derivatives, and the development of simple, rapid and selective presumptive tests and devices that can be applied by nonspecialists for the detection of illicit substances in the field. He is the coinventor of ten international patents and coauthor of 33 peer-reviewed research articles.Search for more papers by this authorPublished Online:30 Oct 2014https://doi.org/10.4155/fseb2013.13.88AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInRedditEmail View chapterAbstract: This chapter gives a concise overview of the synthetic and supramolecular chemistry of cucurbit[n]uril (CB[n]) family of macrocycles and expands it to hemicucurbit[n]urils (HemCB[n]) and bambus[n]urils (BU[n]). The application of microwave-assisted synthesis to access these macrocycles is reviewed. Several extensive papers describing the synthesis, physical and recognition properties and applications of CB[n]s have been published and the reader is directed to these key sources throughout this chapter. References1 Lagona J , Mukhopadhyay P , Chakrabarti S , Isaacs L . The cucurbit[n]uril family . Angew. Chem. Int. 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Cosmetic agents containing macrocycles selected from the group of cucurbituril and hemicucurbituril derivatives. DE102006011317 (2007) . Google ScholarFiguresReferencesRelatedDetails Microwaves in Drug Discovery and Development: Recent AdvancesMetrics Downloaded 7 times History Published online 30 October 2014 Published in print October 2014 Information© Future Science Ltd© Future Science LtdPDF download" @default.
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