FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943910802> ?p ?o ?g. }

• W2943910802 abstract "Background: The choice of empirical antibiotic treatment for patients with community-acquired pneumonia (CAP) who are admitted to non-intensive care unit (ICU) hospital wards is complicated by the limited availability of evidence. We systematically reviewed the efficacy and safety of strategies of empirical treatment with respiratory fluoroquinolone monotherapy and β-lactam with or without macrolide for non-ICU hospitalized CAP patients. Methods: We searched databases including PubMed, the Cochrane Library (Issue11, 2018), EMbase, China National Knowledge Internet (CNKI), WanFang Data, VIP, and China Biology Medicine disc (CBMdisc) to identify randomized controlled trials (RCTs) involving the comparison of respiratory fluoroquinolone monotherapy and β-lactam with or without macrolide for the non-ICU hospitalized patients with CAP up to November 2018. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias of the included studies. A meta-analysis was performed with the outcomes. Results: A total of 22 studies involving 6,235 patients were included. The results of the meta-analysis showed a non-significant trend toward an advantage to the respiratory fluoroquinolone in overall mortality (RR 0.82, 95% CI 0.65-1.02). No significant difference was found between the two strategies in clinical success (the intention-to-treat population: RR 1.03, 95% CI 0.99-1.08; the clinically evaluable population: RR 1.03, 95% CI 0.999-1.055; the population in which it was unclear whether intention-to-treat or per-protocol analysis was used: RR 1.04, 95% CI 0.99-1.09), microbiological treatment success (RR 1.04, 95% CI 0.997-1.092), and length of stay (SMD -0.06, 95% CI -0.16 to 0.04). The advantage of respiratory fluoroquinolone was statistically significant on the drug-related adverse events (RR 0.87, 95% CI 0.77-0.97). Conclusions: Current evidence shows that fluoroquinolone monotherapy has similar efficacy and favorable safety compared with β-lactam with or without macrolide for non-ICU hospitalized CAP patients. Since the limitation of region, quantity and quality of included studies, more RCTs with large scale and high quality are needed to verify the above conclusion." @default.
• W2943910802 created "2019-05-16" @default.
• W2943910802 creator A5004514234 @default.
• W2943910802 creator A5006698197 @default.
• W2943910802 creator A5013297039 @default.
• W2943910802 creator A5016520323 @default.
• W2943910802 creator A5035702164 @default.
• W2943910802 creator A5039095607 @default.
• W2943910802 creator A5046061491 @default.
• W2943910802 creator A5066716873 @default.
• W2943910802 creator A5080540482 @default.
• W2943910802 creator A5088569719 @default.
• W2943910802 date "2019-05-08" @default.
• W2943910802 modified "2023-09-22" @default.
• W2943910802 title "Respiratory Fluoroquinolones Monotherapy vs. β-Lactams With or Without Macrolides for Hospitalized Community-Acquired Pneumonia Patients: A Meta-Analysis" @default.
• W2943910802 cites W1564014304 @default.
• W2943910802 cites W1987635163 @default.
• W2943910802 cites W1988039140 @default.
• W2943910802 cites W2001682416 @default.
• W2943910802 cites W2004049422 @default.
• W2943910802 cites W2005332286 @default.
• W2943910802 cites W2031223726 @default.
• W2943910802 cites W2044455259 @default.
• W2943910802 cites W2048754396 @default.
• W2943910802 cites W2098920479 @default.
• W2943910802 cites W2099867105 @default.
• W2943910802 cites W2103633001 @default.
• W2943910802 cites W2112310123 @default.
• W2943910802 cites W2122273366 @default.
• W2943910802 cites W2133440505 @default.
• W2943910802 cites W2133979383 @default.
• W2943910802 cites W2134903735 @default.
• W2943910802 cites W2135688996 @default.
• W2943910802 cites W2140411972 @default.
• W2943910802 cites W2150772812 @default.
