Matches in SemOpenAlex for { <https://semopenalex.org/work/W2943931148> ?p ?o ?g. }
- W2943931148 endingPage "201" @default.
- W2943931148 startingPage "189" @default.
- W2943931148 abstract "Abstract This MiniReview reports the current knowledge about the treatment of arterial hypertension with the third‐generation beta‐adrenoceptor antagonist (BAA) nebivolol. Furthermore, it reviews the advantages of nebivolol compared to the earlier generation of BAAs with respect to their different pharmacological properties. Beta‐adrenoceptor antagonists are a class of drugs applied for several different conditions, including hypertension and heart failure. They differ significantly in their pharmacological properties, including varying β 1 /β 2 ‐selectivity and/or exertion of additive effects on the heart and circulation. Although these drugs have been a part of hypertensive therapy for about 40 years, the outcome of large clinical trials has put the role of BAAs into question. However, most of these results were based on first‐ and second‐generation BAAs and cannot be translated directly into third‐generation drugs. The third‐generation BAA nebivolol has the highest β 1 ‐selectivity seen so far, together with additional vasodilating and anti‐oxidative properties. It is currently applied in the treatment of hypertension and congestive heart failure. Nebivolol has a unique pharmacological profile, despite showing similar blood pressure‐lowering effects, and has certain advantages in the treatment of hypertension compared to the previous generations of BAAs. This includes significant improvements in endothelial dysfunction, central haemodynamics and the degree of erectile dysfunction in men, a neutral/beneficial metabolic profile and lastly a more favourable side effect profile. It is widely beneficial for, for example, sexually active men and patients with comorbidities such as type II diabetes mellitus, metabolic syndrome and chronic obstructive lung disorders. Whether the advantages translate to an improved long‐term clinical outcome remains to be clarified, and ongoing prospective studies will show this in the future." @default.
- W2943931148 created "2019-05-16" @default.
- W2943931148 creator A5015354144 @default.
- W2943931148 creator A5017701621 @default.
- W2943931148 creator A5081634976 @default.
- W2943931148 creator A5082120013 @default.
- W2943931148 creator A5086317763 @default.
- W2943931148 date "2019-07-04" @default.
- W2943931148 modified "2023-10-03" @default.
- W2943931148 title "Nebivolol in the treatment of arterial hypertension" @default.
- W2943931148 cites W1494527914 @default.
- W2943931148 cites W1521358982 @default.
- W2943931148 cites W15274272 @default.
- W2943931148 cites W1654546921 @default.
- W2943931148 cites W1965711400 @default.
- W2943931148 cites W1967788840 @default.
- W2943931148 cites W1969381360 @default.
- W2943931148 cites W1977607782 @default.
- W2943931148 cites W1978190600 @default.
- W2943931148 cites W1978372333 @default.
- W2943931148 cites W1978626459 @default.
- W2943931148 cites W1983500350 @default.
- W2943931148 cites W1984366579 @default.
- W2943931148 cites W1985425264 @default.
- W2943931148 cites W1997017989 @default.
- W2943931148 cites W2002982077 @default.
- W2943931148 cites W2014594848 @default.
- W2943931148 cites W2014680498 @default.
- W2943931148 cites W2015369316 @default.
- W2943931148 cites W2024263079 @default.
- W2943931148 cites W2025202792 @default.
- W2943931148 cites W2025376453 @default.
- W2943931148 cites W2027171416 @default.
- W2943931148 cites W2032474996 @default.
- W2943931148 cites W2033234352 @default.
- W2943931148 cites W2036336318 @default.
- W2943931148 cites W2041009838 @default.
- W2943931148 cites W2050456004 @default.
- W2943931148 cites W2057106451 @default.
- W2943931148 cites W2058950521 @default.
- W2943931148 cites W2064022594 @default.
- W2943931148 cites W2065193829 @default.
- W2943931148 cites W2065593854 @default.
- W2943931148 cites W2065726373 @default.
- W2943931148 cites W2066944950 @default.
- W2943931148 cites W2069007462 @default.
- W2943931148 cites W2081408855 @default.
- W2943931148 cites W2085380381 @default.
- W2943931148 cites W2086795013 @default.
- W2943931148 cites W2087839793 @default.
- W2943931148 cites W2091587299 @default.
- W2943931148 cites W2097570455 @default.
- W2943931148 cites W2100249758 @default.
- W2943931148 cites W2105944519 @default.
- W2943931148 cites W2114333967 @default.
- W2943931148 cites W2114369401 @default.
- W2943931148 cites W2121185174 @default.
- W2943931148 cites W2122468991 @default.
- W2943931148 cites W2123651599 @default.
- W2943931148 cites W2129991662 @default.
- W2943931148 cites W2133217116 @default.
- W2943931148 cites W2135491838 @default.
- W2943931148 cites W2138354938 @default.
- W2943931148 cites W2152660527 @default.
- W2943931148 cites W2159854507 @default.
- W2943931148 cites W2162358892 @default.
- W2943931148 cites W2163398369 @default.
- W2943931148 cites W2167760816 @default.
- W2943931148 cites W2169054045 @default.
- W2943931148 cites W2181241483 @default.
- W2943931148 cites W2197190691 @default.
- W2943931148 cites W2201917454 @default.
- W2943931148 cites W2305951000 @default.
- W2943931148 cites W2329490823 @default.
- W2943931148 cites W2334342045 @default.
- W2943931148 cites W2338613123 @default.
- W2943931148 cites W2343313313 @default.
- W2943931148 cites W2385482476 @default.
- W2943931148 cites W2538472873 @default.
- W2943931148 cites W2539864244 @default.
- W2943931148 cites W2550433123 @default.
- W2943931148 cites W2560146075 @default.
- W2943931148 cites W2571435884 @default.
- W2943931148 cites W2593451622 @default.
- W2943931148 cites W2594306880 @default.
- W2943931148 cites W2595587954 @default.
- W2943931148 cites W2604507057 @default.
- W2943931148 cites W2614506045 @default.
- W2943931148 cites W2735497612 @default.
- W2943931148 cites W2767391531 @default.
- W2943931148 cites W2768354106 @default.
- W2943931148 cites W2796573899 @default.
- W2943931148 cites W2888589263 @default.
- W2943931148 cites W2891483171 @default.
- W2943931148 cites W3015044731 @default.
- W2943931148 cites W44463084 @default.
- W2943931148 cites W910021339 @default.
- W2943931148 doi "https://doi.org/10.1111/bcpt.13248" @default.