• W2943910802 cites W2155652215 @default.
• W2943910802 cites W2157001727 @default.
• W2943910802 cites W2166836716 @default.
• W2943910802 cites W2422709615 @default.
• W2943910802 cites W2741591398 @default.
• W2943910802 cites W2747793027 @default.
• W2943910802 cites W2793938485 @default.
• W2943910802 cites W3031894622 @default.
• W2943910802 cites W3145041166 @default.
• W2943910802 cites W4255457807 @default.
• W2943910802 cites W219020520 @default.
• W2943910802 doi "https://doi.org/10.3389/fphar.2019.00489" @default.
• W2943910802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6517694" @default.
• W2943910802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31139081" @default.
• W2943910802 hasPublicationYear "2019" @default.
• W2943910802 type Work @default.
• W2943910802 sameAs 2943910802 @default.
• W2943910802 citedByCount "7" @default.
• W2943910802 countsByYear W29439108022020 @default.
• W2943910802 countsByYear W29439108022021 @default.
• W2943910802 countsByYear W29439108022022 @default.
• W2943910802 countsByYear W29439108022023 @default.
• W2943910802 crossrefType "journal-article" @default.
• W2943910802 hasAuthorship W2943910802A5004514234 @default.
• W2943910802 hasAuthorship W2943910802A5006698197 @default.
• W2943910802 hasAuthorship W2943910802A5013297039 @default.
• W2943910802 hasAuthorship W2943910802A5016520323 @default.
• W2943910802 hasAuthorship W2943910802A5035702164 @default.
• W2943910802 hasAuthorship W2943910802A5039095607 @default.
• W2943910802 hasAuthorship W2943910802A5046061491 @default.
• W2943910802 hasAuthorship W2943910802A5066716873 @default.
• W2943910802 hasAuthorship W2943910802A5080540482 @default.
• W2943910802 hasAuthorship W2943910802A5088569719 @default.
• W2943910802 hasBestOaLocation W29439108021 @default.
• W2943910802 hasConcept C126322002 @default.
• W2943910802 hasConcept C142724271 @default.
• W2943910802 hasConcept C168563851 @default.
• W2943910802 hasConcept C177713679 @default.
• W2943910802 hasConcept C204787440 @default.
• W2943910802 hasConcept C2776102371 @default.
• W2943910802 hasConcept C2776376669 @default.
• W2943910802 hasConcept C2776478404 @default.
• W2943910802 hasConcept C2777596629 @default.
• W2943910802 hasConcept C2777914695 @default.
• W2943910802 hasConcept C2908647359 @default.
• W2943910802 hasConcept C44249647 @default.
• W2943910802 hasConcept C71924100 @default.
• W2943910802 hasConcept C82789193 @default.
• W2943910802 hasConcept C95190672 @default.
• W2943910802 hasConcept C99454951 @default.
• W2943910802 hasConceptScore W2943910802C126322002 @default.
• W2943910802 hasConceptScore W2943910802C142724271 @default.
• W2943910802 hasConceptScore W2943910802C168563851 @default.
• W2943910802 hasConceptScore W2943910802C177713679 @default.
• W2943910802 hasConceptScore W2943910802C204787440 @default.
• W2943910802 hasConceptScore W2943910802C2776102371 @default.
• W2943910802 hasConceptScore W2943910802C2776376669 @default.
• W2943910802 hasConceptScore W2943910802C2776478404 @default.
• W2943910802 hasConceptScore W2943910802C2777596629 @default.
• W2943910802 hasConceptScore W2943910802C2777914695 @default.
• W2943910802 hasConceptScore W2943910802C2908647359 @default.
• W2943910802 hasConceptScore W2943910802C44249647 @default.
• W2943910802 hasConceptScore W2943910802C71924100 @default.
• W2943910802 hasConceptScore W2943910802C82789193 @default.
• W2943910802 hasConceptScore W2943910802C95190672 @default.

• next